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Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.Karuppagounder, Saravanan S; Alim, Ishraq; Khim, Soah J; Bourassa, Megan W; Sleiman, Sama F; John, Roseleen; Thinnes, Cyrille C; Yeh, Tzu-Lan; Demetriades, Marina; Neitemeier, Sandra; Cruz, Dana; Gazaryan, Irina; Killilea, David W; Morgenstern, Lewis; Xi, Guohua; Keep, Richard F; Schallert, Timothy; Tappero, Ryan V; Zhong, Jian; Cho, Sunghee; Maxfield, Frederick R; Holman, Theodore R; Culmsee, Carsten; Fong, Guo-Hua; Su, Yijing; Ming, Guo-Li; Song, Hongjun; Cave, John W; Schofield, Christopher J; Colbourne, Frederick; Coppola, Giovanni; Ratan, Rajiv R Science translational medicine 2016 Mar;8(328):328ra29 Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis.Cao, Zhongwei; Lis, Raphael; Ginsberg, Michael; Chavez, Deebly; Shido, Koji; Rabbany, Sina Y; Fong, Guo-Hua; Sakmar, Thomas P; Rafii, Shahin; Ding, Bi-Sen Nature medicine 2016 Jan; PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function.Chen, Ying; Zhang, Hai-Sheng; Fong, Guo-Hua; Xi, Qiu-Lei; Wu, Guo-Hao; Bai, Chen-Guang; Ling, Zhi-Qiang; Fan, Li; Xu, Yi-Ming; Qin, Yan-Qing; Yuan, Tang-Long; Sun, Heng; Fang, Jing The Journal of biological chemistry 2015 Jun;290(33):20580-9 Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.Souma, Tomokazu; Nezu, Masahiro; Nakano, Daisuke; Yamazaki, Shun; Hirano, Ikuo; Sekine, Hiroki; Dan, Takashi; Takeda, Kotaro; Fong, Guo-Hua; Nishiyama, Akira; Ito, Sadayoshi; Miyata, Toshio; Yamamoto, Masayuki; Suzuki, Norio Journal of the American Society of Nephrology : JASN 2015 Jun; Potential contributions of intimal and plaque hypoxia to atherosclerosis.Fong, Guo-Hua Current atherosclerosis reports 2015 Jun;17(6):510 Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.Tojo, Yutaka; Sekine, Hiroki; Hirano, Ikuo; Pan, Xiaoqing; Souma, Tomokazu; Tsujita, Tadayuki; Kawaguchi, Shin-ichi; Takeda, Norihiko; Takeda, Kotaro; Fong, Guo-Hua; Dan, Takashi; Ichinose, Masakazu; Miyata, Toshio; Yamamoto, Masayuki; Suzuki, Norio Molecular and cellular biology 2015 May;35(15):2658-72 Deletion of prolyl hydroxylase domain proteins (PHD1, PHD3) stabilizes hypoxia inducible factor-1 alpha, promotes neovascularization, and improves perfusion in a murine model of hind-limb ischemia.Rishi, Muhammad T; Selvaraju, Vaithinathan; Thirunavukkarasu, Mahesh; Shaikh, Inam A; Takeda, Kotaro; Fong, Guo-Hua; Palesty, J Alexander; Sanchez, Juan A; Maulik, Nilanjana Microvascular research 2015 Jan;97181-8 PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation.Qi, Y; Liu, J; Saadat, S; Tian, X; Han, Y; Fong, G-H; Pandolfi, P P; Lee, L Y; Li, S Cell death and differentiation 2014 Nov;22(5):875-84 Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.Duan, Li-Juan; Takeda, Kotaro; Fong, Guo-Hua The American journal of pathology 2014 Feb;184(4):1240-50 Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.Takeda, Kotaro; Duan, Li-Juan; Takeda, Hiromi; Fong, Guo-Hua The American journal of pathology 2014 Jan;184(3):686-96 CD13 promotes mesenchymal stem cell-mediated