郭彩霞 - 中国科学院大学

个人简介

招生方向基因组不稳定性，肿瘤发生与耐药, 出生缺陷,干细胞干细胞，衰老教育背景 1996-09--1999-09 中科院动物所博士 1991-09--1994-07 武汉大学硕士 1987-09--1991-07 武汉大学学士教授课程细胞生物学技术与应用细胞生物学技术及应用基因组学前沿基因组生物技术前沿讲座工作经历 2009/08-，中国科学院北京基因组研究所，基因组变异和精准生物医学实验室研究员；博士生导师 2008-2009，美国西南医学研究中心，病理系，研究助理教授； 2004-2008，美国西南医学研究中心，病理系，讲师； 2001-2004，美国西南医学研究中心，病理系，博士后 1999-2001，美国肯塔基大学，生理系，博士后； 1994-1996，天津农业生物工程研究中心，研究实习员（在中国农业科学院畜牧所客座）奖励中国科学院朱李月华优秀教师奖, 院级, 2016 科研项目 1，国家自然科学基金面上项目，错配修复蛋白MSH2调控跨损伤DNA合成与疾病发生研究，2015年1月到2018年12月，在研，项目负责人。 2，国家自然科学基金重点项目，非编码RNA及其互作因子表观调控DNA损伤修复研究， 2017年1月到2021年12月，在研，项目负责人。 3，国家自然科学基金面上项目， DNA聚合酶 O-GlcNAc糖基化修饰对其功能的调控研究，2017年1月到2020年12月，在研，项目负责人。 4，国家重大科学研究计划项目子课题，生殖细胞与体细胞的相互作用，2013年1月到2017年12月，在研，骨干。

研究领域

DNA损伤应答与基因组稳定性、核酸代谢与疾病、肿瘤精准医学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1 Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C*, Wang Q*, Tang TS*. The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLOS Biol. (2016). 14(11):e2000733. doi: 10.1371/journal.pbio.2000733. 2 Zhang H, Zhang C, Yan J, Sun Z, Song S, Sun Y, Guo C*. Transcriptome analysis of the responses to methyl methanesulfonate treatment in mouse pachytene spermatocytes and round spermatids. Gene. (2016). pii: S0378-1119(16)30800-9. 3 Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y, Chen Q, Zhou A, Tang TS. TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell. (2016). 165(6):1454-66. 4 Wang K, Ma X, Zhang X, Wu D, Sun C, Sun Y, Lu X, Wu CI, Guo C*, Ruan J*. Using ultra-sensitive next generation sequencing to dissect DNA damage-induced mutagenesis. Sci Rep. (2016). 6:25310. 5 Sun Y, Yang Y, Shen H, Huang M, Wang Z, Liu Y, Zhang H, Tang TS, Guo C*. iTRAQ-based chromatin proteomic screen reveals CHD4-dependent recruitment of MBD2 to sites of DNA damage. Biochem Biophys Res Commun. (2016). 471(1):142-8. 6 Wang Z, Huang M, Ma X, Li H, Tang T, Guo C*. REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18. J Cell Sci. (2016). 129:1223-1233. 7 Yan J, Zhang H, Liu Y, Zhao F, Zhu S, Xie C, Tang TS, Guo C*. Germline Deletion of Huntingtin Causes Male Infertility and Arrested Spermiogenesis in Mice. J Cell Sci. (2016). 129: 492-501. 8 Dai K, Qin F, Zhang H, Liu X, Guo C, Zhang M, Gu F, Fu L, Ma Y. Low expression of BMPRIB indicates poor prognosis of breast cancer and is insensitive to taxane-anthracycline chemotherapy. Oncotarget. (2016). 7(4):4770-84. 9 Liu Y, Ma X, Guo C*. Effects of the N terminus of mouse DNA polymerase κ on the bypass of a guanine-benzo[a]pyrenyl adduct. J Biochem. (2016).159(4):471-9. 10 Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin Y, Huang M, Zhang T, Pei H, Chen B, Jansen JG, Wind N, Fischhaber P, Friedberg EC, Tang TS and Guo C*. FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res. 43, 8325-8339 (2015). 11 Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ. CSB-PGBD3 Mutations Cause Premature Ovarian Failure. PLoS Genet. 11(7):e1005419. doi: 10.1371/journal.pgen.1005419 ( 2015). 12 Dong S, Han J, Chen H, Liu T, Huen MS, Yang Y, Guo C, Huang J. The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection. Curr Biol. 24(18):2097-110. (2014). 13 Wang F, Fischhaber PL, Guo C, Tang TS. Epigenetic modifications as novel therapeutic targets for Huntington's disease. Epigenomics. 6(3):287-97. (2014). 14 Li X, Qu F, Xie W, Wang F, Liu H, Song S, Chen T, Zhang Y, Zhu S, Wang Y, Guo C, Tang TS*. Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal. Toxicol Sci. 139(2):452-65 (2014) 15 Gao M, Wei W, Li MM, Wu YS, Ba Z, Jin KX, Li MM, Liao YQ, Adhikari S, Chong Z, Zhang T, Guo C, Tang TS, Zhu BT, Xu XZ, Mailand N, Yang YG, Qi Y, Rendtlew Danielsen JM. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. Cell Res. 24(5):532-41. (2014). 16 Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg EC, Yang W, Guo C*. Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct. Proc Natl Acad Sci USA. 111(5): 1789-1794. (2014). 17 Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C*. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acid Res. 41(22):10312-10322. (2013). 18 Bétous R, Pillaire MJ, Pierini L, van der Laan S, Recolin B, Ohl-Séguy E, Guo C, Niimi N, Grúz P, Nohmi T, Friedberg E, Cazaux C, Maiorano D, Hoffmann JS. DNA polymerase κ- dependent DNA synthesis at stalled replication forks is important for CHK1 activation. EMBO J. 32(15):2172-2185. (2013). 19 Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C*, Han C*, Tang TS*. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Human Mol Genet 22(18):3641-3653. (2013). 20 Wang J, Chen Q, Wang X, Wang Q, Wang Y, Cheng H, Guo C, Sun Q, Chen Q, Tang TS. Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington’s Disease. J. Biol. Chem. 288(5): 3070-3084. (2013). 21 Zhang X, Lv L, Chen Q, Yuan F, Zhang T, Yang Y, Zhang H, Wang Y, Jia Y, Qian L, Chen B, Zhang Y, Friedberg C, Tang T and Guo C*. Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA Repair. 12(5):377-88. (2013). 22 Wang Z,Wang F, Tang T, Guo C*. The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med. 6(2):156-164 (2012).