曾长青 - 中国科学院大学

个人简介

学习经历： 1978-1982 北京师范大学生物学系学士学位 1982-1985 北京师范大学生物学系硕士学位 1987-1993 美国阿拉巴马大学伯明翰校区博士学位工作经历： 1985-1987 北京师范大学生物学系讲师 1994-2000 美国贝勒医学院生化与分子生物学系 Research Associate 博士后 2000-2002 美国德克萨斯大学休斯敦医学院综合生物学与药理学系助理教授 2002-2006 北京华大基因研究中心研究员科研部部长 2003-2006 北京师范大学特聘讲座教授 2003- 中科院北京基因组研究所研究员 2010-2013 中科院北京基因组研究所重大疾病和个体化医疗重点实验室主任 2014至今中科院北京基因组研究所精准基因组医学重点实验室主任

研究领域

目前主要致力于用高通量基因组和表观基因组分析以及生物信息学手段回答生物学问题，重点研究方向为肿瘤在内的疾病相关基因定位及其分子通路与调控机制分析，低氧适应等相关基因的群体遗传学研究和基因组功能注释，自然发生和疾病相关的体细胞突变研究等，同时开展精准医学如人群队列分析和肿瘤早期诊断等方面研究。

近期论文

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1. Shao, J. M., Raza, M. S., Zhuoma B. S., Zeng, C. Q*. Evolutionary significance of selected EDAR variants in Tibetan high-altitude adaptations. Science China Life Sciences. doi: 10.1007/s11427-016-9045-7 (2017) 2. Zhang, H. K., Zhao, F. X., Hutchinson, D. S. et al., Zhang, D. K.*, Zhou, X. T. Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing. Immunology and Microbiology. 58(1):128-136 (2016) 3. Li F, Zhang D, Li Y, Jiang D, Luo S, Du N, Chen W, Deng L, Zeng C*. Whole genome characterization of hepatitis B virus quasispecies with massively parallel pyrosequencing. Clinical Microbiology and Infection. (2015) Mar21 (3):280–287 4. Han X, Liu M, Wang S, Lv G, Ma L, Zeng C*, Shi Y. An Integrative Analysis of the Putative Gefitinib-resistance Related Genes in a Lung Cancer Cell Line Model System. Curr Cancer Drug Targets. (2015);15(5):423-34. 5. Xia H, Hu C, Zhang D, Tang S, Zhang Z, Kou Z, Fan Z, Bente D, Zeng C*, Li T. (2015) Metagenomic Profile of the Viral Communities in Rhipicephalus spp. Ticks from Yunnan, China. PLoS ONE 10(3): e0121609. doi:10.1371/journal.pone.0121609 6. Wu J, Li Q, Li Y, Lin J, Yang D, Zhu G, Wang L, He D, Lu G, Zeng C*. A Long Type of TBCK Is a Novel Cytoplasmic and Mitotic Apparatus-Associated Protein Likely Suppressing Cell Proliferation, Journal of Genetics and Genomics (2014), Feb 20;41(2):69-72. 7. Cheng F, Zhang X, Zhang Y, Li C, Zeng C*. Haplo2Ped: a tool using haplotypes as markers for linkage analysis, BMC Bioinformatics,(2011) 12:350. 8. Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins RA*, Shianna KV, Tam SC, Tsering N, Veeramah K, Wang W, Wangdui P, Weale ME, Xu Y, Xu Z, Yang L, Zaman MJ, Zeng C*, Zhang L, Zhang X, Zhaxi P, and Zheng YT (2010). Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. PNAS, 107 (25): 11459-11464. (* corresponding) 9. Cheng F, Chen W, Richards E, Deng L, Zeng C* (2009). SNP@Evolution: a hierarchical database of positive selection on the human genome. BMC Evol Biol, 9:221. 8. Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q, Zeng C* & Lin D* (2007). A 6-nucleotide insertion/deletion polymorphism in the promoter of CASPASE-8 gene and susceptibility to multiple types of cancer. Nat Genetics, 39(5):605-613. (* corresponding) 9. Zeng C. as one principal investigator of the International HapMap Consortium (2007). A second generation human haplotype map of over 3.1 million SNPs. Nature, 449:851-861. 10. Zeng C. as one principal investigator of the International HapMap Consortium (2007). Genome-wide detection and characterization of positive selection in human populations. Nature, 449: 913-918