Smilowitz, Henry - University of Connecticut

研究领域

a. Use of gold nanoparticles for tumor imaging, vascular imaging and as a radiation enhancer for tumor therapy. b. Use of iron and gold nanoparticles for tumor hyperthermia c. Development of novel brain tumor therapies for experimental, advanced, imminently lethal intracerebral malignant gliomas and melanomas in rats and mice using a combination of radiation therapy and immunotherapy. d. Novel biomarkers in human breast cancer.

近期论文

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Hainfeld, J.F., Lin L, Slatkin D.N., Dilmanian F.A., Smilowitz H.M. 2014. Gold nanoparticle hyperthermia reduces radiation dose. Nanomedicine: Nanotechnology, Biology and Medicine. 10:1609-1617. Hainfeld, J.F., O’Connor, M.J., Lin, P., Qian, L., Slatkin, D.N. Smilowitz, H.M. 2014. Infrared-transparent gold nanoparticles converted by tumors to infrared absorbers cure tumors in mice by photothermal therapy. PLoS 9:e88414. Hainfeld, J.F., Smilowitz, H.M., O’Connor, M.J., Dilmanian, F.A., Slatkin, D.N. 2012. Gold nanoparticle imaging and radiotherapy of brain tumors in mice. Nanomedicine London (Future Medicine).8:1601-1609. pdf Hainfeld, J.F., O’Connor, M.J., Dilmanian, F.A., Slatkin, D.N., Adams, D.J., Smilowitz, H.M. 2011. MicroCT enables microlocalization and quantification of Her-2-targeted gold nanoparticles within tumor regions. British Journal of Radiology, 84:526-533.(PMID 21081567). Hainfeld, J.F., O’Connor, M.J., Lin, P.P., Smilowitz, H.M. 2010 Cancer therapy with wIRA and gold nanoparticles in water-filtered and infrared-A radiation: From Basic Principles to Clinical Applications. Hainfeld, J.F., Dilmanian, F.A., Zhong Z., Slatkin, D.N., Smilowitz, H.M. 2010 Gold nanoparticles enhance radiation therapy of a squamous cell carcinoma growing in mice. Physics in Medicine and Biology, 55: 3045-3059 (PMID 20463371). pdf Hainfeld, J.F., Slatkin, D.N., Dilmanian, F.A., Smilowitz, H.M. 2008. Radiotherapy enhancement with gold nanoparticles. J. Pharmacy and Pharmacology, 60: 977-985 (PMID 18644191) Volume 60 #8 is a Special Issue: Radiation Biology – Can New Concepts Achieve Better Treatment Outcomes? JPP has informed us that this paper is one of the top 25 most downloaded papers in 2008, >100X through 12/08. pdf Hainfeld, J.F., Slatkin, D.N., Focella, T., Smilowitz, H. 2006. Gold nanoparticles as X Ray contrast agents. British Journal of Radiology. 79: 248-253 (PMID 16498039). pdf Hainfeld, J.F., Slatkin, D. N., Smilowitz, H.M. 2004. The use of gold nanoparticles to enhance radiotherapy in mice. Physics in Medicine and Biology, 49: N309 (PMID 15509078). Note: This paper has been selected for inclusion in Institute of Physics (IOP) Select, Institute of Physics, London, England. pdf Novel Biomarkers in human breast cancer. Blood samples from women with breast cancer are being screened for the presence of novel biomarkers that may be linked to more aggressive disease.