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个人简介

1997-2002,北京大学医学部,药理学学士 2002-2007,中国科学院生物物理研究所,理学博士 2007-2009,美国斯科利普斯(Scripps)研究所 Research associate 2009-2012,美国索尔克(Salk)生物学研究所 Research associate 2012-至今,中科院生物物理研究所,研究员,博士生导师 2014-至今,中国科学院大学,岗位教授

研究领域

1. 基于干细胞的人类疾病研究和精准治疗 2. 人类衰老的遗传和表观遗传信息解码 3. 新型基因组编辑和成像技术的发展和应用

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J#, Tang F#, Liu GH#. FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell. 2019. 24(3), 447-461 (cover story)(#Corresponding author) 2. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J,Wang S, Belmonte JC, Chan P, Qu J#, Tang F#, Liu GH#.Upregulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology. 2019. 17(4):e3000201 (#Corresponding author) 3. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J#, Tang F#, Liu GH#. Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis. Cell Reports. 2019. 26(13):3643-3656.(#Corresponding author) 4. Ling C, Liu Z, Song M, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Belmonte JC, Wang Z, Qu J#, Yuan Y#, Liu GH#. Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. Protein Cell. 2019.10(4):249-271 (#Corresponding author) 5. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W#, Liu GH#, Hu B#. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018. 560(7720):661-665. (#Corresponding author) 6. Zhang W, Song M, Qu J#, Liu GH#. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circ Res. 2018. 123:773-786. (#Corresponding author) 7. Geng L, Liu Z, Zhang W#, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M#, Qu J#, Liu GH#. Chemical Screen Identifies a GeroprotectiveRole of Quercetin in Premature Aging. Protein Cell. 2018. doi: 10.1007/s13238-018-0567-y. (#Corresponding author) 8. Wang S,Hu B,Ding Z,Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J#, Tang F#, Liu GH#. ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. Cell Discovery. 2018. Jan 5;4:2. (#Corresponding author) 9. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J#, Suzuki K#, Belmonte JC#, Liu GH#. Differential stem cell aging kinetics inHutchinson–Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018. 9(4):333-350.(#Corresponding author) 10. Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH#, Wang L#. Metformin alleviates human cellular aging by upregulating the ER peroxidase GPx7. Aging Cell. 2018. 16:e12765.(#Corresponding author) 11. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T#, Qu J#, Liu GH#. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Res. 2017. 27(4):483-504. (#Corresponding author) 12. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J#, Tang F#, Liu GH#. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Res. 2017. doi:10.1038/cr.2017 (#Corresponding author) 13. Ren R, Ocampo A, Liu GH#, Belmonte JC#. Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell Metab. 2017. j.cmet.2017.07.019 (#Corresponding author)   14. Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y#, Qu J#, Liu GH#. CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosispatient iPSCs. Protein Cell. 2017. DOI 10.1007/s13238-017-0397-3.(#Corresponding author) 15. Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH#, Misteli T#, Repression of the antioxidant NRF2 pathway in premature aging. Cell. 2016. 165(6):1361-74 (#Corresponding author) 16. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J#, Tang F#, Liu GH#. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016. 26(2):190-205. (#Corresponding author) 17. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nu?ez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature. 2016. 540(7631):144-149. 18. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z.SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495-507 19. Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JC#, Qu J#, Liu GH#. Modeling Xeroderma Pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein Cell. 2016. 7(3):210-21. (#Corresponding author) 20. Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z, Deng H, Ye Y, Ren R, Wang Y, Li J, Qiao J, Qu J#, Zhang W#, Liu GH#. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016. 7(7):478-88. (#Corresponding author)

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