个人简介
教育经历
1978-82 中国西北大学生物系 学士
1983-85 加拿大Guelph大学微生物学系 硕士
1985-88 加拿大Guelph大学微生物学系 博士
工作经历
1988-93 美国Johns Hopkins大学生物化学系 博士后
1993-96 美国Pomona学院 助理教授
1996-98 中国科学院微生物研究所 副研究员
1998-今 中国科学院微生物研究所 研究员 博士生导师
2008.4-2013.9 中国科学院微生物研究所常务副所长、所长
近期论文
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Zhang Z#, Zhao M#, Wang L, Chen Y, Dong Y, Gong Y*, Huang L*. 2017. Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA. The Biochemical journal 474:1727-1739.
Sun F, Huang L*. 2016. A euryarchaeal histone modulates strand displacement synthesis by replicative DNA polymerases. ScienceChinaLife sciences 59:709-716.
Dai X, Wang H, Zhang Z, Li K, Zhang X, Mora-Lopez M, Jiang C, Liu C, Wang L, Zhu Y, Hernandez-Ascencio W, Dong Z, Huang L*. 2016. Genome Sequencing of Sulfolobus sp. A20 fromCosta Ricaand Comparative Analyses of the Putative Pathways of Carbon, Nitrogen, and Sulfur Metabolism in Various Sulfolobus Strains. Frontiers in microbiology 7:1902.
Chu Y#, Zhu Y#, Chen Y, Li W, Zhang Z, Liu D, Wang T, Ma J, Deng H, Liu Z-J, Ouyang S*, Huang L*. 2016. aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicusbut is Dispensable for the Growth of the Organism. Molecular & cellular proteomics 15:2908-2923.
Zheng X, Liu H, Song L, Zhang L, Wang H, Dai X, Huang L*. 2015. Phaeocystidibacter marisrubri sp. nov., a member of the family Cryomorphaceae isolated fromRed Seasediment. International journal of systematic and evolutionary microbiology 65:2199-2203.
Zhang Z, Gong Y, Chen Y, Li H, Huang L*. 2015. Insights into the interaction between Cren7 and DNA: the role of loop beta3-beta4. Extremophiles 19:395-406.
Zhan Z, Zhou J, Huang L*. 2015. Site-Specific Recombination by SSV2 Integrase: Substrate Requirement and Domain Functions. Journal of virology 89:10934-10944.
Xiang X#, Huang X#, Wang H#, Huang L*. 2015. pTC Plasmids from Sulfolobus Species in the Geothermal Area ofTengchong,China: Genomic Conservation and Naturally-Occurring Variations as a Result of Transposition byMobileGenetic Elements. Life (Basel,Switzerland) 5:506-520.
Wang H, Peng N, Shah SA, Huang L*, She Q*. 2015. Archaeal extrachromosomal genetic elements.Microbiology and molecular biology reviews 79:117-152.
Liu B#, Ouyang S#, Makarova KS, Xia Q, Zhu Y, Li Z, Guo L, Koonin EV, Liu Z-J*, Huang L*. 2015. A primase subunit essential for efficient primer synthesis by an archaeal eukaryotic-type primase. Nature communications 6:7300.
Lang S, Huang L*. 2015. The Sulfolobus solfataricus GINS Complex Stimulates DNA Binding and Processive DNA Unwinding by Minichromosome Maintenance Helicase. Journal of bacteriology 197:3409-3420.
Dai X#, Tian Y#, Li J#, Luo Y, Liu D, Zheng H, Wang J, Dong Z, Hu S*, Huang L*. 2015. Metatranscriptomic analyses of plant cell wall polysaccharide degradation by microorganisms in the cow rumen. Applied and environmental microbiology 81:1375-1386.
Xing X, Zhang L, Guo L, She Q, Huang L*. 2014. Sulfolobus replication factor C stimulates the activity of DNA polymerase B1. Journal of bacteriology 196:2367-2375.
Song L#, Wang H#, Wang S, Zhang H, Cong H, Huang L*, Tien P*. 2014. Self-assembled bionanoparticles based on the Sulfolobus tengchongensis spindle-shaped virus 1 (STSV1) coat protein as a prospective bioscaffold for nanotechnological applications. Extremophiles 18:745-754.
Guo L#, Ding J#, Guo R, Hou Y, Wang D-C*, Huang L*. 2014. Biochemical and structural insights into RNA binding by Ssh10b, a member of the highly conserved Sac10b protein family in Archaea. The Journal of biological chemistry 289:1478-1490.
Erdmann S, Chen B, Huang X, Deng L, Liu C, Shah SA, Le Moine Bauer S, Sobrino CL, Wang H, Wei Y, She Q, Garrett RA, Huang L*, Lin L*. 2014. A novel single-tailed fusiform Sulfolobus virus STSV2 infecting modelSulfolobus species. Extremophiles 18:51-60.