regeneration of ischemic muscle.Rahman, M Mamunur; Subramani, Jaganathan; Ghosh, Mallika; Denninger, Jiyeon K; Takeda, Kotaro; Fong, Guo-Hua; Carlson, Morgan E; Shapiro, Linda H Frontiers in physiology 2014 Jan;4402 Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors.Duan, Li-Juan; Takeda, Kotaro; Fong, Guo-Hua PloS one 2014 Jan;9(1):e84736 CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury.Rahman, M Mamunur; Ghosh, Mallika; Subramani, Jaganathan; Fong, Guo-Hua; Carlson, Morgan E; Shapiro, Linda H Stem cells (Dayton, Ohio) 2013 Dec;32(6):1564-77 PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis.Criscimanna, Angela; Duan, Li-Juan; Rhodes, Julie A; Fendrich, Volker; Wickline, Emily; Hartman, Douglas J; Monga, Satdarshan P S; Lotze, Michael T; Gittes, George K; Fong, Guo-Hua; Esni, Farzad Cancer research 2013 Aug;73(15):4781-90 Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α.Matsushima, Shouji; Kuroda, Junya; Ago, Tetsuro; Zhai, Peiyong; Ikeda, Yoshiyuki; Oka, Shinichi; Fong, Guo-Hua; Tian, Rong; Sadoshima, Junichi Circulation research 2013 Apr;112(8):1135-49 Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice.Ho, Vivienne C; Duan, Li-Juan; Cronin, Chunxia; Liang, Bruce T; Fong, Guo-Hua Circulation 2012 Aug;126(6):741-52 PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response.Xie, Liang; Pi, Xinchun; Mishra, Ashutosh; Fong, Guohua; Peng, Junmin; Patterson, Cam The Journal of clinical investigation 2012 Aug;122(8):2827-36 Prostate specific membrane antigen (PSMA) regulates angiogenesis independently of VEGF during ocular neovascularization.Grant, Christina L; Caromile, Leslie A; Ho, Vivienne; Durrani, Khayyam; Rahman, M Mamunur; Claffey, Kevin P; Fong, Guo-Hua; Shapiro, Linda H PloS one 2012 Jul;7(7):e41285 Silencing Prolyl Hydroxylase Domain Protein 3 Stabilizes Hypoxia Inducible Factor -1 Alpha and Preserves Myocardial Function Through The Activation of Pro-Angiogenic and Anti-Apoptotic Pathway Following Myocardial Injury In MiceOriowo B, Thirunavukkarasu M, Selvaraju V, Adluri S, Zhan L, Takeda K, Fong G-H, Sanchez JA, and N Maulik. Current Pharmaceutical Design 2012 Jan; Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice. Adluri, Ram Sudheer; Thirunavukkarasu, Mahesh; Dunna, Nageswara Rao; Zhan, Lijun; Oriowo, Babatunde; Takeda, Kotaro; Sanchez, Juan A; Otani, Hajime; Maulik, Gautam; Fong, Guo-Hua; Maulik, Nilanjana Antioxidants & redox signaling 2011 Oct;15(7):1789-97 Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice.Duan, Li-Juan; Takeda, Kotaro; Fong, Guo-Hua The American journal of pathology 2011 Apr;178(4):1881-90 Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice.Li, Xiping; Sutherland, Scott; Takeda, Kotaro; Fong, Guo-Hua; Lee, Frank S Blood cells, molecules & diseases 2010 Jun;45(1):9-19 Efficient derivation of alveolar type II cells from embryonic stem cells for in vivo application.Roszell, Blair; Mondrinos, Mark J; Seaton, Ariel; Simons, Donald M; Koutzaki, Sirma H; Fong, Guo-Hua; Lelkes, Peter I; Finck, Christine M Tissue engineering. Part A 2009 Nov;15(11):3351-65