个人简介
Kyle was born in Fullerton, California and received his undergraduate degree in biochemistry from Pomona College, where he worked with Professor E.J. Crane. In 2005, he began his doctoral studies on outer-sphere effects on the copper sites of Azurin with Professor Harry Gray at the California Institute of Technology. He then moved to Cornell University for his postdoctoral work with Professor Serena DeBeer, studying the electronic structure and speciation of synthetic and bioinorganic species, most notably the iron-molybdenum cofactor of Nitrogenase. Kyle began his independent career at Cornell University in 2012 and was promoted to Associate Professor with tenure in 2018.
Kyle was recently recognized by the US Department of Energy’s Office of Science as a rising star in the field of physical biosciences; he was also recently named a Kavli Fellow (2018). His awards and honors include the Paul Saltman Award (2018), the Alfred P. Sloan Research Fellowship (2017), the National Science Foundation CAREER Award (2015), the Department of Energy Early Career Award (2105) and a spot on Forbes’ 30 Under 30 list (2013).
Education
California Institute of Technology Pasadena, CA
Ph.D., Chemistry October 1, 2010
“Outer-Sphere Effects on the Copper Sites of Pseudomonas aeruginosa Azurins.”
Pomona College Claremont, CA
B.A., Molecular Biology with Distinction, magna cum laude May 15, 2005
“Mechanistic Swing”
Honors and Awards
Paul Saltman Award 2018
Alfred P. Sloan Research Fellowship 2017
National Science Foundation CAREER Award 2015
Department of Energy Office of Science Early Career Award 2015
Forbes 30 Under 30: Science and Health 2013
John Stauffer Scholarship for Academic Merit (Pomona College) 2005
Walter Bertsch Prize in Molecular Biology (Pomona College) 2005
NSF Graduate Research Fellowship 2005
Phi Beta Kappa 2005
Barry Goldwater Scholarship 2004
Pfizer Summer Undergraduate Research Fellowship 2004
近期论文
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Activation of Dioxygen by a Mononuclear Nonheme Iron Complex: Sequential Peroxo, Oxo, and Hydroxo Intermediates Gordon, J.B.; Vilbert, A.C.; DiMucci, I.M.; MacMillan, S.N.; Lancaster, K.M.; Moënne-Loccoz, P.; Goldberg, D.P. J. Am. Chem. Soc. 2019, Articles ASAP.
Masked Radicals: Iron Complexes of Trityl, Benzophenone, and Phenylacetylene MacLeod, K.C.; DiMucci, I.M.; Zovinka, E.P.; McWilliams, S.F.; Mercado, B.Q.; Lancaster, K.M.; Holland, P.L. Organometallics 2019, Articles ASAP.
Synthesis of a copper-supported triplet nitrene complex pertinent to copper-catalyzed amination Carsch, K.M.; DiMucci, I.M.; Iovan, D.A.; Li, A.; Zheng, S.; Titus, C.J.; Lee, S.J.; Irwin, K.D.; Nordlund, D.; Lancaster, K.M.; Betley, T.A. Science 2019, 365, 1138-1143.
The 4-Electron Cleavage of a N═N Double Bond by a Trimetallic TiNi2 Complex Dunn, P.L.; Chatterjee, S.; MacMillan, S.N.; Pearce, A.J.; Lancaster, K.M.; Tonks, I.A. Inorg. Chem. 2019, 158, 11762-11772.
Celebrating the Year of the Periodic Table: Emerging Investigators in Inorganic Chemistry Dempsey, J.L.; Lancaster, K.M. Inorg. Chem. 2019, 58, 10433-10435.
A di-iron protein recruited as an Fe[II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron-peroxy species Muok, A.R.; Yijie Deng, Y.; Vadim M. Gumerov, V.M.; Jenna E. Chong, J.E.; Jennifer R. DeRosa, J.R.; Kurniyati, K.; Rachael E. Coleman, R.E.; Lancaster, K.M.; Li, C; Zhulin, I.B.; Crane, B.R. Proc. Natl. Acad. Sci. 2019, 116, 114955–14960.
A Mononuclear, Nonheme FeII–Piloty’s Acid (PhSO2NHOH) Adduct: An Intermediate in the Production of {FeNO}7/8 Complexes from Piloty’s Acid Confer, A.M.; Vilbert, A.C.; Dey, A.; Lancaster, K.M.; Goldberg, D.P. J. Am. Chem. Soc. 2019, 141, 7046–7055.
