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个人简介

B.A.(1957), Northwestern University Ph.D. (1962) University of California,Los Angeles Postdoctoral Fellow ('64-65) Ohio StateUniversity

研究领域

Organic Chemistry

Synthetic and Mechanistic Organic Chemistry Syntheses of materials related to 14-hydroxydihydrocodeinone are being explored. Gas phase kinetics, both experimental and theoretical (DFT) exploring the formation of imines is underway. Note...methyl amines can be substituted for waters.

近期论文

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D. M. Schnur, Y. H. Yuh, and D. R. Dalton, "A Molecular Mechanics Study of Amide Conformations," J. Org. Chem. 1989, 54, 3779. J. Eshraghi, J. Longo, D. R. Dalton and G. W. Harrington, "An Unusual Ring Contraction in the Formation of N-Nitrosohexamethyleneimine and N- Nitrosopiperidine from Tolazamide", Japanese J. Cancer Res. (Gann) 1990, 81, 324. L. M. Mascavage, H. Chi, S. La and D. R. Dalton, "Surface-Catalyzed Hydrochlorination of Alkenes. The Reaction of the Gases Hydrogen Chloride and 1,3-Butadiene", J. Org. Chem. 1991, 56, 595. L. M. Mascavage and D. R. Dalton, "Surface Catalyzed Hydrochlorination of 1,3-Butadiene", Tetrahedron Lett. 1991, 32, 3461. B.-C. Kao, H. Doshi, H. Reyes-Rivera, D. D. Titus, M. Yin, and D. R. Dalton, 3-Substituted 2-Pyridinecarbaldoximes", J. Heterocyclic Chem. 1991, 28, 1315. A. D. Grant, D. E. Zacharias, L. M. Mascavage, G. E. Kemmerer, and D. R. Dalton "Chloromethylation of Codeine. Isolation of a Quaternary Iodide", J. Heterocyclic Chem. 1993, 30, 553. S. Jasmin, D. R. Dalton, P. J. Carroll and B.-C. Kao, "The Synthesis and Spontaneous Resolution of 2-(3-Thioxothiazolidin-3-yl)thiazole." J. Heterocyclic Chem. 1994 31, 1079. L. M. Mascavage, F. Zhang and D. R. Dalton, "The Reaction of the Gases Hydrogen Chloride and 2-Butyne." J. Org. Chem. 1994, 59, 5048. H. M. Reyes-Rivera, R. O. Hutchins and D. R. Dalton, "2-Carbaldoximes of Pyridine 4- and 5-Carboxylic Acids." J. Heterocyclic Chem. 1995, 32, 665. Y. Huang, D. R. Dalton and P. J. Carroll, "The Efficient, Enantio- selective Synthesis of Aza Sugars from Amino Acids. 1. The polyhydroxylated Pyrrolidines". J. Org. Chem. 1997,62, 371. Y. Huang, P. E. Sonnet, P. J. Carroll, and D. R. Dalton, "Diastereoselective Diels-Alder Reactions. The Role of the Catalyst.",Tetrahedron Lett. 2000 , 41, 2519. L. M. Mascavage, Q. Lu, J. Vey, D. R. Dalton and P. J. Carroll, "Enantioselective Synthesis of Aza Sugars from Amino Acids. 2. The 3-Hydroxy-2-hydroxymethylpyrrolidines." J. Org. Chem. 2001,66, 3621. Y. Huang, P. E. Sonnet and D. R. Dalton, "Diasteroselective Diels-Alder Reactions. The Role of the Catalyst.2." Archive for Organic Chemistry (ARKIVOC), 2001 : Part (vi) Commemorative Issue in Honor of Prof. Rudolph A. Abramovitch... ARKAT-USA :for the article itself, please click here , M. L. Wilson, D. R. Dalton and P. J. Carroll, "Decoration of the Aromatic Ring of Dihydrocodeinone (Hydrocodone) and 14-Hydroxydihydrocodeinone (Oxycodone)". J. Org. Chem. 2005, 70, 6492. L. M. Mascavage, M. L. Wilson and D. R. Dalton, " Syntheses of Morphine and Codeine (1992 - 2002): Templates for Exploration of Synthetic Tools." Current Organic Synthesis , Current Organic Synthesis 2006 , 3 99. L. M. Mascavage, P. E. Sonnet and D. R. Dalton, "On the Surface-Catalyzed Reaction between the Gases 2,2-Dimethylpropanal and Methanamine. Formation of Active-Site Imines." J. Org. Chem. 2006, 71 , 3435. P.E. Sonnet, L.M. Mascavage and D.R. Dalton, "The First Steps. The Attack on the Carbonyl Carbon of Pyridoxal Cofactor in Pyridoxal- Dependent Enzymes." , Bioorg. Med. Chem. Let. 2008,18, 744. L.M. Mascavage, F. Zhang-Plasket, P.E. Sonnet and D. R. Dalton, "Gas phase surface-catalyzed HCl addition to vinylacetylene: motion along a catalytic surface. Experiment and theory." Tetrahedron 2008 , 64, 9357. L. M. Mascavage, J. Tierney, P. E. Sonnet and D. R. Dalton, "The Hoffmann-Schiff dichotomy:on the reaction between chloral and amines" Archive for Organic Chemistry (ARKIVOC), 2010 : Commemorative Issue in Honor of Dr. Bruce E. Maryanoff and Dr. Cynthia A. Maryanoff ARKAT-USA : 2010 278. For the article itself, please click here . E. J. Judge, J. J. Brady, D. Dalton and R. J. Levis, "Analysis of Pharmaceutical Compounds from Glass, Fabric, Steel, and Wood Surfaces at Atmospheric Pressure Using Spatially Resolved Nonresonant Femtosecond Laser Vaporization Electrospray Mass Spectrometry" Anal. Chem. : 2010 , 82 , 3231-3238.

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