个人简介
教育经历
1982 - 1986 年：就读于山东大学生物系动物学专业，完成大学本科学业，获理学学士学位。
1986 - 1989 年：在山东大学生物系发育生物学专业攻读硕士研究生，获理学硕士学位。
1994 - 1996 年：于日本北海道大学理学部生物科学专攻发育生物学专业留学，取得留日博士学位，获理学博士学位。
工作经历
1989 - 1993 年：担任山东大学生物系教师，职位从助教晋升为讲师。
1993 - 1994 年：在中国赴日本国留学生预备学校进行日语集训，获日语二级水平证书。
1996 - 1998 年：任职于山东大学生命科学学院发育生物学研究所，职位由讲师晋升为副教授。
1999 - 2001 年：在青岛海洋大学海洋生命学院任副教授，同时担任海洋生物系副主任及党支部书记。
2001 - 2003 年：在中国海洋大学海洋生命学院任教授，并担任海洋生物系主任。
2003 - 2005 年：在中国海洋大学生命科学与技术学部海洋生命学院，任教授、博士生导师，同时担任学部主任助理、国家生命科学与技术人才培养基地常务副主任。
2005 - 2008 年：在中国海洋大学海洋生命学院，任教授、博士生导师，同时担任海洋生命学院副院长、国家生命科学与技术人才培养基地主任、国家海洋生命科学实验教学示范中心主任。
2008 - 2013 年：在中国海洋大学海洋生命学院，为三级教授、博士生导师，担任海洋生命学院副院长、国家生命科学与技术人才培养基地主任。
2013 年 - 至今：在中国海洋大学海洋生命学院，为三级教授、博士生导师，同时担任中国海洋大学角膜组织工程重点实验室主任、青岛市组织工程角膜工程技术研究中心主任。
近期论文
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1. Fan TJ, Katagiri C. The mode of action on vitelline envelope of Xenopus hatching enzyme as revealed by its two molecular forms. Zoolog Sci. 1997; 14(1): 101~104.
2. Fan TJ, Katagiri C. Properties of Hatching Enzyme from Xenopus Laevis. Eur J Biochem. 2001; 268(18): 4892-4898.
3. Fan TJ*, Wang XF. In vitro culture of embryonic cells from shrimp Penaeus chinensis. J Exp Mar Biol Ecol. 2002; 267:175-184.
4. FAN TJ *, JIN LY, WANG XF. Initiation of cartilage Cell Culture from skate, Raja porasa Günther. Mar Biotechnol. 2003; 5(1): 64-69.
5. Cong R, Sun W, Liu G, Fan T*, et al. Purification and Characterization of Phenoloxidase from clam Ruditapes philippinarum. Fish Shellfish Immunol. 2005; 18 (1): 61-70.
6. Fan TJ*, Han LH, Cong RS, Liang J. Caspase Family Proteases and Apoptosis. Acta Biochim Biophys Sin. 2005; 37(11): 719-727.
7. Li BJ, Fan TJ*, Yang LL, et al. Purification and characterization of hatching enzyme from shrimp Penaeus chinensis. Arch Biochem Biophys. 2006; 451(2): 188-193.
8. Liu G, Yang L, Fan T*, et al. Purification and Characterization of Phenoloxidase from Crab Charybdis japonica. Fish Shellfish Immunol. 2006; 20(1): 47-57.
9. Fan T*, Zhao J, Fu Y, et al. Establishment of a novel corneal endothelial cell line from domestic rabbit, Oryctolagus curiculus. Sci China Ser C-Life Sci. 2007; 50(2): 161-169.
10. Fan T*, Zhang Y, Yang L, et al. Identification and characterization of a hemocyanin-derived phenoloxidase from Crab Charybdis japonica. Comp Biochem Physiol B Biochem Mol Biol. 2009; 152(2): 144-149.
11. Fan T*, Wang D, Zhao J, et al. Establishment and characterization of a novel untransfected corneal endothelial cell line from New Zealand white rabbits. Mol Vis. 2009; 15: 1070-1078.
12. Y-B Wei , T-J Fan*, G-J Jiang, et al. A novel Heart Cell Line from Brown-marbled Grouper, Epinephelus fuscoguttatus (Forsskal), and Its Viral Susceptibility to Iridovirus. J Fish Biol. 2010; 76(5):1149-1158.
13. Fan TJ*, Ren BX, Geng XF, et al. Establishment of a turbot fin cell line and its susceptibility to turbot reddish body iridovirus. Cytotechnology. 2010; 62(3):217-223.
14. Fan T, Zhao J, Ma X, et al. Establishment of a continuous untransfected human corneal endothelial cell line and its biocompatibility to denuded amniotic membrane. Mol Vis. 2011; 17:469-480.
15. Jiang G, Xu X, Jing Y, Wang R, Fan T*. Comparative studies on sorting cells from Artemia sinica at different developmental stages for in vitro cell culture. In Vitro Cell Dev Biol-Animal. 2011; 47:341–345.
