Mehlmann, Lisa - University of Connecticut - Department of Cell Biology

研究领域

My lab is interested in the regulation of meiosis in mammalian oocytes, as well as the cytoplasmic events that occur during the time an oocyte transitions from an immature cell to a mature egg capable of fertilization.

近期论文

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Bernhardt ,M.L., Lowther, K.M., Padilla-Banks, E., McDonough, C.E., Lee, K.N., Evsikov, A.V., Uliasz, T.F., Chidiac, P., Williams, C.J., and Mehlmann, L.M. 2015 Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs. Development 2015 142: 2633-2640. pdf Lowther, K.M. and Mehlmann, L.M. 2015. Embryonic Poly(A) Binding Protein (EPAB) is required during early stages of mouse oocyte development for chromatin organization, transcriptional silencing, and meiotic competence. BOR Papers in Press. Published on July 1, 2015 as DOI:10.1095/biolreprod.115.131359. pdf Mehlmann, L.M. 2013. Signalling for meiotic resumption in granulosa cells, cumulus cells, and oocyte. In: Mammalian Oogenesis, Coticchio, De Santis, and Albertini, eds. Springer Publishing Company, New York, NY, pp. 171-182. Lowther, K.M., Uliasz, T.F., Gotz, K.R., Nikolaev, V.O., and Mehlmann, L.M. 2013. Regulation of constitutive GPR3 signaling and surface localization by GRK2 and b-arrestin-2 overexpression in HEK293 cells. PLoS One 8: e65365. pdf Mehlmann, L.M. 2013. Losing mom's message: requirement for DCP1A and DCP2 in the degradation of maternal transcripts during oocyte maturation. Biol Reprod. 88: 1-2. pdf Guzeloglu-Kayisli, O., Lalioti, M.D., Aydiner, F., Sasson, I., Ilbay, O., Sakkas, D., Lowther, K.M., Mehlmann, L.M, and Seli, E. 2012. Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochem J. 446:47-58. pdf Lowther, K.M., Nikolaev, V.O., and Mehlmann, L.M. 2011. Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest. Reproduction 141:737-747. pdf Mann, J.S., Lowther, K.M., and Mehlmann, L.M. 2010. Reorganization of the endoplasmic reticulum and development of Ca2+ release mechanisms during meiotic maturation of human oocytes. Biol. Reprod. 83:578–583. pdf Lowther, K.M., Weitzman, V.N., Maier, D., and Mehlmann, L.M. 2009. Maturation, fertilization, and the structure and function of the endoplasmic reticulum in cryopreserved mouse oocytes. Biol. Reprod. 81:147-154. pdf Norris, R.P., Ratzan, W.J., Freudzon, M., Mehlmann, L.M., Krall, J., Movsesian, M.A., Wang, H., Ke, H., Nikolaev, V.O., and Jaffe, L.A. 2009. Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development 136:1869-1878. pdf DiLuigi, A., Weitzman, V.N., Pace, M.C., Siano, L.J., Maier, D., and Mehlmann, L.M. 2008. Meiotic arrest in human oocytes is maintained by a Gs signaling pathway. Biol. Reprod. 78:667-672. pdf Vaccari, S., Horner, K., Mehlmann, L.M., and Conti, M. 2008. Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest. Dev. Biol. 316:124-134. pdf Norris, R.P., Freudzon, M., Mehlmann, L.M., Cowan, A.E., Simon, A.M., Paul, D.L., Lampe, P.D., and Jaffe, L.A. 2008. Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption. Development 135:3229-3238.pdf Norris, R.P., Freudzon, L., Freudzon, M., Hand, A.R., Mehlmann, L.M., and Jaffe, L.A. 2007. A Gs-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-Gs signaling. Dev. Biol. 310:240-249. pdf Mehlmann, L.M., Kalinowski, R.R., Ross, L.F., Parlow, A.F., Hewlett, E.L. and Jaffe, L.A. 2006. Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte. Dev. Biol. 299:345-355. pdf Mehlmann, L.M. 2005. Stops and Starts in Mammalian Oocytes: Recent Advances in Understanding the Regulation of Meiotic Arrest and Oocyte Maturation. Reproduction 130:791-798. pdf Freudzon, L., Norris, R.P., Hand, A.R., Tanaka, S., Saeki, Y., Jones, T.L.Z., Rasenick, M.M., Berlot, C.H., Mehlmann, L.M., and Jaffe, L.A. 2005. Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein. J. Cell Biol. 171:255-265. pdf Mehlmann, L.M. 2005. Oocyte-specific expression of GPR3 is required for the maintenance of meiotic arrest in mouse oocytes. Dev. Biol. 288:397-404. pdf Mehlmann, L.M., and Jaffe, L.A. 2005. SH2 domain-mediated activation of a SRC family kinase is not required to initiate Ca2+ release at fertilization in mouse eggs. Reproduction: 129: 557-564. pdf Mehlmann, L.M., Saeki, Y., Tanaka, S., Brennan, T.J., Evsikov, A.V. Pendola, F.L., Knowles, B.B., Eppig, J.J., and Jaffe, L.A. 2004. The G s -linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science: 306: 1947 - 1950. pdf Kalinowski, R.R., Berlot, C.H., Jones, T.L.Z., Ross, L.F., Jaffe, L.A., and Mehlmann, L.M. 2004. Maintenance of meiotic prophase arrest in vertebrate oocytes by a G s protein-mediated pathway. Dev. Biol. 267: 1-13. pdf Mehlmann, L.M., Jones, T.L.Z., and Jaffe, L.A. 2002. Meiotic arrest in the mouse follicle maintained by a G s protein in the oocyte. Science 297:1343-1345. pdf Runft, L.L., Jaffe, L.A., and Mehlmann, L.M. 2002. Egg activation at fertilization: Where it all begins. Dev. Biol. 245:237-254. pdf