个人简介

B.S. (2003) University of Notre Dame Ph.D. (2008) University of Pennsylvania NIH Postdoctoral Fellow (2008-2011), Harvard Medical School

研究领域

Biological Chemistry; Organic Chemistry

The Wuest group is an interdisciplinary team of researchers that leverages techniques in synthetic organic chemistry, biochemistry, and microbiology to better understand the chemical biology of bacterial biofilms. Biofilms are self-produced matrices of extracellular polymeric substances, which include extracellular DNA, proteins, sugars, and lipids that serve as the first line of defense for bacteria. They are ubiquitous in nature, burdening both industry (biofouling/biocorrosion) and society (antibiotic resistance, indwelling devices). Taking inspiration from Nature, we have identified a variety of structures that specifically perturb unique processes in biofilm development. More excitingly, some of these motifs posses species-specific activity opening the door for the development of “narrow-spectrum” therapies, an emerging area of research spurred on by the human microbiome project. Our group is well positioned to explore this growing field and will continue to discover exciting new incites concerning the chemical biology of biofilms.

近期论文

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Wakefield, A.E.; Wuest, W.M.; Voelz, V.A. “Molecular Simulation of Conformational Pre-organization in Cyclic RGD Peptides.” J. Chem. Inf. Model, 2015, ASAP. DOI: 10.1021/ci500768u Paniak, T.J.; Jennings, M.C.; Shanahan, P.C.; Joyce, M.D.; Santiago, C.N.; Wuest, W.M.*; Minbiole, K.P.C.* “The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms.” Bioorg. Med. Chem. Lett. 2014, 24, 5824. DOI: 10.1016/j.bmcl.2014.10.018 Kinzie, C.R.; Steele, A.D.; Pasciolla, S.M.; Wuest, W.M.* “Synthesis of cyclic dimeric methyl morpholinoside – a common synthetic precursor to cyclic dinucleotide analogs.” Tet. Lett. 2014, 55, 4966. DOI: 10.1016/j.tetlet.2014.07.038 Ator, L.C.; Jennings, M.C.; McGettigan, A.R.; Paul, J.J.; Wuest, W.M.*; Minbiole, K.P.C.* “Beyond paraquats: Dialkyl 3,3′- and 3,4′-bipyridinium amphiphiles as antibacterial agents” Bioorg. Med. Chem. Lett. 2014, 24, 3706. DOI: 10.1016/j.bmcl.2014.07.024 Jennings, M.C.; Ator, L.C.; Paniak, T.J.; Minbiole, K.P.C.*; Wuest, W.M.* “Biofilm Eradicating Properties of Quaternary Ammonium Amphiphiles: Simple Mimics of Antimicrobial Peptides” ChemBioChem 2014, 15, 2211. DOI: 10.1002/cbic.201402254 Fletcher, M.H.; Jennings, M.C.; Wuest, W.M.* “Draining the moat: Disrupting bacterial biofilms with natural products” Tetrahedron 2014, 70, 6373. DOI: 10.1016/j.tet.2014.06.055 (invited review) Wuest, W.M.*; Wuest, L.M* “Using Technology to Create an Active, Collaborative Learning Environment: Even in Organic Chemistry!” Proceedings of the 2014 Lilly Conference on College and University Teaching and Learning 2014, 44. Razavi, A. M.; Wuest, W.M.*; Voelz, V.A.* “Computational screening and selection of cyclic peptide hairpin mimetics by molecular simulation and kinetic network models.” J. Chem. Inf. Model. 2014, 54, 1425. DOI: 10.1021/ci500102y Hallside, M.S.; Brzozowski, R.S.; Wuest, W.M.*; Phillips, A.J.* “A Concise Synthesis of Carolacton” Org. Lett. 2014, 16, 1148. DOI: 10.1021/ol500004k Black, J.W.; Jennings, M.C.; Azarewicz, J.; Grenier, M.C.; Wuest, W.M.*; Minbiole, K.P.C.* “TMEDA-derived biscationic amphiphiles: An economical preparation of potent antibacterial agents” Bioorg. Med. Chem Lett. 2014, 24, 99. DOI: 10.1016/j.bmcl.2013.11.070 Wuest, W.M.; Krahn, D.; Kaiser, M.; Walsh, C.T.*; “Enzymatic Timing and Tailoring of Macrolactomization in Syringolin Biosynthesis.” Org. Lett. 2011, 13, 4518. DOI:10.1021/ol2016687 Imker, H.J.; Walsh, C.T.*; Wuest, W.M. “SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A.” J. Am. Chem. Soc. 2009, 131, 18263. DOI: 10.1021/ja909170u Wuest, W.M.; Sattely, E.S.; Walsh, C.T.* “Three Siderophores from One Bacterial Enzymatic Assembly Line.” J. Am. Chem. Soc. 2009, 131, 5056. DOI: 10.1021/ja900815w Smith III, A.B.*; Wuest, W.M. “Evolution of Multi-Component Anion Relay Chemistry (ARC): Construction of Architecturally Complex Natural and Unnatural Products.” Chem. Commun. 2008, 45, 5883. DOI: 10.1039/B810394A Smith III, A.B.*; Cox, J.M.; Furuichi, N.; Kenesky, C.S.; Zheng, J.; Atasoylu, O.; Wuest, W.M.; “Total Synthesis of (-)-2-epi-peloruside A.” Org. Lett. 2008, 10, 5501. DOI: 10.1021/ol8019132 Smith III, A.B.*; Kim, W.S.; Wuest, W.M.; “Ortho-TMS Benzaldehyde: an Effective Linchpin for Type II Anion Relay Chemistry (ARC).” Angew. Chem. Int. Ed. 2008, 47, 7082. DOI:10.1002/anie.200802301 Carney, J.M.; Donoghue, P.J.; Wuest, W.M.; Wiest, O.*; Helquist, P.* “Intramolecular Hydroamination of Aminoalkynes with Silver Phenanthroline Catalysts.” Org. Lett. 2008, 10, 3903. DOI: 10.1021/ol801458g