刘峰 - 中国科学院大学 - 生命科学学院

个人简介

刘峰，男，博士，中国科学院动物研究所研究员，博士生导师，“国家杰出青年科学基金”获得者（2014年）、中华人民共和国科学技术部“中青年科技创新领军人才”（2015年）、中华人民共和国国务院“政府特殊津贴”获得者（2016年），“谈家桢生命科学创新奖”获得者（2018年）。2009年在膜生物学国家重点实验室建立血液和心血管发育实验室。1999年在中国科学院遗传所获分子遗传学博士学位。2000-2002在新加坡分子农业生物学研究院（现IMCB）做博士后，开始利用斑马鱼模型从事造血系统的发育生物学研究；2003-2005在美国Vanderbilt 大学医学院从事斑马鱼血管生物学研究；2006-2008在英国牛津大学分子医学研究所（WIMM）利用斑马鱼和非洲爪蟾从事造血干细胞的基础研究。刘峰博士首次建立了斑马鱼cDNA芯片并成功应用于筛选早期发育特异性的基因；其中Lysozyme C已成为斑马鱼髓系细胞最常用的分子标记之一；在牛津大学的工作集中在斑马鱼造血干细胞的起源、心血管发育和分子调控网络的研究，系统阐明了斑马鱼基因组中整个ETS转录因子家族、各个成员的时空表达图谱，并进一步发现Fli1是调控血液和内皮细胞发育分化的主控基因，并和Erg协同调节血管生成（Angiogenesis），Etsrp既调控内皮细胞分化又控制髓细胞的发育。

近期论文

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53. Gao SW and Liu F*. Fetal liver: an ideal niche for hematopoietic stem cell expansion. Sci China Life Sci. 2018, 61(8):885-92 52. Zhang YF, Gao S, Xia J, Liu F*. Hematopoietic Hierarchy - An Updated Roadmap. Trends Cell Biol. 2018, 28(12):976-86 51. Lv JH, Zhang YF, Gao SW, Zhang CX, Chen YS, Li W, Yang YG, Zhou Q, Liu F*. Endothelial-specific m6A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling. Cell Res. 2018, 28(2):249-52 50. Zhang CX and Liu F*. RNA methylation regulates hematopoietic stem/progenitor cell specification. Sci China Life Sci. 2018, 61(5):610-2 49. Yan HW, Zhang CX, Wang ZQ, Tu T, Duan HX, Luo YT, Feng J, Liu F*, Yan X*. CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis. Sci Rep. 2017, 7(1):7442 48. Shang YL, Zhu FX, Wang LN, Ouyang YC, Dong MZ, Liu C, Zhao HC, Cui XH, Ma DY, Zhang ZG, Yang XY, Guo YS, Liu F, Yuan L, Gao F*, Guo XJ*, Sun QY*, Cao YX*, Li W*. Essential role for SUN5 in anchoring sperm head to the tail. Elife. e28199 47. Zhang Y, Xue YY, Cao CW, Huang JJ, Hong QL, Hai T, Jia QT, Wang XL, Qin GS, Yao J, Wang X, Zheng QT, Zhang R, Li YS, Luo AL, Zhang N, Shi GZ, Wang YF, Ying H, Liu ZH, Wang HM, Meng AM, Zhou Q, Wei H*, Liu F*, Zhao J*. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017, 130(20):2161-70 46. Wang L, Liu ZB, Lin H, Ma DY, Tao QH, Liu F*. Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 2017, 36(20):2987-97. [Link] 45. Zhang CX, Chen YS, Sun BF, Wang L, Yang Y, Ma DY, Lv JH, Heng J, Ding YY, Xue YY, Lu XY, Xiao W, Yang YG*, Liu F*. m6A modulates haematopoietic stem and progenitor cell specification. Nature. 2017, 549(7671):273-76. [Link] 44. Xue YY, Lv JH, Zhang CX, Wang L, Ma DY, Liu F*. The vascular niche regulates hematopoietic stem and progenitor cell lodgment and expansion via klf6a-ccl25b. Dev Cell. 42(4):349-362(2017) [link] 43. Lv JH, Liu F*. Application of aorta-gonad-mesonephros explant culture system in developmental hematopoiesis. JoVE (2017) [Link] 42. Lv JH, Liu F*. The role of serotonin beyond the central nervous system during embryogenesis. Front Cell Neurosci. 11:74 (2017) [Link] 41. He QP, Gao SW, Lv JH, Li W, Liu F*. BLOS2 maintains hematopoietic stem cells in the fetal liver via repressing Notch signaling. Exp Hematol. 51:1-6.e2 (2017) [link] 40. Lv JH, Wang L, Gao Y, Ding YQ, Liu F*. 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 214(2):529-545(2017) [link] 39. Liu TH, Tang YJ, Huang Y, Wang L, Guo XL, Mi JQ, Liu LG, Zhu H, Zhang Y, Chen L, Liu X, Zhang LH, Ye QJ, Li BS, Tang JY, Ford A, Enver T, Liu F*, Chen GQ*, Hong DL*. Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin. Leukemia. 31(5):1079-1086(2017) [link] 38. Ma DY, Xue YY, Zhang YF, Sun YH, Meng AM, Liu F*. The rising zebrafish research in China: Meeting report of the 3rd Chinese Zebrafish Principal Investigator Meeting & the Inaugural Meeting of China Zebrafish Society. J Genet Genomics, 43(10):617-620, (2016) 37. Zhou WW, He QP, Zhang CX, He Xin, Cui ZB, Liu F*, Li W*. BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. Elife. e18108, (2016) 36. Wei YL, Xu J, Zhang WQ, Wen ZL, Liu F*. RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development. 2016 May 5. pii: dev.126797. [Epub ahead of print]