Hougland, James - Syracuse University - Department of Chemistry

个人简介

Lewis H. Sarrett Undergraduate Research Award, 1998 McCormick Graduate Fellowship, 1998-1999 National Institutes of Health Postdoctoral Fellowship, 2006-2009 March of Dimes Basil O'Connor Starter Scholar Research Award, 2014-2016

研究领域

Bioorganic chemistry, biochemistry, enzymology, post-translational modification, molecular biology

近期论文

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Darling, J.E.; Zhao, F.; Loftus, R. J.; Patton, L. M.; Gibbs, R. A. and J.L. Hougland. Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition. Biochemistry, 2015, 54, 1100-10 Flynn, S. C.; Lindgren, D. E. and J. L. Hougland. Quantitative determination of cellular farnesyltransferase activity: Towards defining the minimum substrate reactivity for biologically relevant protein farnesylation. ChemBioChem, 2014, 15, 2205-10 Gangopadhyay, S. A.; Losito, E. L. and Hougland, J. L. Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active site residues in protein substrate recognition. Biochemistry, 2014, 53, 434-46 Darling, J. E.; Prybolsky, E. P.; Sieburg, M. and Hougland, J. L. A fluorescent peptide substrate facilitates investigation of ghrelin recognition and acylation by ghrelin O-acyltransferase. Anal. Biochem., 2013, 437, 68-76 Hougland, J. L.; Gangopadhyay, S. A. and Fierke, C. A. Expansion of protein farnesyltransferase specificity using “tunable” active site interactions: Development of bioengineered prenylation pathways. J. Biol. Chem., 2012, 287, 38090-100 Hougland, J. L.; Hicks, K. A.; Hartman, H. L.; Kelly, R. A.; Watt, T. J. and Fierke, C. A. Identification of Novel Peptide Substrates for Protein Farnesyltransferase Reveals Two Substrate Classes With Distinct Sequence Selectivities. J. Mol. Biol., 2010, 395, 176-190 Hougland, J. L.; Hicks, K. A.; Hartman, H. L.; Kelly, R. A.; Watt, T. J.; Fierke, C. A. Identification of Novel Peptide Substrates for Protein Farnesyltransferase Reveals Two Substrate Classes with Distinct Sequence Selectivities. J. Mol. Biol., 2010, 395, 176-190. Hougland, J. L.; Lamphear, C. L.; Scott, S. A.; Gibbs, R. A. and Fierke, C. A. Context-dependent substrate recognition by protein farnesyltransferase. Biochemistry, 2009, 48, 1691-1701