周光飚 - 中国科学院动物研究所 -

个人简介

周光飚，博士，中国科学院动物研究所二级研究员，膜生物学国家重点实验室肿瘤分子机理与靶向疗法研究组组长，中国科学院大学岗位教授，中国科学技术大学兼职博导，国家杰出青年科学基金获得者。FrontiersofMedicine杂志执行副主编，AustinJournalofLungCancerResearch、InternationalJournalofHematologyResearch、AustinPathology杂志编委，中国抗癌协会肿瘤转移专业委员会委员、中国转化医学联盟第一届理事会理事、中国病理生理学会实验血液学专业委员会第7届委员，美国癌症研究学会会员、美国血液学会会员。主要研究空气污染、吸烟引起肺癌的机理及中药抗肿瘤药理，在Elife、EBioMedicine、PNAS、Blood、Oncotarget、Carcinogenesis、ScienceTranslationalMedicine、Science等杂志发表论文70篇，参编专著4部，参译书籍1部，12项专利获得授权。JProtRes、Oncotarget、MolCancer、IntJCancer、TobaccoInducedDiseases、LungCancer等杂志特约审稿人，被评为CancerLetters杂志的Outstandingreviewer。已毕业研究生16人，目前实验室有在读研究生11人（硕士生4人，博士生7人）。迄今课题组已有1人获中国科学技术大学研究生国家奖学金，2人获中国科学院朱李月华优秀博士生奖，2人获地奥奖学金，1人获中国科学院大学生奖学金，1人被评为中科院研究生院优秀学生干部，1名被评为三好学生，2名被评为优秀党员。科研工作经历： 2009-现在研究员，中国科学院动物研究所生物膜与膜工程国家重点实验室 2007-现在博导，中国科学技术大学 2005-2009研究员，中科院广州生物医药与健康研究院 2003-2005博士后，中国科学院上海生命科学研究院 1993-1997医师，广西桂林铁路医院主要学历： 2000-2003博士研究生，上海交通大学医学院，专业方向：内科学 1997-2000硕士研究生，中南大学湘雅医学院，专业方向：内科学 1988-1993学士，广西医科大学，专业方向：临床医学获奖及荣誉：曾获中国科学院王宽诚博士后工作奖励金、中国博士后科学基金，被评为中国科学院广州生物医药与健康研究院先进共产党员、先进工作者、中国科学院广州教育基地优秀研究生导师、中国科学院广州分院优秀共产党员、广东省省直机关优秀共产党员。承担科研项目情况：国家杰出青年科学基金（2015-2019）：中药抗肿瘤药理；国家科技部资助“973”项目（2012-2016）：炎症诱导肿瘤的分子调控网络研究，课题骨干；国家自然科学基金（2012-2015）：环境致癌物苯并芘灭活PTEN的机制研究；项目负责人；国家自然科学基金（2011-2013）：CIP2A与肺癌发生及作为治疗新靶点的实验研究；项目负责人；国家科技部资助“973”项目（2010-2014）：基于系统生物医学基础的白血病临床转化研究，分课题负责人；

研究领域

研究领域：肺癌发病机理（Molecularpathogenesisofnon-smallcelllungcancer）；中药抗肿瘤药理（mechanismsofactionofTraditionalChineseMedicineintreatingcancer）。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

WangGZ,ChengX,ZhouB,WenZS,HuangYC,ChenHB,LiGF,HuangZL,ZhouYC,FengL,WeiMM,QuLW,CaoY,ZhouGB.ThechemokineCXCL13inlungcancersassociatedwithenvironmentalpolycyclicaromatichydrocarbonspollution,eLIFE,2015;4:e09419. LiuYQ,WangXL,ChengX,LuYZ,WangGZ,LiXC,ZhangJ,WenZS,HuangZL,GaoQL,YangLN,ChengYX,TaoSC,LiuJ,ZhouGB.Skp1inlungcancer:Clinicalsignificanceandtherapeuticefficacyofitssmallmoleculeinhibitors.Oncotarget,2015;6:34953-34967 WangGZ,ChengX,LiXC,LiuYQ,WangXQ,ShiX,WangZY,GuoYQ,WenZS,HuangYC,ZhouGB.TobaccosmokeinducesproductionofchemokineCCL20topromotelungcancer.CancerLetters,2015;363:60-70 PanHL,WenZS,HuangYC,ChengX,WangGZ,ZhouYC,WangZY,GuoYQ,CaoY,ZhouGB.Down-regulationofmicroRNA-144inairpollution-relatedlungcancer.SciRep,2015;5:14331. WangGZ,LiuYQ,ChengX,ZhouGB.CelastrolinducesproteasomaldegradationofFANCD2tosensitizelungcancercellstoDNAcrosslinkingagents.CancerScience,2015;106(7):902-908 