Rodriguez-Oquendo, Annabelle - University of Connecticut

研究领域

The Rodriguez-Oquendo lab is studying the genetic link between healthy HDL cholesterol, heart disease, and infertility in women. This work suggests that variations within the SCARB1 gene, connected to HDL levels, are associated with heart disease risk as well as hormonal and fertility problems in women. The goal of the research discoveries is the development of methods to diagnose and, ultimately, treat heart disease and improve a woman’s ability to conceive

近期论文

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Diana Golden, Antonina Kolmakova,Sunitha Sura,Anthony T. Vella, Ani Manichaikul, Xin-Qun Wang, Suzette J. Bielinski,Kent D. Taylor, Yii-Der Ida Chen, Stephen S. Rich, and Annabelle Rodriguez. Lymphocyte activation gene 3 and coronary artery disease. JCI Insight. 2016;1(17):e88628. doi:10.1172/jci.insight.88628. pdf Ménoret A, Crocker SJ, Rodriguez A, Rathinam VA, Clark RB, Vella AT. Transition from identity to bioactivity-guided proteomics for biomarker discovery with focus on the PF2D platform. Proteomics Clin Appl. 2016 Jan;10(1):8-24. doi: 10.1002/prca.201500029. Epub 2015 Sep 16. Review. pdf Cameron SJ, Morrell CN, Bao C, Swaim AF, Rodriguez A, Lowenstein CJ. A Novel Anti-Inflammatory Effect for High Density Lipoprotein. PLoS One. 2015 Dec 17;10(12):e0144372. doi: 10.1371/journal.pone.0144372. eCollection 2015. pdf Everett BM, Brooks MM, Vlachos HE, Chaitman BR, Frye RL, Bhatt DL; BARI 2D Study Group. Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes. N Engl J Med. 2015 Aug 13;373(7):610-20. doi: 10.1056/NEJMoa1415921. pdf Manichaikul A, Wang XQ, Musani SK, Herrington DM, Post WS, Wilson JG, Rich SS, Rodriguez A. Association of the Lipoprotein Receptor SCARB1 Common Missense Variant rs4238001 with Incident Coronary Heart Disease. PLoS One. 2015 May 20;10(5):e0125497. doi: 10.1371/journal.pone.0125497. eCollection 2015. pdf Vickers KC, Rodriguez A. Human scavenger receptor class B type I variants, lipid traits, and cardiovascular disease. Circ Cardiovasc Genet. 2014 Dec;7(6):735-7. doi: 10.1161/CIRCGENETICS.114.000929. No abstract available. pdf DeAngelis AM, Roy-O'Reilly M, Rodriguez A. Genetic alterations affecting cholesterol metabolism and human fertility. Biol Reprod. 2014 Nov;91(5):117. doi: 10.1095/biolreprod.114.119883. Epub 2014 Aug 13. Review. pdf Rodriguez A, Magee M, Ramos P, Seley JJ, Nolan A, Kulasa K, Caudell KA, Lamb A, MacIndoe J, Maynard G. Best Practices for Interdisciplinary Care Management by Hospital Glycemic Teams: Results of a Society of Hospital Medicine Survey Among 19 U.S. Hospitals. Diabetes Spectr. 2014 Aug;27(3):197-206. doi: 10.2337/diaspect.27.3.197. pdf Manichaikul, A., Naj, A.C., Herrington, D., Post, W., Rich, S.S., Rodriguez, A., 2012. Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: The Multi-Ethnic Study of Artherosclerosis. Arterioscl Throm Vas 32: pp. 1991-1999. pdf Yates, M., Kolmakova, A., Zhao, Y., Rodriguez, A. 2011. Clinical impact of scavenger class B type I gene polymorphisms on human female fertility, Hum Reprod 26: pp. 1910-1916. pdf Rodriguez, A., Canto, M.I., Makary, M.A., 2011. Endoscopic localization and tattooing of a proinsulinoma for minimally invasive resection. Pancreas 40: pp. 474-477. pdf Zhao, Y., Garcia, J., Kolp, L., Cheadle, C., Rodriguez, A., Vlahos, N.F., 2010. The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Fertil Steril 94: pp. 2264-2271. pdf Kolmakova, A., Wang, J., Brogan, R., Chaffin, C., Rodriguez, A. 2010. Deficiency of scavenger receptor class B type I receptor negatively affects progesterone secretion in human granulosa cells. Endocrinology 151: pp. 5519-5527. pdf Naj, A.C., West, M., Rich, S.S., Post, W., Kao, W.H.L., Herrington, D.M., Wasserman, B., Rodriguez, A. 2010. Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: Multi-Ethnic Study of Atheroschlerosis. Circ Cardiovasc Genet 3: pp. 47-52. pdf Constantineau, J., Greason, E., West, M., Filbin, M., Kieft, J.S., Carletti, M.Z., Christenson, L.K., Rodriguez, A. 2010. The synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression an function. Artherosclerosis 210: pp. 177-182. pdf Pambianco, G., Lombardero, M., Bittner, V., Forker, A., Kennedy, F., Krishnaswami, A., Mooradian, A.D., Pop-Busui, R., Rana, J.S., Rodriguez, A., Steffes, M., Orchard, T.J. 2009. Control of lipids at baseline in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARD 2D) Trial. Prev Cardiol 12: pp. 9-18. pdf Cherian-Shaw, M., Puttabyatappa, M., Greason, E., Rodriguez, A., Vandevoort, C.A.,Chaffin, C.L. 2009. Expression of scavenger receptor-BI and low density lipoprotein receptor and differential use of lipoproteins to support early steroidogenesis in luteinizing macaque granulosa cells. Endocrinology 150: pp. 957-965. pdf West, M., Greason, E., Kolmakova, A., Jahangiri, A., Asztalos, B., Pollin, T.I., Rodriguez, A., 2009. Scavenger receptor class B type I protein as an independent predictor of high density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia. J Clin Endocrinol Metab 94: pp. 1451-1457. pdf Roberts, C.G.P., Rodriguez, A. 2008. Authors' response to letter from strandberg and colleagues. J Gerontol A Bio Sci Med Sci. Lipari, C.W., Garcia, J.E., Zhao, Y., Thrift, K., Vaidya, D., Rodriguez, A. 2008. Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation. Fertil Steril 28: pp. 1316-1318. pdf Rodriguez, A., Muller, D.C., Metter, J., Harman, S.M., Blackman, M.R., Andres, R. 2007. Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab 92: pp. 3568-3572. pdf Savransky, V., Nanayakkara, A., Li, J., Bevans, S., Smith, P.L., Rodriguez, A., Polotsky, V.Y. 2007. Chronic intermittent hypoxia induces atherosclerosis. American Journal of Respiutory and Critical Care Medicine 175: pp.1290-1297. pdf Roberts, C.G.P., Shen, H., Mitchell, B.D., Damcott, C.M., Shuldiner, A., Rodriguez, A., 2007. Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women. Hum Hered 64: pp. 107-113. pdf Roberts, C.G.P., Gualler, E., Rodriguez, A. 2007. Efficacy and safety of statin monotherapy on clinical outcomes in older adults: a meta-analysis. J Gerontology A Biol Sci Med 64: pp.107-113. pdf Derr, R., Sivanandy, M., Bronich-Hall, Rodriguez, A. 2007. Insulin-related knowledge among health care professionals in internal medicine. Diabetes Spectrum 20: pp.879-887. pdf