16. Fan T, Wang L, Fan X, et al. A prophenoloxidase from Artemia sinica: cDNA cloning, expression and activity analysis during early development. Fish Shellfish Immunol. 2011; 31(6):1059-1064.
17. Fan T*, Ma X, Zhao J, et al. Transplantation of tissue-engineered human corneal endothelium in cat models. Mol Vis. 2013; 19: 400-407.
18. Yu HZ, Li YH, …, Fan TJ*. Cytotoxicity of lidocaine to human corneal endothelial cells in vitro. Basic Clin Pharmacol Toxicol. 2014; 114(4): 352-359.
19. Diao JM, Pang X, …, Fan TJ*. Construction of a human corneal stromal equivalent with non-transfected human corneal stromal cells and acellular porcine corneal stromata. Exp Eye Res. 2015; 132: 216-224.
20. B Xu, J Zhao, …, T Fan*. Role of hemoglobin from blood clam Scapharca kagoshimensis beyond oxygen transport. Fish Shellfish Immunol. 2015; 44(1): 248-256.
21. Wen Q, Fan T*, Bai S, Sui Y. Cytotoxicity of proparacaine to human corneal endothelial cells in vitro. J Toxicol Sci. 2015; 40(4): 427-436.
22. Tian CL, Wen Q, Fan TJ*. Cytotoxicity of atropine to human corneal epithelial cells by inducing cell cycle arrest and mitochondrion-dependent apoptosis. Exp Toxicol Pathol. 2015; 67(10): 517-524.
23. Zhao J, Ma XY, Fan TJ*. Construction of a tissue-engineered human corneal endothelium and its transplantation in rabbit models. Turk J Biol. 2016; 40:420-429.
24. Wen Q, Fan TJ*, Tian CL. Cytotoxicity of atropine to human corneal endothelial cells by inducing mitochondrion-dependent apoptosis. Exp Biol Med (Maywood). 2016; 241(13): 1457-1465.
25. Shan M, Fan TJ*. Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway. Toxicol in Vitro. 2016; 35: 36-42.
26. Zhao J, Qiu Y, Tian CL, Fan TJ*. The cytotoxic and pro-apoptotic effects of phenylephrine on corneal stromal cells via a mitochondrion-dependent pathway both in vitro and in vivo. Exp Toxicol Pathol. 2016; 68: 409-417.
27. Fan WY, Sui YL, Fan TJ*. Proparacaine induces cytotoxicity and mitochondria-dependent apoptosis in corneal stromal cells both in vitro and in vivo. Toxicol Res. 2016; 5: 1434-1444.
28. Xu B, Zhang YN, Jing Z, Fan T*. Molecular characteristics of hemoglobins in blood clam and their immune responses to bacterial infection. Int J Biol Macromol. 2017; 99: 375-383.
29. Shen JW, Peng YY, Fan TJ*. Cytotoxic effect of latanoprost on human corneal stromal cells in vitro and its possible mechanisms. Curr Eye Res. 2017; 42(4): 534-541.
30. Fan D, Fan TJ*. Clonidine induces apoptosis of human corneal epithelial cells through death receptors-mediated, mitochondria-dependent signaling pathway. Toxicol Sci. 2017; 156(1): 252-260.
31. Xu B, Song Z, Fan T*. Construction of Anterior Hemi-Corneal Equivalents Using Nontransfected Human Corneal Cells and Transplantation in Dog Models. Artif Organs. 2017; 41(11): 1004-1016.
32. Fan TJ. Human corneal cells as an in vitro model for toxicological studies of topical ocular drugs. J Clin Exp Tox. 2017; 1(1): 1-3.
33. Jiang G, Fan T*. Sodium Ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment. Oxid Med Cell Longev. 2018; 2018: 4967318.
34. Lin Y, Yu M, Fan T*. Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells. Toxicol Lett. 2019; 320: 9-18.
35. You XG, Fan TJ, Jiang GJ*. Phenylephrine induces necroptosis and apoptosis in corneal epithelial cells dose- and time-dependently. Toxicology. 2019; 428: 152305.
36.Fan TJ, Wu SX, Jiang GJ. Apoptotic effects of norfloxacin on corneal endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2020; 393(1): 77-88.
37.Zhao J, Fan T*, Ma X, Hu X. Construction of a high cell density human corneal endothelial equivalent and its transplantation in primate models. Xenotransplantation. 2019; 26(4): e12514.
38. Su W, Zhao J, Fan TJ*. Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms. Front Pharmacol. 2020; 11: 202.
39. Jiang GJ, Li Y, You XG, Fan TJ*. Establish an In Vitro Cell Model to Explore the Impacts of UVA on Human Corneal Endothelial Wound Healing. Curr Eye Res. 2020; 45(9):1065-1073.
40. Jiang GJ, Li BB, Fan TJ*. Timolol induces necroptosis, apoptosis and senescence concentration-dependently in rabbit Limbal stem cells in vitro. Life Sci. 2021 Mar 31; 277: 119453.
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