Laubenbacher, Reinhard - University of Connecticut

个人简介

Dr. Laubenbacher joined the University of Connecticut Health Center in May 2013 as Professor in the Department of Cell Biology and Co-Director of the Center for Quantitative Medicine. Prior to this appointment, he served as a Professor at the Virginia Bioinformatics Institute and a Professor in the Department of Mathematics at Virginia Tech since 2001. He was also an Adjunct Professor in the Department of Cancer Biology at Wake Forest University in Winston-Salem (NC) and Affiliate Faculty in the Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences. In addition, Dr. Laubenbacher was also Professor of Mathematics at New Mexico State University. He has served as Visiting Faculty at Los Alamos National Laboratories, was a member of the Mathematical Science Research Institute at Berkeley in 1998, and was a Visiting Associate Professor at Cornell University in 1990 and 1993. Current interests in Dr. Laubenbacher’s research group include the development of mathematical algorithms and their application to problems in systems biology, in particular the modeling and simulation of molecular networks. An application area of particular interest is cancer systems biology, especially the role of iron metabolism in breast cancer.

近期论文

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Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective.Chifman, Julia; Arat, Seda; Deng, Zhiyong; Lemler, Erica; Pino, James C; Harris, Leonard A; Kochen, Michael A; Lopez, Carlos F; Akman, Steven A; Torti, Frank M; Torti, Suzy V; Laubenbacher, Reinhard PLoS computational biology 2017 Feb;13(2):e1005352 Effects of research complexity and competition on the incidence and growth of coauthorship in biomedicine.Brunson, Jason Cory; Wang, Xiaoyan; Laubenbacher, Reinhard C PloS one 2017 Jan;12(3):e0173444 Optimization and Control of Agent-Based Models in Biology: A Perspective.An, G; Fitzpatrick, B G; Christley, S; Federico, P; Kanarek, A; Neilan, R Miller; Oremland, M; Salinas, R; Laubenbacher, R; Lenhart, S Bulletin of mathematical biology 2016 Nov; AlgoRun: a Docker-based packaging system for platform-agnostic implemented algorithms.Hosny, Abdelrahman; Vera-Licona, Paola; Laubenbacher, Reinhard; Favre, Thibauld Bioinformatics (Oxford, England) 2016 Aug;32(15):2396-8 A computational model of invasive aspergillosis in the lung and the role of iron.Oremland, Matthew; Michels, Kathryn R; Bettina, Alexandra M; Lawrence, Chris; Mehrad, Borna; Laubenbacher, Reinhard BMC systems biology 2016 Jan;10(1):34 Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis.Tsurutani, Naomi; Mittal, Payal; St Rose, Marie-Clare; Ngoi, Soo Mun; Svedova, Julia; Menoret, Antoine; Treadway, Forrest B; Laubenbacher, Reinhard; Suárez-Ramírez, Jenny E; Cauley, Linda S; Adler, Adam J; Vella, Anthony T Journal of immunology (Baltimore, Md. : 1950) 2015 Nov; A network biology approach to denitrification in Pseudomonas aeruginosa.Arat, Seda; Bullerjahn, George S; Laubenbacher, Reinhard PloS one 2015 Jan;10(2):e0118235 Iron acquisition and oxidative stress response in aspergillus fumigatus.Brandon, Madison; Howard, Brad; Lawrence, Christopher; Laubenbacher, Reinhard BMC systems biology 2015 Jan;9(1):19 An algebra-based method for inferring gene regulatory networks.Vera-Licona, Paola; Jarrah, Abdul; Garcia-Puente, Luis David; McGee, John; Laubenbacher, Reinhard BMC systems biology 2014 Mar;8(37):37 The genome-wide early temporal response of Saccharomyces cerevisiae to oxidative stress induced by cumene hydroperoxide.Sha, Wei; Martins, Ana M; Laubenbacher, Reinhard; Mendes, Pedro; Shulaev, Vladimir PloS one 2013 Sep;8(9):e74939 Stabilizing gene regulatory networks through feedforward loops.Kadelka, C; Murrugarra, D; Laubenbacher, R Chaos (Woodbury, N.Y.) 2013 Jun;23(2):025107 Modeling stochasticity and variability in gene regulatory networks.Murrugarra, David; Veliz-Cuba, Alan; Aguilar, Boris; Arat, Seda; Laubenbacher, Reinhard EURASIP journal on bioinformatics & systems biology 2012 Jan;2012(1):5 The Number of Multistate Nested Canalyzing FunctionsD. Murrugarra and R. Laubenbacher Physica D 2012 Jan;241(10):929-938 A mathematical framework for agent based models of complex biological networks.Hinkelmann, Franziska; Murrugarra, David; Jarrah, Abdul Salam; Laubenbacher, Reinhard Bulletin of mathematical biology 2011 Jul;73(7):1583-602 Modelling cell lineage using a meta-Boolean tree model with a relation to gene regulatory networks.Larsson, Jan-Ke; Wadstr?mer, Niclas; Hermanson, Ola; Lendahl, Urban; Forchheimer, Robert Journal of theoretical biology 2011 Jun;268(1):62-76 ADAM: analysis of discrete models of biological systems using computer algebra.Hinkelmann, Franziska; Brandon, Madison; Guang, Bonny; McNeill, Rustin; Blekherman, Grigoriy; Veliz-Cuba, Alan; Laubenbacher, Reinhard BMC bioinformatics 2011 Jan;12295 Bioinformatics tools for cancer metabolomicsG. Blekherman, R. Laubenbacher, D. Cortes, P. Mendes, F. Torti, S. Akman, S. Torti,and V. Shulaev Metabolomics 2011 Jan;7(3):329- 243 Boolean models of bistable biological systemsF. Hinkelmann and R. Laubenbacher Discrete and Cont. Dynamical Systems 2011 Jan;4(6):1414-1456 Regulatory patterns in molecular interaction networksD. Murrugarra and R. Laubenbacher J. Theor. Bioi. 2011 Jan;28866-72 High-order nonlinearity of silica-gold nanoshells in chloroform at 1560 nm.Falc?o-Filho, E L; Barbosa-Silva, R; Sobral-Filho, R G; Brito-Silva, A M; Galembeck, A; de Araújo, Cid B Optics express 2010 Oct;18(21):21636-44 Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import.Prestele, Jakob; Hierl, Georg; Scherling, Christian; Hetkamp, Stefan; Schwechheimer, Claus; Isono, Erika; Weckwerth, Wolfram; Wanner, Gerhard; Gietl, Christine Proceedings of the National Academy of Sciences of the United States of America 2010 Aug;107(33):14915-20 The dynamics of conjunctive and disjunctive Boolean network models.Jarrah, Abdul Salam; Laubenbacher, Reinhard; Veliz-Cuba, Alan Bulletin of mathematical biology 2010 Aug;72(6):1425-47 Discretization of time series dataE. Dimitrova, P. Vera-Licona, J. McGee, R. Laubenbacher J. Compo BioI. 2010 Jan;17(6):853-868 Polynomial Algebra of Discrete Models in Systems BiologyA. Veliz-Cuba, A.S. Jarrah, R. Laubenbacher Bioinformatics 2010 Jan;261637-1643 On the robustness of update schedules in Boolean networks.Aracena, J; Goles, E; Moreira, A; Salinas, L Bio Systems 2009 Jul;97(1):1-8