YuXJ,YangMJ,ZhouB,WangGZ,HuangYC,WuLC,ChengX,WenZS,HuangJY,ZhangYD,GaoXH,LiGF,HeSW,GuZH,MaL,PanCM,WangP,ChenHB,HongZP,WangXL,MaoWJ,JinXL,KangH,ChenST,ZhuYQ,GuWY,LiuZ,DongH,TianLW,ChenSJ,CaoY,WangSY,ZhouGB.CharacterizationofSomaticMutationsinAirPollution-RelatedLungCancer,EBioMedicine,2015;2:583-590. LiJ,ZhongHY,ZhangY,XiaoL,BaiLH,LiuSF,ZhouGB,ZhangGS.GTF2I-RARAisanovelfusiontranscriptinat(7;17)variantofacutepromyelocyticleukaemiawithclinicalresistancetoretinoicacid.BrJHaematol,2015;168:904-908. MiJQ,ChenSJ,ZhouGB,YanXJ,ChenZ.Synergistictargetedtherapyforacutepromyelocyticleukaemia:amodeloftranslationalresearchinhumancancer.JInternMed,2015;278:627-42. MandelJH,WendtC,LoC,ZhouG,HertzM,RamachandranG.AmbientairpollutionandlungdiseaseinChina:healtheffects,studydesignapproachesandfutureresearch.FrontMed,2015;9:392-400. LiuZ,MaL,WenZS,HuZ,WuFQ,LiW,LiuJ,ZhouGB.CancerousinhibitorofPP2A(CIP2A)istargetedbynaturalcompoundcelastrolfordegradationinnon-small-celllungcancer.Carcinogenesis,2014;35:905-914. LiuZ,MaL,WenZS,ChengYX,ZhouGB*.EthoxysanguinarineInducesInhibitoryEffectsandDownregulatesCIP2AinLungCancerCells.ACSMedChemLett,2014;5:113-118. LiuY,XiaoQ,LiuY,LiZ,QiuY,ZhouG,YaoZ,JiangS.Biologicalevaluationofnewmimeticsofannonaceousacetogenins:Alterationofrightscaffoldbyclicklinkagewitharomaticfunctionalities.EurJMedChem,2014;78:248–258. LiuY,LiuY,LiZ,ZhouGB,YaoZJ,JiangS.Identificationofnovelbivalentmimeticsofannonaceousacetogeninsviaascaffold-hoppingstrategy.BioorgMedChemLett2014;24:1650-1653. ZhouG,ChenZ.TranslatingthepowerofTCMintopatients'hope.FrontMed2014;8:265-267 WuLC,WenZS,QiuYT,ChenXQ,ChenHB,WeiMM,LiuZ,JiangS,ZhouGB.LargazoleArrestsCellCycleatG1PhaseandTriggersProteasomalDegradationofE2F1inLungCancerCells.ACSMedChemLett,2013;4:921-926. LiuJL,ZengGZ,LiuXL,LiuYQ,HuZG,LiuY,TanNH,ZhouGB.SmallcompoundbigelovinexertsinhibitoryeffectsandtriggersproteolysisofE2F1inmultiplemyelomacells.CancerSci,2013;104:1697-1704. LiuY,CaoW,ZhangB,LiuYQ,WangZY,WuYP,YuXJ,ZhangXD,MingPH,ZhouGB,HuangL..Thenaturalcompoundmagnololinhibitsinvasionandexhibitspotentialinhumanbreastcancertherapy.SciRep,2013;3:3098. ZhangB,JiaoJ,LiuY,GuoLX,ZhouB,LiGQ,YaoZJ,ZhouGB.GefitinibanalogueV1801inducesapoptosisofT790MEGFR-harboringlungcancercellsbyup-regulationoftheBH-3onlyproteinNoxa.PLoSONE,2012;7:e47049. YuXJ,HanQB,WenZS,MaL,GaoJ,ZhouGB.GambogenicacidinducesG1arrestviaGSK3β-dependentCyclinD1degradationandtriggersautophagyinlungcancercells.CancerLett,2012;322:185-194. FangHT,ZhangB,PanXF,GaoL,ZhenT,ZhaoHX,MaL,XieJ,LiuZ,YuXJ,ChengX,FengTT,ZhangFX,YangY,HuZG,ShengGQ,ChenYL,ChenSJ,ChenZ,ZhouGB.BortezomibinterfereswithC-KITprocessingandtransformsthet(