研究领域
My research focuses on defining the intracellular communication networks that promote specificity in signal transduction. In particular, we work on A-kinase-anchoring proteins (AKAPs) that target the camp-dependent protein kinase, as well as other signaling enzymes, into discrete signaling complexes in order to regulate the phosphorylation of target proteins. In particular, we are concentrating on AKAP complexes in the heart, and how they regulate cardiac physiology
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Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Rigatti, Marc; Le, Andrew V; Gerber, Claire; Moraru, Ion I; Dodge-Kafka, Kimberly L Cellular signalling 2015 May;27(9):1807-15
RSK3: A regulator of pathological cardiac remodeling. Martinez, Eliana C; Passariello, Catherine L; Li, Jinliang; Matheson, Christopher J; Dodge-Kafka, Kimberly; Reigan, Philip; Kapiloff, Michael S IUBMB life 2015 May;67(5):331-7
Analysis of AKAP7γ Dimerization. Singh, Arpita; Rigatti, Marc; Le, Andrew V; Carlson, Cathrine R; Moraru, Ion I; Dodge-Kafka, Kimberly L Journal of signal transduction 2015 Jan;2015371626
P2X4 receptor-eNOS signaling pathway in cardiac myocytes as a novel protective mechanism in heart failure. Yang, Ronghua; Beqiri, Dardan; Shen, Jian-Bing; Redden, John M; Dodge-Kafka, Kimberly; Jacobson, Kenneth A; Liang, Bruce T Computational and structural biotechnology journal 2015 Jan;131-7
mAKAP-a master scaffold for cardiac remodeling. Passariello, Catherine L; Li, Jinliang; Dodge-Kafka, Kimberly; Kapiloff, Michael S Journal of cardiovascular pharmacology 2014 Dec;65(3):218-25
The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Kritzer, Michael D; Li, Jinliang; Passariello, Catherine L; Gayanilo, Marjorie; Thakur, Hrishikesh; Dayan, Joseph; Dodge-Kafka, Kimberly; Kapiloff, Michael S Circulation. Heart failure 2014 Jul;7(4):663-72
Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure. Yang, Tiehong; Shen, Jian-bing; Yang, Ronghua; Redden, John; Dodge-Kafka, Kimberly; Grady, James; Jacobson, Kenneth A; Liang, Bruce T Circulation. Heart failure 2014 Mar;7(3):510-8
Scaffold state switching amplifies, accelerates, and insulates protein kinase C signaling. Greenwald, Eric C; Redden, John M; Dodge-Kafka, Kimberly L; Saucerman, Jeffrey J The Journal of biological chemistry 2013 Dec;289(4):2353-60
Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes. Li, Jinliang; Vargas, Maximilian A X; Kapiloff, Michael S; Dodge-Kafka, Kimberly L Experimental cell research 2013 Feb;319(4):447-54
Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy. Li, Jinliang; Kritzer, Michael D; Michel, Jennifer J Carlisle; Le, Andrew; Thakur, Hrishikesh; Gayanilo, Marjorie; Passariello, Catherine L; Negro, Alejandra; Danial, Joshua B; Oskouei, Behzad; Sanders, Michael; Hare, Joshua M; Hanauer, Andre; Dodge-Kafka, Kimberly; Kapiloff, Michael S Circulation research 2013 Jan;112(1):128-39
Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms. Redden, John M; Le, Andrew V; Singh, Arpita; Federkiewicz, Kyle; Smith, Samantha; Dodge-Kafka, Kimberly L The Biochemical journal 2012 Sep;446(2):301-9
Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation. Vargas, Maximilian A X; Tirnauer, Jennifer S; Glidden, Nicole; Kapiloff, Michael S; Dodge-Kafka, Kimberly L Cellular signalling 2012 Aug;24(8):1496-503
AKAPs: the architectural underpinnings of local cAMP signaling. Kritzer, Michael D; Li, Jinliang; Dodge-Kafka, Kimberly; Kapiloff, Michael S Journal of molecular and cellular cardiology 2012 Feb;52(2):351-8
LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation. Mian, Isma; Pierre-Louis, Willythssa Stéphie; Dole, Neha; Gilberti, Renée M; Dodge-Kafka, Kimberly; Tirnauer, Jennifer S PloS one 2012 Jan;7(2):e31583
A-kinase anchoring proteins: scaffolding proteins in the heart. Diviani, Dario; Dodge-Kafka, Kimberly L; Li, Jinliang; Kapiloff, Michael S American journal of physiology. Heart and circulatory physiology 2011 Nov;301(5):H1742-53
AKAP phosphatase complexes in the heart. Redden, John M; Dodge-Kafka, Kimberly L Journal of cardiovascular pharmacology 2011 Oct;58(4):354-62
Identification of AKAP79 as a protein phosphatase 1 catalytic binding protein. Le, Andrew V; Tavalin, Steven J; Dodge-Kafka, Kimberly L Biochemistry 2011 Jun;50(23):5279-91
The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity. Singh, Arpita; Redden, John M; Kapiloff, Michael S; Dodge-Kafka, Kimberly L Molecular pharmacology 2011 Mar;79(3):533-40
Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. Habrukowich, Cheryl; Han, David K; Le, Andrew; Rezaul, Karim; Pan, Wei; Ghosh, Mallika; Li, Zaiguo; Dodge-Kafka, Kimberly; Jiang, Xuejun; Bittman, Robert; Hla, Timothy The Journal of biological chemistry 2010 Aug;285(35):26825-31
cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3. Dodge-Kafka, Kimberly L; Bauman, Andrea; Mayer, Nicole; Henson, Edward; Heredia, Lorena; Ahn, Jung; McAvoy, Thomas; Nairn, Angus C; Kapiloff, Michael S The Journal of biological chemistry 2010 Apr;285(15):11078-86
The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin. Li, Jinliang; Negro, Alejandra; Lopez, Johanna; Bauman, Andrea L; Henson, Edward; Dodge-Kafka, Kimberly; Kapiloff, Michael S Journal of molecular and cellular cardiology 2010 Feb;48(2):387-94
Signalosomes as therapeutic targets Negro A., Dodge-Kafka K., Kapiloff M.S. Progress in Pediatric Cardiology 2008 Jan;25(1):51-56
Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Michel, Jennifer J Carlisle; Townley, Ian K; Dodge-Kafka, Kimberly L; Zhang, Fang; Kapiloff, Michael S; Scott, John D Molecular cell 2005 Dec;20(5):661-72
The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. Pare, Genevieve C; Bauman, Andrea L; McHenry, Molly; Michel, Jennifer J Carlisle; Dodge-Kafka, Kimberly L; Kapiloff, Michael S Journal of cell science 2005 Dec;118(Pt 23):5637-46
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Dodge-Kafka, Kimberly L; Soughayer, Joseph; Pare, Genevieve C; Carlisle Michel, Jennifer J; Langeberg, Lorene K; Kapiloff, Michael S; Scott, John D Nature 2005 Sep;437(7058):574-8
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