个人简介
教育经历
1991-1995 武汉大学病毒系，获理学学士学位
1995-1998 北京医科大学生物物理系，获理学硕士学位
1998-2003 德国马普细胞生物学研究所/海德堡大学生物系，获博士学位
工作经历
2003-2009 美国霍华德休斯医学研究院 (HHMI)，博士后。
2009- 今 中国科学院生物物理研究所，博士生导师
主要专业职务
2015 中国科学院大学生物化学与分子生物学教研室副主任
2017 任《Genome Biology》和《JBC》 杂志编委
2018 任《中国科学：生命科学》杂志编委
近期论文
查看导师新发文章
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Ping Chen, Liping Dong, Mingli Hu, Yi-Zhou Wang, Xue Xiao, Zhongliang Zhao, Jie Yan, Peng-Ye Wang, Danny Reinberg, Ming Li#, Wei Li#, Guohong Li#. Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level. Molecular Cell. 71(2):284-293. (2018)
Yan Wang*, Haizhen Long*, Juan Yu*, Liping Dong*, Michel Wassef, Baowen Zhuo, Xia Li, Jicheng Zhao,Min Wang, Cuifang Liu, Zengqi Wen, Luyuan Chang, Ping Chen, Qian-fei Wang, Xueqing Xu, Raphael Margueron#, Guohong Li#. Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells. BMC Biol. 16(1):107.(2018)
Chaoyang Xiong*, Zengqi Wen*, Juan Yu, Jun Chen, Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu, Guohong Li#. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells. BMC Biol. 16(1):110. (2018)
Wei Li*, Ping Chen*, Juan Yu, Liping Dong, Dan Liang, Jianxun Feng, Jie Yan, Peng-Ye Wang, Qing Li, Zhiguo Zhang, Ming Li#, Guohong Li#. FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription. Molecular Cell. 64(1),120-133. (2016)
Qian Zhao*, Jiqin Zhang*, Ruoyu Chen1*, Lina Wang1*, Bo Li, Hao Cheng, Xiaoya Duan, Haijun Zhu, Wei Wei, Jiwen Li, Qihan Wu, Jing-Dong J. Han, Wenqiang Yu, Shaorong Gao, Guohong Li#, Jiemin Wong#. Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals. Nature Communications. 7,12464. (2016)
Qianglin Fang*, Ping Chen*, Mingzhu Wang, Junnan Fang, Na Yang, Guohong Li#, Rui-Ming Xu#. Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. Elife. 5,e11911. (2016)
Junnan Fang, Yuting Liu, Yun Wei, Wenqiang Deng, Zhouliang Yu, Li Huang, Yan Teng, Ting Yao, Qinglong You, Haihe Ruan, Ping Chen, Rui-Ming Xu, Guohong Li. Structural Transitions of Centromeric Chromatin Regulate the Cell Cycle-dependent Recruitment of CENP-N. Genes & Development. 29 (10),1058-73. (2015)
Zhouliang Yu*, Xiang Zhou*, Wenjing Wang, Wenqiang Deng, Junnan Fang, Hao Hu, Zichen Wang, Shangze Li, Lei Cui, Jing Shen, Linhui Zhai, Shengyi Peng, Jiemin Wong, Shuo Dong, Zengqiang Yuan, Guangshuo Ou, Xiaodong Zhang, Ping Xu, Jizhong Lou, Na Yang, Ping Chen, Rui-Ming Xu, and Guohong Li. Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres. Developmental Cell 32(1), 68-81. (2015)
Feng Song*, Ping Chen*, Dapeng Sun, Mingzhu Wang, Liping Dong, Dan Liang, Ruiming Xu, Ping Zhu# and Guohong Li#. Cryo-EM study reveals a double helix of the 30 nm chromatin fiber twisted by tetra-nucleosomal units. Science 344(6182), 376-380. (Research article, 2014）
Ping Chen*, Jicheng Zhao*, Yan Wang*, Haizhen Long, Dan Liang, Haiyong Zhao, Zengqi Wen, Wei Li, Xia Li, Li Huang, Hongli Feng, Ping Zhu, Ming Li, Qainfei Wang, and Guohong Li. H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin. Genes & Development 27(19), 2109-2124. (2013)
Chao-pei Liu*, Chaoyang Xiong*, Mingzhu Wang, Zhouliang Yu, Na Yang, Ping Chen, Zhiguo Zhang, Guohong Li# and Rui-Ming Xu#. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nature Structural and Molecular Biology. 19(12), 1287-1292. (2012)
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