个人简介
Post-Doctoral Associate, 1997-2001, Oregon Health & Sciences University, Molecular & Medical Genetics, Portland, OR, Laboratory of R. Michael Liskay, Ph.D.
Ph.D., 1997, Cell and Molecular Biology, University of Pennsylvania
A.B., 1990, Biology, College of the Holy Cross
研究领域
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Dr. Deschênes’ research interests focus on studying telomere dynamics and heavy metal tolerance in Limulus polyphemus, the American horseshoe crab. Telomeres in many species are known to shorten with age, but telomere dynamics have yet to be reported for the horseshoe crab. Therefore, we are investigating the telomere sequence and length fluctuations of telomeres in individuals of different ages. Ultimately, our findings may impact our understanding of the age structure of the Long Island Sound population of Limulus. A second project in the laboratory involves identifying the molecular processes by which horseshoe crabs protect themselves against heavy metal toxicity. While many marine invertebrates are highly susceptible to pollutants, especially heavy metals, Limulus is surprisingly tolerant to these chemical insults, except at early developmental stages. We are particularly interested in determining whether oxidative damage is apparent in metal-exposed horseshoe crab embryos, and assessing the roles of various enzymes and proteins in the heavy metal response.
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