个人简介
焦建伟,博士,中国科学院动物研究所研究员,博士生导师,神经干细胞增殖与分化研究组组长,国家杰出青年科学基金获得者,中组部万人计划领军人才,科技部中青年科技创新领军人才,中科院百人计划入选者,国家重点研发计划首席科学家。
2002年在北京大学生命科学学院获得博士学位,2002年到2007年在美国哈佛医学院从事博士后研究,2008年被提升为Instructor。2009年到2011年在中科院神经所任研究员。2011年8月加入中科院动物所任研究员。实验室主要从事脑发育及疾病机理研究,神经干细胞增殖与分化调控研究,遗传和表观遗传对神经发育调控机制研究,以及神经细胞转分化研究。研究成果发表于国际期刊ScienceAdvances,PNAS,JCellBiol,NucleicAcidsRes,CellRes等共50多篇。是生理学会理事,细胞学会干细胞生物学分会委员,神经学会神经发育与再生分会委员等。承担科研项目情况:
国家杰出青年科学基金,2019-2023
国家自然科学基金重点项目,2018-2022
国家重大基础研究计划项目,2015-2019
中科院战略先导科技专项,2017-2021
研究领域
研究领域:
神经系统发育是一个受时间和空间精细调控的过程,任何一个环节出现问题,都可能引起严重的脑发育异常及相关疾病。围绕脑发育的发生发展开展系统性研究,以遗传与表观遗传调控为切入点,多角度、多层次阐释脑发育及神经干细胞增殖分化的调控机制。主要研究方向:1.探讨神经干细胞增殖机制,发现新的调控神经干细胞自我更新和增殖的关键因子,探索脑大小及脑沟回形成的关键分子及机制,研究脑发育异常的调控因素及机制;2.研究神经元及神经胶质细胞分化的调控机理,解析内源因子和外源信号通路如何协同调控神经干细胞-神经元及神经胶质细胞转化过程,研究关键基因与信号通路间动态变化的协同调控所发生的细胞命运转换、细胞形态以及细胞迁移之间的关系,揭示神经细胞分化和迁移的调控机制;3.研究神经元转分化,为移植细胞治疗脑疾病治疗提供可能的细胞来源。以上发现将有助于阐明脑发育机制及疾病致病机理,为相关疾病的诊治提供潜在靶点,为转化研究奠定理论基础。
近期论文
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LiY,JiaoJ*.DeficiencyofTRPM2leadstoembryonicneurogenesisdefectsinhyperthermia.ScienceAdvances.20206:eaay6350.
LiZ,LiY,JiaoJ*.NeuralprogenitorcellsmediatedbyH2A.Z.2regulatemicroglialdevelopmentviaCxcl14intheembryonicbrain.ProcNatlAcadSciUSA.2019116:24122-24132.
XiaW,SuL,JiaoJ*.Cold-inducedproteinRBM3orchestratesneurogenesisviamodulatingYapmRNAstabilityduringcoldstress.JCellBiol.2018217:3464-3479.
SuL,XiaW,ShenT,LiangQ,WangW,LiH,JiaoJ*.H2A.Z.1crosstalkwithH3K56-acetylationcontrolsgliogenesisthroughthetranscriptionoffolatereceptor.NucleicAcidsRes.201846:8817-8831.
LeiX,JiaoJ*.UTXaffectsneuralstemcellproliferationanddifferentiationthroughPTENsignaling.StemCellReports.201810:1193-1207.
QiaoH,LiY,FengC,DuoS,JiF,JiaoJ*.Nap1l1controlsembryonicneuralprogenitorcellproliferationanddifferentiationinthedevelopingbrain.CellRep.201822:2279-2293.
ShenT,JiF,WangY,LeiX,ZhangD,JiaoJ*.Brain-specificdeletionofhistonevariantH2A.zresultsincorticalneurogenesisdefectsandneurodevelopmentaldisorder.NucleicAcidsRes.201846:2290-2307.
LiangQ,XiaW,LiW,JiaoJ*.RNF20controlsastrocyticdifferentiationthroughepigeneticregulationofSTAT3inthedevelopingbrain.CellDeathDiffer.201825:294-306.
LiY,JiaoJ*.HistonechaperoneHIRAregulatesneuralprogenitorcellproliferationandneurogenesisviaβ-catenin.JCellBiol.2017216:1975-1992.