8;21)-generatedfusionproteinsintotumor-suppressingfragmentsinleukemiacells.ProcNatlAcadSciUSA,2012;109:2521-2526. LiuYQ,ChengX,GuoLX,MaoC,ChenYJ,LiuHX,XiaoQC,JiangS,YaoZJ,ZhouGB.Identificationofanannonaceousacetogeninmimetic,AA005,asanAMPKactivatorandautophagyinducerincoloncancercells.PLoSONE,2012;7:e47049. ZhenT,WuCF,LiuP,WuHY,ZhouGB,LuY,LiuJX,LiangY,LiKK,WangYY,XieYY,HeMM,CaoHM,ZhangWN,ChenLM,PetrieK,ChenSJ,andChenZ.TargetingofAML1-ETOint(8;21)leukemiabyoridoningeneratesatumorsuppressor-likeprotein.SciTranslMed,2012;4:127ra38. QuanJ,JohnsonN,ZhouG,ParsonsP,BoyleG,GaoJ.Potentialmoleculartargetsforinhibitingboneinvasionbyoralsquamouscellcarcinoma:areviewofmechanisms.CancerandMetastasisReviews,2012;31:209-219. LiuJX,ZhouGB,ChenSJ,ChenZ.Arseniccompounds:revivedancientremediesinthefightagainsthumanmalignancies.CurrentOpinioninChemicalBiology,2012;16:92-98. ChenSJ,ZhouGB.Targetedtherapy:Thenewleaseonlifeforacutepromyelocyticleukemia,andbeyond.IUBMBLife.2012;64:671-675. XiaoY,ShaoY,YuX,ZhouG.TheepidemicstatusandriskfactorsoflungcancerinXuanweiCity,YunnanProvince,China.FrontMed,2012;6:388-94. MaL,WenZS,HuZ,LiuZ,MaJ,ChenXQ,LiuYQ,PuJX,XiaoWL,SunHD,ZhouGB.Overexpressionandsmallmolecule-triggereddownregulationofCIP2Ainlungcancer.PLoSONE,2011;6:e20159. LiuZ,MaL,ZhouGB.ThemainanticancerbulletsoftheChinesemedicinalherb,thundergodvine.Molecules,2011;16:5283-5297. LiuY,ChenXQ,LiangHX,ZhangFX,ZhangB,JinJ,ChenYL,ChengYX,ZhouGB.Smallcompound6-O-angeloylplenolininducesmitoticarrestandexhibitstherapeuticpotentialsinmultiplemyeloma.PLoSONE,2011;6:e21930. ZhouGS,HuZ,FangHT,ZhangFX,PanXF,ChenXQ,HuAM,XuL,ZhouGB.Biologicactivityoftriptolideint(8;21)acutemyeloidleukemiacells.LeukRes,2011;35:214-218. ChenSJ,ZhouGB,ZhangXW,MaoJH,deTheH,ChenZ.Fromanoldremedytoamagicbullet:molecularmechanismsunderlyingthetherapeuticeffectsofarsenicinfightingleukemia.Blood,2011;117:6425-6437. ChenZ,ZhouG.TranslationalmedicineshouldtranslatemedicalscienceandtechnologyintohealthcareforeveryoneinChina.ScienceChinaLifeScience,2011;54:1074-1076. XiaoQ,LiuY,QiuY,YaoZ,ZhouG,YaoZJ,JiangS.Design,synthesisofsymmetricalbivalentmimeticsofannonaceousacetogeninsandtheircytotoxicities.BioorganMedChemLett,2011;21:3613-3615. WuW,LiZ,ZhouG,JiangS.TotalsynthesisofargyrinsAandE.TetrahedronLetters2011;52:2488-2491. ZengX,YinBL,HuZ,LiaoCZ,LiuJL,LiS,LiZ,NicklausMC,ZhouGB,JiangS.Totalsynthesisandbiologicalevaluationoflargazoleandderivativeswithpromisingselectivityforcancerscells.OrgLett,2010;12:1368-1371. ZhangXW,YanXJ,ZhouZR,YangFF,WuZY,SunHB,LiangWX,SongAX,Lallemand-BreitenbachV,JeanneM,ZhangQY,YangHY,HuangQH,ZhouGB,TongJH,ZhangY,WuJH,HuHY,deThéH,ChenSJ,ChenZ.ArsenictrioxidecontrolsthefateofthePML-RARalphaoncoproteinbydirectlybindingPML.Science,2010;328:240-243. XiaoQ,LiuY,QiuY,ZhouG,MaoC,LiZ,YaoZJ,JiangS.PotentAntitumorMimeticsofAnnonaceousAcetogeninsEmbeddedwithanAromaticMoietyintheLeftHydrocarbonChainPart.JMedChem,2010;54:525-533. ChenSJ,ChenXP,ZhouGB.Healthypeople,healthyjournal.FrontiersofMedicineinChina,2010;4:1-2. HuZ,PanXF,WuFQ,MaLY,LiuDP,LiuY,FengTT,MengFY,LiuXL,JiangQL,ChenXQ,LiuJL,LiuP,ChenZ,ChenSJ,ZhouGB.Synergybetweenproteasomeinhibitorsandimatinibmesylateinchronicmyeloidleukemia.PLoSONE.2009;4:e6257. DingLF,LiuY,LiangHX,LiuDP,ZhouGB,ChengYX.TwonewterpeneglucosidesandantitumoragentsfromCentipedaminima.JournalofAsianNaturalProductsResearch,2009;11:732-736. ZengGZ,TanNH,JiCJ,FanJT,HuangHQ,HanHJ,ZhouGB.ApoptosisinducementofbigelovinfromInulahelianthus-aquaticaonhumanleukemiaU937cells.PhytotherRes,2009;23:885-891. HuJ,LiuYF,WuQF,XuF,ShenZX,ZhuYM,LiJM,TangW,ZhaoWL,WuW,SunHP,ChenQS,ChenB,ZhouGB,ZelentA,WaxmanS,WangZY,ChenSJ,ChenZ.Long-termefficacyandsafetyofall-transretinoicacid/arsenictrioxidebasedtherapyinnewlydiagnosedacutepromyelocyticleukemia.ProcNatlAcadSciUSA,2009;106:3342-3347. 方海同,胡政,周光飚.一种基于绿色荧光蛋白的蛋白酶体抑制剂细胞筛选模型.生物工程学报,2009;25:452-456. 冯婷婷,普建新,胡政,刘大鹏,孙汉董,周光飚.二萜化合物RabdocoetsinB抑制蛋白酶体功能并诱导t(8;21)白血病细胞凋亡.生物工程学报,2009;25:1218-1224. WangL,ZhouGB,LiuP,SongJH,LiangY,YanXJ,XuF,WangBS,MaoJH,ShenZX,ChenSJ,ChenZ.DissectionofmechanismsofChinesemedicinalformulaRealgar-Indigonaturalisasaneffectivetreatmentforpromyelocyticleukemia.ProcNatlAcadSciUSA,2008;105:4826-4831. 陈竺,陈赛娟,周光飚.实验血液学架起实验室与临床的桥梁－血液学的希望.中国实验血液学杂志,2008;16:1-21. ChenSJ,ZhouGB,BaiXT,ChenZ.Nucleoporin.In:SchwabM,ed.EncyclopediaofCancer:SpringerBerlinHeidelberg;2008:2124-2126. ShenY,XuQ,HanZ,LiuH,ZhouGB.Analysisofphenotype-genotypeconnection:thestoryofdissectingdiseasepathogenesisingenomicerainChina,andbeyond.PhilosTransRSocLondBBiolSci,2007;362:1043-1061. ZhouGB,KangH,WangL,GaoL,LiuP,XieJ,ZhangFX,WengXQ,ShenZX,ChenJ,GuLJ,YanM,ZhangDE,ChenSJ,WangZY,ChenZ.Oridonin,aditerpenoidextractedfrommedicinalherbs,targetsAML1-ETOfusionproteinandshowspotentantitumoractivitywithlowadverseeffectsont(8;21)leukemiainvitroandinvivo.Blood,2007;109:3441-3450. ZhouG,ZhangJ,WangZ,ChenS,ChenZ.Treatmentofacutepromyelocyticleukaemiawithall-transretinoicacidandarsenictrioxide:aparadigmofsynergisticmoleculartargetingtherapy.PhilTransRSocB,2007;362:959-971. ZhouGB,LiG,ChenSJ,ChenZ.Fromdissectionofdiseasepathogenesistoelucidationofmechanismsoftargetedtherapies:leukemiaresearchinthegenomicera.ActaPharmacolSin2007;28:1434-1449. ZhouGB,ChenSJ,WangZY,ChenZ.Backtothefutureoforidonin:again,compoundfrommedicinalherbshowspotentantileukemiaefficaciesinvitroandinvivo.CellRes,2007;17:274-276. HuJ,ZhouGB,WangZY,ChenSJ,ChenZ.Mutanttranscriptionfactorsandtyrosinekinasesastherapeutictargetsforleukemias:fromacutepromyelocyticleukemiatochronicmyeloidleukemiaandbeyond.AdvCancerRes,2007;98:191-220. WangL,ZhaoWL,YanJS,LiuP,SunHP,ZhouGB,WengZY,WuWL,WengXQ,SunXJ,ChenZ,SunHD,ChenSJ.EriocalyxinBinducesapoptosisoft(8;21)leukemiacellsthroughNF-kappaBandMAPKsignalingpathwaysandtriggersdegradationofAML1-ETOoncoproteininacaspase-3-dependentmanner.CellDeathDiffer,2007;14:306-317. 扶云碧，孙启鑫，孟凡义，谢军，周光飚.蛋白酶体抑制剂硼替佐米诱导髓系白血病细胞株HL60凋亡的机制研究.中华医学杂志,2006;86:2413-2416. WangYY,ZhouGB,YinT,ChenB,ShiJY,LiangWX,JinXL,YouJH,YangG,ShenZX,ChenJ,XiongSM,ChenGQ,XuF,LiuYW,ChenZ,ChenSJ..AML1-ETOandC-KITmutation/overexpressionint(8;21)leukemia:ImplicationinstepwiseleukemogenesisandresponsetoGleevec.ProcNatlAcadSciUSA,2005;102:1104-1109. ZhouGB,ZhaoWL,WangZY,ChenSJ,ChenZ.Retinoicacidandarsenicfortreatingacutepromyelocyticleukemia.PLoSMedicine,2005;2:33-38. ZhouGB,ZhaoWL,WangZY,ChenSJ,ChenZ.Retinoicacidandarsenicfortreatingacutepromyelocyticleukemia.PLoSMedicine,2005;2:33-38. 陈丽娟，董颖，陈思宇，张龙，周光飚，陈冰，王龙，陈竺，陈赛娟.PLZF-RARα/RARα-PLZF双阳性转基因小鼠发生白血病模型研究.中国实验血液学杂志,2005;13:924-931. ZhangGS,ZhouGB,DaiCW.Upregulationandactivationofcaspase-3orcaspase-8andelevationofintracellularfreecalciummediatedapoptosisofindomethacin-inducedK562cells.ChinMedJ(Engl),2004;117:978-984. 周光飚,董颖，王月英，印彤，亢卉，陈竺，陈赛娟.白血病致病基因产物靶向治疗：从急性早幼粒到其他类型白血病.中国科学（C辑）.2004,34:487-500. 董颖,陈丽娟,陈思宇,张龙,周光飚,王龙,陈赛娟.hCG/RARα/PLZF转基因小鼠发生髓系增殖性疾病.中华血液学杂志,2004,25:745-747. 周光飚.对八纲辨证发展的思考.中国中西医结合杂志,2002;22:233－234. 周光飚,王振义.诱导分化治疗急性白血病的研究进展.中华血液学杂志,2002;23(1):49-51. 周光飚,张广森.吲哚美辛诱导K562细胞凋亡过程中半胱天冬酶及细胞内游离钙浓度的变化.中华血液学杂志,2001;21:241-244. ZhangG,TuC,ZhangG,ZhouG,ZhengW.Indomethacininducesapoptosisandinhibitsproliferationinchronicmyeloidleukemiacells.LeukRes2000;24:385-392. 周光飚.Caspase家族与细胞凋亡调控.国外医学分子生物学分册,2000;22:167-170. 周光飚.Caspase家族在恶性血液病的表达及意义研究进展.国外医学输血及血液学分册,1999;22:394-396. 周光飚.肿瘤具有两面性吗.医学与哲学,1999;20:19-20. 周光飚.端粒-端粒酶系统与血液系统恶性肿瘤.国外医学输血及血液学分册,1998;21:406-410. 周光飚.弓形虫病1例.临床荟萃,1996;11:192. 周光飚.炸药外洗致溶血1例.中国实用内科杂志,1996;16:554.

学术兼职

FrontiersofMedicine杂志执行副主编中国抗癌协会肿瘤转移专业委员会委员中国病理生理学会实验血液学专业委员会第7届委员中国转化医学联盟第一届理事会理事 AustinJournalofLungCancerResearch编委 InternationalJournalofHematologyResearch编委 AustinPathology编委美国癌症研究学会会员美国血液学会会员