陈西广 - 中国海洋大学 - 海洋生命学院

个人简介

2003—现在：中国海洋大学海洋生命学院生物化学与生物材料研究室，教授，博士研究生导师，海洋生物系系主任； 2000-2002:韩国大学(Korea University) 生命工学院合作研究并攻读博士学位；1999.10-12:德国格丁根大学有机化学研究所做政府间交流学者； 1998-1999:访问新加坡 MarinEx（私人）公司任海洋药物合作研究专家； 1988-2000:中国海洋大学海洋生命学院助教-讲师- 副教授，并兼任生物工程系副系主任、系主任； 1985-1988:东北师范大学有机化学-生物化学专业攻读硕士研究生。青岛市技术拔尖人才，国家自然基金委项目评审专家组成员，山东省生物化学与海洋生物材料高校重点实验室主任、山东省中韩海洋生物材料国际合作研究中心主任，《海洋通讯》编委，青岛市甲壳质研究会副理事长。主持和完成国家科技部国际合作研究项目5项；国家‘863’项目1项；国家自然科学基金4项；韩国政府‘BK21’项目1项；教育部博士点基金2项;教育部留学回国基金1项；山东省攻关项目2项；山东省优秀科学家奖励基金1项；还参与完成各级政府项目10项，与企业合作开发或转让项目等20余项。作为首位人员获得教育部科技进步2等奖、国家海洋局科技成果2等奖、山东省高校自然科学1等奖、青岛市技术发明2等奖等共8项。获得技术发明专利16项，包括1项美国专利。已发表学术论文181篇，其中SCI论文120篇。

研究领域

从事海洋生物材料研究和纳米生物技术研究。1）皮肤组织修复生物材料研究，用壳聚糖和羧甲基壳聚糖等研制C-P-C结构的不对称生物膜，用于皮肤创伤组织再生修复研究，开展抑菌、药物缓释、促进创伤愈合和抑制瘢痕增生等生物功效和分子机制研究, 研发软组织创伤修复新型生物材料 2）纳米生物载体技术研究，用海洋生物大分子进行结构修饰，研究纳米载体的制备技术、靶向技术、载药技术、细胞和组织中输运过程，研究纳米材料与细胞和生物组织之间的相互作用，评价纳米尺度下载体的生物安全性和功效，创造新型纳米药物 3）水凝胶类生物材料，用海洋生物大分子研制温度敏感型水凝胶和pH响应性水凝胶，研究水凝胶的性能、结构和生物相容性，开展细胞三维培养研究、药物缓释研究、生物支架研究、血管栓赛研究，研究生物材料微结构、微环境与组织细胞生长之间的生物学效应，研发微创型生物医用材料

