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个人简介

学习经历 1986.9-1990.6 山东大学微生物系 本科生 1990.9-1994.9 中国科学院应用生态研究所微生物制药学 硕博连读 工作经历 1994.12-1998.6  美国爱默瑞大学药理学 博士后 1998.07-1998.12  美国爱默瑞大学药理系 助理教授 1998.12-2001.10 美国Microbia生物制药公司 Sr. Scientist 2001.10-2003.12 美国CETEK制药公司  Section Head 2004.1 -2006.2  美国SynerZ制药公司  President 2004.10-2006.2  中国科学院广州生物医药与健康研究院 研究员/博导/海洋微生物天然产物药物研究室主任 2006.2- 至今 中国科学院微生物研究所 研究员/博导/结核药物研发中心主任

研究领域

主要从事微生物天然产物库的建立、高通量活性筛选、利用合成生物学方法提高其产量和效能的研究。 

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1 专著:Zhang, L.*, and A. Demain. (Editors-in-Chief) 2005. " Natural Products: Drug Discovery, Therapeutic Medicine ", ISBN: 1-58829-383-1, Humana Press, USA 2 Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz, Michael P. Hendrich, Catherine E. Costello, Zhang L*, Pinghua Liu*, and Yan Jessie Zhang*. 2015. Endoperoxide Formation Catalyzed by FtmOx1, an α-Ketoglutarate-dependent Mononuclear Non-heme Iron Enzyme. Nature, 527, 539–543 3 Bai C, Zhang Y, Zhao X, Hu Y, Xiang S, Miao J, Lou C*, Zhang L*. 2015. Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces. Proc Natl Acad Sci U S A. 112 (39), 12181-6 4 Wang Qian#, Song Fuhang#, Xiao Xue#, Huang Pei, Li Li, Aaron Monte, Wael M. Abdel-Mageed, Wang Jian, Guo Hui, He Wenni, Xie Feng, Dai Huanqin, Liu Miaomiao, Chen Caixia, Xu Hao, Liu Mei, Andrew M. Piggott, Liu Xueting*, Robert J. Capon*, Zhang Lixin*. 2013. Abyssomicins from a South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as potential antitubercular prodrugs. Angew. Chem.-Int. Edit. 52, 1231-1234. 5 Ashforth Elizabeth Jane, Fu Chengzhang, Liu Xiangyang, Dai Huanqin, Song Fuhang, Guo Hui, Zhang Lixin*. 2010. Bioprospecting for antituberculosis leads from microbial metabolites. Nat Prod Rep. 27: 1709-1719. 6 Ying Zhuo, Wenquan Zhang, Difei Chen, Hong Gao, Jun Tao, Mei Liu, Zhongxuan Gou, Xianlong Zhou, Bangce Ye, Qing Zhang, Siliang Zhang, and L Zhang*. 2010. Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis. Proc Natl Acad Sci USA. 107: 11250-4 7 Zhang, L*., Yan K, Zhang Y, Bian J, Zheng C, Sun H, Chen Z, Sun N, Song Y, Zhuo Y, You J, et al. 2007. High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc. Natl. Acad. Sci. USA. 104(11): 4606-11 8 Zhang HM#, Dai H#, Hanson PJ, Li H, Guo H, Ye X, Hemida MG, Wang L, Tong Y, Qiu Y, Liu S, Wang F, Song F, Zhang B, Wang JG, Zhang L*, Yang D*. 2014. Antiviral Activity of an Isatin Derivative via Induction of PERK-Nrf2-mediated suppression of Cap-independent Translation. ACS Chem Biol. 9 (4), 1015–1024 9 Wang F, Wang Y, Ji J, Zhou Z, Yu J, Zhu H, Su Z, Zhang L*, Zheng J. 2015. Structural and Functional Analysis of the Loading Acyltransferase from Avermectin Modular Polyketide Synthase. ACS Chem Biol. 10 (4),1017–1025 10 Zhang, L*., An, R.; Wang, J.; Sun, N.; Zhang, S.; Hu, J.; Kuai, J. 2005. Exploring novel bioactive compounds from marine microbes. Current Opinion In Microbiology, 8(3): 276-281 11 SONG Fuhang#, LIU Xinru#, GUO Hui, REN Biao, CHEN Caixia, Andrew M. Piggott, YU Ke, GAO Hong, WANG Qian, LIU Mei, DAI Huanqin, ZHANG Lixin* and Robert J. Capon. 2012. Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor. Organic Letters, 14 (18), 4770–4773 12 Zhang Jingyu, Abdel-mageed Wael M., Liu Miaomiao, Huang Pei, He Wenni, Li Li, Song Fuhang, Dai Huanqin, Liu Xueting*, Jingyu Liang*, Zhang Lixin*. 2013. Caesanines A-D, new cassane diterpenes with unprecedented N bridge from Caesalpinia sappan. Organic Letters. 15(18), 4726-4729. 13 Chen Caixia, Liu Xueting, Abdel-Mageed Wael M, Guo Hui, Hou Weiyuan, Jaspars Marcel, Li Li, Xie Feng, Ren Biao, Wang Qian, Dai Huanqin, Song Fuhang*, Zhang Lixin *. 2013. Nivetetracyclates A and B: novel compounds isolated from Streptomyces niveus. Organic Letters. 15 (22), 5762–5765

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