个人简介
1985-1989 南开大学物理系获理学 学士学位
1989-1991 南开大学 工作
1991-1996 中国科学院生物物理研究所 获理学博士学位
1996-1997 中国科学院生物物理研究所 助理研究员
1997-1999 德国维尔兹堡大学 博士后
1999-至今 中国科学院生物物理研究所 研究员
2006 获得国家杰出青年科学基金
2014-至今 中国科学院大学生命学院 教授
研究领域
在“基因、脑和行为”的框架下,以果蝇为模型,采用分子遗传学、细胞生物学、神经电生理以及行为学相结合的方法,主要研究视觉信息处理以及学习记忆等认知行为的神经回路及细胞分子机制:(1)视觉学习记忆的神经回路及细胞分子机制;(2)视觉信息处理的神经机制;(3)神经系统中长非编码RNA的功能机制
近期论文
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1.Mengbo Xu, Yuanhang Xiang, Xiaojun Liu, Baoyan Bai, Runsheng Chen, Li Liu, Meixia Li (2019) Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)mβ.RNA Biology, 16:42-53.
2.Qionglin Peng, Yijin Wang, Meixia Li, DeliangYuan, Mengbo Xu, Changqing Li, Zhefeng Gong, Renjie Jiao, Li Liu (2016) cGMP-dependent protein kinase encoded by foraging regulates motor axon guidance in Drosophila by suppressing Lola function.The Journal of Neuroscience, 36(16):4635-4646.
3.Chao Guo, Yifei Du, Deliang Yuan, Meixia Li, Haiyun Gong, Zhefeng Gong, Li Liu (2014) A conditioned visual orientation requires the ellipsoid body in Drosophila.Learning & Memory, 22:56-63.
4.Jiangqu Liu, Zhefeng Gong, Li Liu (2014) γ-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABAA receptors in Drosophila.J Neurochemestry, 130:408-418.
5.Xuebo Cheng, Huoqing Jiang, Weizhe Li, Hailong Lv, Zhefeng Gong, Li Liu (2013)ten-a affects the fusion of central complex primordia in Drosophila.PLOS One, 8(2): e57129.
6.Meixia Li, Shengyun Wen, Xiangqian Guo, Baoyan Bai, Zhefeng Gong, Xiaojun Liu, Yijin Wang, Yanqiong Zhou, Xiaowei Chen, Li Liu, Runsheng Chen (2012) The novel long non-coding RNA CRG regulates Drosophila locomotor behaviour.Nucleic Acids Research, 40(22):11714-11727.
7.Yanqiong Zhou, Xiaoxiao Ji, Haiyun Gong, Zhefeng Gong, Li Liu (2012) Edge detection depends on achromatic channel in Drosophila melanogaster.Journal of Experimental Biology, 215:3478-3487.
8.Huoqing Jiang, Qinlong Hou, Zhefeng Gong, Li Liu (2011) Proteomic and transcriptomic analysis of visuallong-term memory in Drosophila melanogaster.Protein & Cell, 2(3):215-222.
9.Zhefeng Gong, Jianqu Liu, Chao Guo, Yanqiong Zhou, Yan Teng, Li Liu (2010) Two pairs of neuronsin central brain control Drosophila innate light preference.Science, 330:499-502.
10.Yan Xiong, Hailong Lv, Zhefeng Gong, Li Liu (2010) Fixation and locomotor activity are impairedby inducing tetanus toxin expressionin adult Drosophila brain.Fly,3 (4):194-203.
11.Weizhe Li, Yufeng Pan, Zhipeng Wang, Haiyun Gong, Zhefeng Gong, Li Liu (2009) Morphological characterization of single fan-shaped body neurons in Drosophila melanogaster.Cell Tissue Research, 336:509-519.
12.Yufeng Pan, Yanqiong Zhou, Chao Guo, Haiyun Gong, Zhefeng Gong, Li Liu (2009) Differential roles of the fan-shaped body and the ellipsoid body in Drosophila visual pattern memory.Learning & Memory,16:289-295.
13.Zhipeng Wang, Yufeng Pan, Weizhe Li, Huoqing Jiang, Lazaros Chatzimanolis, Jianhong Chang, Zhefeng Gong, Li Liu (2008) Visual pattern memory requires foraging function in the central complex of Drosophila.Learning & Memory, 15:133-142.
14.Gang Liu, Holger Seiler, Ai Wen, Troy Zars, Kei Ito, Reinhard Wolf, Martin Heisenberg, Li Liu (2006) Distinct memory traces for two visual features in the Drosophila brain.Nature, 439:551-556.
15.Li Liu, Reinhard Wolf, Roman Ernst, Martin Heisenberg (1999) Context generalization in Drosophila visual learning requires the mushroom bodies.Nature, 400:753-756.