Doyle, Robert - Syracuse University - Department of Chemistry

个人简介

Enterprise Ireland Fellowship, 1998 RSC Fellowship, 2002 Rudolph Anderson Foundation Fellowship, 2004 Ewing Marion Kauffman Foundation Award, 2008 ACS New Investigator Award, 2009 Tenure, February 2009 Faculty of 1000, Associate Member 2010 James K. Duah-Agyeman Award for Outstanding Faculty, 2011 Faculty Advisor of the Year, 2012 Promoted to Full Professor, 2014

研究领域

Medicinal chemistry, bioconjugate chemistry, biochemistry

近期论文

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Doyle, R. P.*, Christopher Fazen, Debbie Valentin, Timothy J. Fairchild Oral Delivery of the Appetite Suppressing Peptide hPYY3-36 through the Vitamin B12 Uptake Pathway Journal of Medicinal Chemistry, accepted DOI: 10.1021/jm2012547, available on line November 4th 2011 Doyle, R. P.*, David D. Dixson, Vivian Yaci Yu, Recombinant expression of his-tagged Saposin B for affinity purification of Coenzyme Q10 Analytical Biochemistry 419, 145-152, 2011. Doyle, R. P.*, Zubieta, J., Christopher Chu, Kari Darling, Ross Netusil, Synthesis and Structure of a Lead(II)–Citrate: {Na(H2O)3}[Pb5(C6H5O7)3(C6H6O7)(H2O)3]•9.5H2O ICA 378, 186-193, 2011. Doyle, R. P.*, Anthony R. Vortherms, Anna Kahkoska, Amy E. Rabideau, Jon Zubieta, Louise Lund Andersenb, Mette Madsen A water soluble vitamin B12-Re(I) fluorescent conjugate for cell uptake screens: Use in the detection of cubilin in the lung cancer line A549, Chem. Commun., 47(35), 9792-9794, 2011 Doyle, R. P.*, Nadia Marino, Francisco Lloret, Miguel Julve, Synthetically persistent, self assembled [VIV2VV4] polyoxovanadates: Facile synthesis, structure and magnetic analysis In Press, Dalton. Trans., 2011. (Invited- Special Issue on 'Self-assembly in Inorganic Chemistry')). Zylstra, J., Amey, J., Miska N. J., Pang, L., Hine, C.R., Langer, J., Doyle, R. P., Maye, M. M. A modular phase transfer and ligand exchange protocol for quantum dots Langmuir 2011, 19, 4371-4379. Doyle, R. P.*; Marino, N.; Fazen, C. H.; Blakemore, J. D.; Incarvito, C. D.; Hazari, N. Isostructural PdII and PtII Pyrophosphato Complexes: Polymorphism and Unusual Bond character in d8-d8 systems. Inorg. Chem. 50, 2507-2520, 2011. Doyle R. P.*; Marino, N.; Ikotun, O. F.; Julve, M.; Lloret, F.; Cano, J. PPi mediated magnetic interactions in Cu(II) coordination complexes. Inorg. Chem. 2011, 50, 378-389. Doyle, R. P.*; Marino, N.; Rabideau, A. E. TFA-assisted crystallization of vitamin B12 results in protonation of the phosphate group of the nucleotide loop: insight into the influence of crystal packing forces on vitamin B12 structures. Inorg. Chem. 2011, 50, 220-230. Doyle, R. P.*; Bartholomä, M. D.; Vortherms, A. R.; Shawn Hillier, S.; Joyal, J.; Babich, J.; Zubieta, J. Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)3 thymidine complexes. Dalton. Trans. (Special Issue on Metals in Imaging) 40, 6216-6225, 2011. Doyle, R. P.*; Clardy, S. M.; Allis, D. G.; Fairchild, T. J. Vitamin B12 in Drug Delivery: Breaking through the barriers to a B12 bioconjugate pharmaceutical. Expert Opinion on Drug Delivery (invited) 2011, 8, 127-140. Doyle, R. P.*; Dixson, D. D.; Boddy, C. N. Reinvestigation of Coenzyme Q10 isolation from Sporidiobolus johnsonii Chemistry and Biodiversity 8, 1033-1051, 2011. Doyle, R. P.*; Zubieta, J.*; Bartholomä, M. D.; Vortherms, A. R.; Hillier, S.; Ploier, B.; Joyal, J.; Babich, J. Synthesis, Cytotoxicity, and Insight into the Mode of Action of Re(CO)3 Thymidine Complexes. ChemMedChem 2010, 5, 1513 – 1529. Doyle, R. P.*; Lensbouer, J. J. Secondary Transport of Metal-citrate Complexes: The CitMHS Family. Critical reviews in Molecular Biology and Biochemistry 2010, 45(5), 453–462. Doyle, R. P.*; Allis, D. G.; Fairchild, T. J. The binding of vitamin B12 to transcobalamin(II); structural considerations for bioconjugate design. Mol. BioSyst. 2010, 6, 1611-1618. Doyle, R. P.*; Vortherms, A. R.; Marino, N.; Hoffman, A. E. Expanding Monomeric Pyrophosphate Complexes beyond Platinum. Inorg. Chem. 2010, 49, 6790–6792. Doyle, R. P.* Ikotun, O. F.; Marino, N.; Kruger, P. E.; Julve, M. Exploring the Coordination chemistry of Pyrophosphate, a Ligand of diverse Biological, Magnetic and Catalytic potential. Coord. Chem. Rev., 2010, 254, 890-915. Doyle, R. P.*; Lensbouer, J. J.; Li, Q. W.; Estlinbaum, M. R161, K452 and R460 residues are vital for metal-citrate complex transport in the CitMHS secondary transport protein CitSc from Streptomyces coelicolor. Metallomics 2010, 2, 342-347. Doyle, R. P.; Bidwell, A. J.; Holmstrup, M. E.; Fairchild, T. J.* Metabolic and Cardiovascular Responses to Fructose. Acta Physiologica 2010, 200, 35-43. Doyle, R. P.*; Viola-Villegas, N.; Rabideau, A. E.; Zubieta, J.; Bartholomä, M. Targeting the Cubilin Receptor through the Vitamin B12 Uptake Pathway; Cytotoxicity and Mechanistic Insight through Fluorescent Re(I) Delivery. J. Med. Chem. 2009, 52, 5253-5261. Doyle, R. P.*; Higbee, E. M.; Ouellette, W.; Ikotun, O. F. Pyrophosphate bridged complexes with picomolar cytotoxicity. J. Inorg. Biochem. 2009, 103, 1254-1264. Doyle, R. P.*; Vortherms, A.R.; Dang, H. Anticancer Conjugates and Cocktails based on Methotrexate and Nucleoside Synergism. Clinical Medicine: Oncology (invited) 2009, 3, 19-26. Doyle, R. P.*; Petrus, A. K.; Fairchild, T. J. Traveling the Vitamin B12 Pathway: Oral Delivery of Protein and Peptide Drugs. Angew. Chem. Int. Ed. 2009, 48, 1022-1028. Doyle, R. P.*; Petrus, A. K.; Allis, D. G.; Smith, R. P.; Fairchild, T. J. Exploring the Implications of Vitamin B12 Conjugation to Insulin on Insulin Receptor Binding. ChemMedChem 2009, 4, 421-426.