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Ming Kong*, Hyunjin Park, Xiaojie Cheng, Xiguang Chen*. Spatial–temporal event adaptive characteristics of nanocarrier drugdelivery in cancer therapy. J.Controlled Release 172 (2013) 281–291. 2. Kuikun Yang, Tingting Gao, Zixian Bao, Jing Su and Xiguang Chen*. Preparation and characterization of a novel thermosensitive nanoparticle for drug delivery in combined hyperthermia and chemotherapy. J. Mater. Chem. B, 2013, 1, 6442–6448. 3. Ming Kong∗, Hyunjin Park, Chao Feng, Lin Hou, Xiaojie Cheng, Xiguang Chen∗. Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy. Carbohydrate Polymers 94 (2013) 634–641. 4. Ya Liu, Ming Kong, Xiao Jie Cheng, Qian Qian Wang, Li Ming Jiang, Xi Guang Chen∗. Self-assembled nanoparticles based on amphiphilic chitosan derivative and hyaluronic acid for gene delivery. Carbohydrate Polymers 94 (2013) 309–316. 5. Chao Feng, Zhiguo Wang, Changqing Jiang, Ming Kong, Xuan Zhou, Yang Li, Xiaojie Cheng∗, Xiguang Chen∗. Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: In vitro and in vivo evaluation. Inter.J. Pharmaceutics 457 (2013) 158–167. 6. Fang Kui Ma, Jing Li, Ming Kong, Ya Liu, Yi An∗, Xi Guang Chen∗. Preparation and hydrolytic erosion of differently structured PLGA nanoparticles with chitosan modification. International Journal of Biological Macromolecules 54 (2013) 174– 179. 7. Qian Qian Wang, Ming Kong, Yi An, Ya Liu, Jing Jing Li, Xuan Zhou, Chao Feng, Jian Li, Shao Yan Jiang, Xiao Jie Cheng*, Xi Guang. Chen*. Hydroxybutyl chitosan thermo-sensitive hydrogel: a potential drug delivery system. J Mater Sci (2013) 48:5614–5623. 8. Kui Kun Yang, Ming Kong, Ya Nan Wei, Ya Liu, Xiao Jie Cheng, Jing Li, Hyun Jin Park, Xi Guang Chen*. Folate-modified–chitosan-coated liposomes for tumor-targeted drug delivery. J Mater Sci.2013, 48:1717–1728. 9. Ya Nan Wei, Qian Qian Wang, Ting Ting Gao, Ming Kong, Kui Kun Yang, Yi An, Shao Yan Jiang, Jian Li, Xiao Jie Cheng*, Xi Guang Chen*. 3-D culture of human umbilical vein endothelial cells with reversible thermosensitive hydroxybutyl chitosan hydrogel. J Mater Sci: Mater Med, 2013 ,24(7):1781-1787. 10.Ya Liu, Hui Di Zang, Ming Kong, Fang Kui Ma, Qi Feng Dang, Xiao Jie Cheng, Qiu Xia Ji, Xi Guang Chen∗. In vitro evaluation of mucoadhesion and permeation enhancement of polymeric amphiphilic nanoparticles. Carbohydrate Polymers. 2012,89(2): 453-460. 11.Jing Li, Ming Kong, Xiao Jie Cheng, Qi Feng Dang, Xuan Zhou, Ya Nan Wei, Xi Guang Chen∗.Preparation of biocompatible chitosan grafted poly(lactic acid) nanoparticles. Inter. J. Biological Macromolecules. 2012,51(3): 221-227. 12.Qi Feng Dang, Jing Quan Yan, Hong Lin, Xi Guang Chen∗, Cheng Sheng Liu∗, Qiu Xia Ji, Jing Jing Li. Design and evaluation of a highly porous thermosensitive hydrogel with low gelation temperature as a 3D culture system for Penaeus chinensis lymphoid cells. Carbohydrate Polymers. 2012,88(1): 361-368. 13.Ya Liu, Xiao Jie Cheng, Qi Feng Dang, Fang Kui Ma, Xi Guang Chen*, Hyun Jin Park, Bum Keun Kim∗.Preparation and evaluation of oleoyl-carboxymethy-chitosan (OCMCS) nanoparticles as oral protein carriers. J. Materials Science: Materials in Medicine. 2012,23(2): 375-384. 14.Qi Feng Dang, Shu Hua Zou, Xi Guang Chen*, Cheng Sheng Liu, Jing Jing Li, Xuan Zhou, Ya Liu and Xiao Jie Cheng. Characterizations of chitosan-based highly porous hydrogel—The effects of the solvent. J. Applied Polymer Science. Vol. 125, E88–E98 (2012). 15. Qi Feng Dang, Jing Quan Yan, Jing Jing Li, Xiao Jie Cheng, Cheng Sheng Liu, Xi Guang Chen∗. Controlled gelation temperature, pore diameter and degradation of a highly porous chitosan-based hydrogel. Carbohydrate Polymers. 2011,83(1): 171-178. 16. Xiao Yan Li, Xi Guang Chen∗, Zhong Wu Sun, Hyun Jin Park, Dong-Su Cha. Preparation of alginate/chitosan/carboxymethyl chitosan complex microcapsules and application in Lactobacillus casei ATCC 393. Carbohydrate Polymers. 2011, 83(4): 1479-1485. 17.Jing Li, Ming Kong, Xiao Jie Cheng, Jing Jing Li, Wei Fang Liu, Xi Guang Chen∗.A facile method for preparing biodegradable chitosan derivatives with low grafting degree of poly(lactic acid). Inter. J. Biological Macromolecules. 2011,49(5): 1016-1021. 18.Hui Yun Zhou∗, Yan Ping Zhang, Wei Fen Zhang, Xi Guang Chen∗. Biocompatibility and characteristics of injectable chitosan-based thermosensitive hydrogel for drug delivery. Carbohydrate Polymers. 2011,83(4): 1643-1651.