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B.S. University of Notre Dame Microbiology M.S. University of Michigan Microbiology and Immunology Ph.D. University of Michigan Microbiology and Immunology

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PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer.Caromile, Leslie Ann; Dortche, Kristina; Rahman, M Mamunur; Grant, Christina L; Stoddard, Christopher; Ferrer, Fernando A; Shapiro, Linda H Science signaling 2017 Mar;10(470): Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide.Conway, Rebecca E; Rojas, Camilo; Alt, Jesse; Nováková, Zora; Richardson, Spencer M; Rodrick, Tori C; Fuentes, Julio L; Richardson, Noah H; Attalla, Jonathan; Stewart, Samantha; Fahmy, Beshoy; Barinka, Cyril; Ghosh, Mallika; Shapiro, Linda H; Slusher, Barbara S Angiogenesis 2016 Jul; Proximal tubule proteins are significantly elevated in bladder urine of patients with ureteropelvic junction obstruction and may represent novel biomarkers: A pilot study.Gerber, Claire; Harel, Miriam; Lynch, Miranda L; Herbst, Katherine W; Ferrer, Fernando A; Shapiro, Linda H Journal of pediatric urology 2016 Apr;12(2):120.e1-7 Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma.Li, Mei-Hong; Swenson, Rolf; Harel, Miriam; Jana, Sampa; Stolarzewicz, Erik; Hla, Timothy; Shapiro, Linda H; Ferrer, Fernando The Journal of pharmacology and experimental therapeutics 2015 Jun;354(3):261-8 CD13 restricts TLR4 endocytic signal transduction in inflammation.Ghosh, Mallika; Subramani, Jaganathan; Rahman, M Mamunur; Shapiro, Linda H Journal of immunology (Baltimore, Md. : 1950) 2015 Mar;194(9):4466-76 The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease.Kim, Jiyeon; Shapiro, Linda; Flynn, Aidan Pharmacology & therapeutics 2015 Feb;1518-15 Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction.Thangada, Shobha; Shapiro, Linda H; Silva, Cynthia; Yamase, Harold; Hla, Timothy; Ferrer, Fernando A The Journal of urology 2014 Mar;191(5 Suppl):1508-16 Molecular mechanisms regulating CD13-mediated adhesion.Ghosh, Mallika; Gerber, Claire; Rahman, M Mamunur; Vernier, Kaitlyn M; Pereira, Flavia E; Subramani, Jaganathan; Caromile, Leslie A; Shapiro, Linda H Immunology 2014 Mar;142(4):636-47 CD13 promotes mesenchymal stem cell-mediated regeneration of ischemic muscle.Rahman, M Mamunur; Subramani, Jaganathan; Ghosh, Mallika; Denninger, Jiyeon K; Takeda, Kotaro; Fong, Guo-Hua; Carlson, Morgan E; Shapiro, Linda H Frontiers in physiology 2014 Jan;4402 CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury.Rahman, M Mamunur; Ghosh, Mallika; Subramani, Jaganathan; Fong, Guo-Hua; Carlson, Morgan E; Shapiro, Linda H Stem cells (Dayton, Ohio) 2013 Dec;32(6):1564-77 CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice.Pereira, Flavia E; Cronin, Chunxia; Ghosh, Mallika; Zhou, Si-Yuan; Agosto, Mariela; Subramani, Jaganathan; Wang, Ruibo; Shen, Jian-Bing; Schacke, Wolfgang; Liang, Brannen; Yang, Tie Hong; McAulliffe, Beata; Liang, Bruce T; Shapiro, Linda H Cardiovascular research 2013 Oct;100(1):74-83 Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking.Subramani, Jaganathan; Ghosh, Mallika; Rahman, M Mamunur; Caromile, Leslie A; Gerber, Claire; Rezaul, Karim; Han, David K; Shapiro, Linda H Journal of immunology (Baltimore, Md. : 1950) 2013 Aug;191(7):3905-12 Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2.Conway, Rebecca E; Joiner, Kyle; Patterson, Alex; Bourgeois, David; Rampp, Robert; Hannah, Benjamin C; McReynolds, Samantha; Elder, John M; Gilfilen, Hannah; Shapiro, Linda H Angiogenesis 2013 Jun;16(4):847-60 Prostate specific membrane antigen (PSMA) regulates angiogenesis independently of VEGF during ocular neovascularization.Grant, Christina L; Caromile, Leslie A; Ho, Vivienne; Durrani, Khayyam; Rahman, M Mamunur; Claffey, Kevin P; Fong, Guo-Hua; Shapiro, Linda H PloS one 2012 Jul;7(7):e41285 CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake.Ghosh, Mallika; McAuliffe, Beata; Subramani, Jaganathan; Basu, Sreyashi; Shapiro, Linda H Journal of immunology (Baltimore, Md. : 1950) 2012 Jun;188(11):5489-99 CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse.Winnicka, Beata; O'Conor, Catherine; Schacke, Wolfgang; Vernier, Kaitlyn; Grant, Christina L; Fenteany, Fiona Hall; Pereira, Flavia E; Liang, Brannen; Kaur, Anupinder; Zhao, Ran; Montrose, David C; Rosenberg, Daniel W; Aguila, Hector L; Shapiro, Linda H Journal of leukocyte biology 2010 Aug;88(2):347-59 Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Group's Study, ASCT0031Cuvelier G.D.E., Kariminia A., Fujii H., Aslanian S., Wall D., Goldman F., Grupp S.A., Dunn S.E., Krailo M., Shapiro L.H., Gilman A., Schultz K.R. Bone Marrow Transplantation 2010 Jan; CD13 is a novel mediator of monocytic/endothelial cell adhesion.Mina-Osorio, Paola; Winnicka, Beata; O'Conor, Catherine; Grant, Christina L; Vogel, Lotte K; Rodriguez-Pinto, Daniel; Holmes, Kathryn V; Ortega, Enrique; Shapiro, Linda H Journal of leukocyte biology 2008 Aug;84(2):448-59 CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element.Mahoney, Kathleen M M; Petrovic, Nenad; Schacke, Wolfgang; Shapiro, Linda H Gene 2007 Nov;403(1-2):178-87 CD13/APN regulates endothelial invasion and filopodia formation.Petrovic, Nenad; Schacke, Wolfgang; Gahagan, J Reed; O'Conor, Catherine A; Winnicka, Beata; Conway, Rebecca E; Mina-Osorio, Paola; Shapiro, Linda H Blood 2007 Jul;110(1):142-50 Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction.Conway, Rebecca E; Petrovic, Nenad; Li, Zhong; Heston, Warren; Wu, Dianqing; Shapiro, Linda H Molecular and cellular biology 2006 Jul;26(14):5310-24 CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells.Fontijn, D; Duyndam, M C A; van Berkel, M P A; Yuana, Y; Shapiro, L H; Pinedo, H M; Broxterman, H J; Boven, E British journal of cancer 2006 Jun;94(11):1627-36 CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells.Mina-Osorio, Paola; Shapiro, Linda H; Ortega, Enrique Journal of leukocyte biology 2006 Apr;79(4):719-30 Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo.Wentworth, David E; Tresnan, D B; Turner, B C; Lerman, I R; Bullis, B; Hemmila, E M; Levis, R; Shapiro, L H; Holmes, Kathryn V Virology 2005 May;335(2):185-97 CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells.Petrovic, Nenad; Bhagwat, Shripad V; Ratzan, William J; Ostrowski, Michael C; Shapiro, Linda H The Journal of biological chemistry 2003 Dec;278(49):49358-68

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