XiaW,JiaoJ*.HistonevariantH3.3orchestratesneuralstemcelldifferentiationinthedevelopingbrain.CellDeathDiffer.201724:1548-1563.
JiF,ShenT,ZouW,JiaoJ*.UCP2regulatesembryonicneurogenesisviaROS-MediatedYapalternationinthedevelopingneocortex.StemCells.201735:1479-1492.
YanL,LiY,ShiZ,LuX,MaJ,HuB,JiaoJ*,WangH*.ThezincfingerE-box-bindinghomeobox1(Zeb1)promotestheconversionofmousefibroblastsintofunctionalneurons.JBiolChem.2017292:12959-12970.
ZhangJ,ChenS,ZhangD,ShiZ,LiH,ZhaoT,HuB,ZhouQ,JiaoJ*.Tet3-MediatedDNAdemethylationcontributestothedirectconversionoffibroblasttofunctionalneuron.CellRep.201617:2326–2339.
WangS,LiangQ,QiaoH,LiH,ShenT,JiF,JiaoJ*.DISC1regulatesastrogenesisintheembryonicbrainviamodulationofRAS/MEK/ERKsignalingthroughRASSF7.Development.2016143:2732-2740.
JiangH,LvX,LeiX,YangY,YangX,JiaoJ*.ImmuneregulatorMCPIP1modulatesTETexpressionduringearlyneocorticaldevelopment.StemCellReports.20167:439-453.
ShiZ,ZhangJ,ChenS,LiY,LeiX,QiaoH,ZhuQ,HuB,ZhouQ,JiaoJ*.ConversionofFibroblaststoParvalbuminNeuronsbyOneTranscriptionFactor,Ascl1,andtheChemicalCompoundForskolin.JBiolChem.2016291:13560-13570.
ShenT,JiF,YuanZ,JiaoJ*.CHD2isrequiredforembryonicneurogenesisinthedevelopingcerebralcortex.StemCells.201533:1794-1806.
XiaW,LiuY,JiaoJ*.GRM7regulatesembryonicneurogenesisviaCREBandYAP.StemCellReports.20154:795-810.
LvX,JiangH,LiuY,LeiX,JiaoJ*.MicroRNA-15bpromotesneurogenesisandinhibitsneuralprogenitorproliferationbydirectlyrepressingTET3duringearlyneocorticaldevelopment.EMBORep.201415:1305-1314.
WangS,LiB,QiaoH,LvX,LiangQ,ShiZ,XiaW,JiF,JiaoJ*.Autophagy-relatedgeneAtg5isessentialforastrocytedifferentiationinthedevelopingmousecortex.EMBORep.201415:1053-1061.
ZhangJ,JiF,LiuY,LeiX,LiH,JiG,YuanZ,JiaoJ*.Ezh2regulatesadulthippocampalneurogenesisandmemory.JNeurosci.201434:5184-5199.
HuangW,SheL,ChangX,YangR,WangL,JiH,JiaoJ,PooM.ProteinkinaseLKB1regulatespolarizeddendriteformationofadulthippocampalnewbornneurons.ProcNatlAcadSciUSA.2014111:469-474.
ShiZ,ShenT,LiuY,HuangY,JiaoJ*.Retinoicacidreceptorgamma(Rarg)andnuclearreceptorsubfamily5,groupA,member2(Nr5a2)promoteconversionoffibroblaststofunctionalneurons.JBiolChem.2014289:6415-6428.
LvX,JiangH,LiB,LiangQ,WangS,ZhaoQ,JiaoJ*.ThecrucialroleofAtg5incorticalneurogenesisduringearlybraindevelopment.SciRep.20144:6010.
MengF,ChenS,MiaoQ,ZhouK,LaoQ,ZhangX,GuoW,JiaoJ*.Inductionoffibroblaststoneuronsthroughadenoviralgenedelivery.CellRes.201222:436-440.
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JiaoJ,ChenDF.Inductionofneurogenesisinnon-conventionalneurogenicregionsoftheadultCNSbynicheastrocyte-producedsignals,StemCells.200826:1221-1230.
JiaoJ,HuangX,Feit-LeithmanRA,NeveRL,SniderW,DarttDA,ChenDF.Bcl-2enhancesCa2+signalingtosupporttheintrinsicregenerativecapacityofCNSaxons.EMBOJ.200524:1068-1078.