Scrutinizing metal–ligand covalency and redox non-innocence via nitrogen K-edge X-ray absorption spectroscopy Lukens, J.T.; DiMucci, I.M.; Kurogi, T.; Mindiola, D.J.; Lancaster, K.M. Chem. Sci. 2019, 10, 5044–5055.
Enhanced Fe-Centered Redox Flexibility in Fe–Ti Heterobimetallic Complexes Moore, J.T.; Chatterjee, S.; Tarrago, M.; Clouston, L.J.; Sproules, S.; Bill, E.; Bernales, V.; Gagliardi, L.; Ye, S.; Lancaster, K.M.; Lu, C.C. Inorg. Chem. 2019, Article ASAP.
An Approach to Carbide-Centered Cluster Complexes Reinholdt, A.; Majer, S.H.; Gelardi, R.M.; MacMillan, S.N.; Hill, A.F.; Wendt, O.F.; Lancaster, K.M.; Bendix, J. Inorg. Chem. 2019, Article ASAP.
Editorial overview: Emergent lessons from the elements of life Lancaster, K.M. Curr. Opin. Chem. Biol. 2019, 49, XX-XX.
Controlling a burn: outer-sphere gating of hydroxylamine oxidation by a distal base in cytochrome P460 Smith, M.A.; Majer, S.H.; Vilbert, A.C.; Lancaster, K.M. Chem. Sci. 2019, Ahead of Print.
A Nonheme Thiolate-Ligated Cobalt Superoxo Complex: Synthesis and Spectroscopic Characterization, Computational Studies, and Hydrogen Atom Abstraction Reactivity Gordon, J.B.; Vilbert, A.C.; Siegler, M.A.; Lancaster, K.M.; Moënne-Loccoz, P.; Goldberg, D.P. J. Am. Chem. Soc. 2019, 141, 3641–3653.
Reduction of CO2 by a masked two-coordinate cobalt(I) complex and characterization of a proposed oxodicobalt(II) intermediate Roy, L.; Al-Afyouni, M.H.; DeRosha, D.E.; Mondal, B.; DiMucci, I.M.; Lancaster, K.M.; Shearer, J.; Bill, E.; Brennessel, W.W.; Neese, F.; Ye, S.; Holland, P.L. Chem. Sci. 2019, 10, 918–929.
Azaallyl-derived ring formation via redox coupling in first row transition metals Hulley, E.B.; Heins, S.P.; Wolczanski, P.T.; Lancaster, K.M.; Lobkovsky, E.B. Polyhedron 2019, 158, 225–233.
Dramatic Electronic Perturbations of CuA Centers via Subtle Geometric Changes Leguto, A.J.; Smith, M.A.; Morgada, M.N.; Zitare, U.A.; Murgida, D.H.; Lancaster, K.M.; Vila, A.J. J. Am. Chem. Soc. 2018, 141, 1373–1387.
Revving up an artificial metalloenzyme Lancaster, K.M. Science 2018, 361, 1071–1072.
Electrochemical Azidooxygenation of Alkenes Mediated by a TEMPO–N3 Charge-Transfer Complex Siu, J.C.; Sauer, G.S.; Saha, A.; Macey, R.L.; Fu, N.; Chauviré, T.; Lancaster, K.M.; Lin, S. J. Am. Chem. Soc. 2018, 140, 12511–12520.
Chalcogen Impact on Covalency within Molecular [Cu3(μ3-E)]3+ Clusters (E = O, S, Se): A Synthetic, Spectroscopic, and Computational Study Cook, B.J.; Di Francesco, G.N.; Ferreira, R.B.; Lukens, J.T.; Silberstein, K.E.; Keegan, B.C.; Catalano, V.J.; Lancaster, K.M.; Shearer, J.; Murray, L.J. Inorg. Chem. 2018, 57, 11382–11392.
A Nonheme Sulfur‐Ligated {FeNO}6 Complex and Comparison with Redox‐Interconvertible {FeNO}7 and {FeNO}8 Analogues Dey, A.; Confer, A.M.; Vilbert, A.C.; Moënne‐Loccoz, P.; Lancaster, K.M.; Goldberg, D.P. Angew. Chem. Int. Ed. 2018, 57, 13465–13469.