Dabrowiak, James - Syracuse University - Department of Chemistry

个人简介

American Cancer Society Scholar, 1985 Faculty Advisor Award, International Precious Metals Institute, 2012 Henry J. Albert Award, BASF Corporation, 2014

研究领域

Bioinorganic chemistry; metallo-pharmaceutical chemistry

近期论文

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“Activation of carboplatin by carbonate” Di Pasqua, A. J., Goodisman, J., Kerwood, D. J., Toms, B. B., Dubowy, R. L., Dabrowiak, J. C. Chem. Res. Toxicol. 19, 139-49 (2006). “Modification and uptake of a cisplatin carbonato complex by Jurkat cells” Centerwall, C. R., Tacka, K. A., Kerwood, D. J., Goodisman, J., Toms, B. B., Dubowy, R. L., Dabrowiak, J. C. Mol. Pharmacol. 70, 348-55 (2006). “Role of carbonate in the cytotoxicity of carboplatin” Di Pasqua, A. J., Goodisman, J., Kerwood, D. J., Toms, B. B. Dubowy, R. L., Dabrowiak, J. C. Chem. Res. Toxicol. 20, 896-904 (2007). “The activation of platinum (II) antiproliferative drugs in carbonate medium evaluated by means of a DNA-biosensor” Ravera, M., Bagni, G., Mascini, M., Dabrowiak, J. C., Osella, D., J. Inorg Biochem. 101, 1023-1027 (2007). “Modification of carboplatin by Jurkat cells”, Di Pasqua, A. J., Goodisman, J., Kerwood, D. J., Toms, B. B., Dabrowiak, J. C., J. Inorg. Biochem., 101, 1438-1441 (2007). “Cytotoxicity of mesoporous silica nanomaterials” Di Pasqua, A. J., Sharma, K. K., Shi, Y., Toms, B. B., Ouellette, W., Dabrowiak, J. C., and Asefa, T., J. Inorg. Biochem., 102, 1416-23 (2008). “New extracellular resistance mechanism for cisplatin”, Centerwall, C. R., Kerwood, D. J., Goodisman, J. Toms, B. B., and Dabrowiak, J. C., J. Inorg. Biochem., 102, 1044-9 (2008) "Influence of carbonate on the binding of carboplatin to DNA", Sorokanich, R. S., Di Pasqua, A. J., Geier, M., Dabrowiak, J.C., Chem. Biodivers., 5, 1540-44 (2008) “Formation of Carbonato and Hydrogencarbonato Complexes in the Reaction of Platinum Anticancer Drugs with Carbonate” Di Pasqua, A. J., Centerwall, C. R., Kerwood, D. J., Dabrowiak, J. C. Inorg. Chem. 28, 1192-7 (2009). “Preparation of Antibody-Conjugated Gold Nanoparticles” Di Pasqua, A. J., Mishler, R. E., Ship, Y.-L., Dabrowiak, J. C., Asefa, T. Materials Lett., 63, 1876-9 (2009). “Adsorption of the Pt+2 Anticancer Drug Carboplatin by Mesoporous Silica” Di Pasqua, A. J., Wallner, S., Kerwood, D. J., Dabrowiak, J. C. Chem. Biodivers., 6, 1343-9 (2009). Textbook, Dabrowiak, J. C., Metals in Medicine, John-Wiley & Sons, Ltd, Chichester, UK, 2009. “Cytotoxicity of Cu(II) and Zn(II) 2,2′-Bipyridyl Complexes: Dependence of IC50 on Recovery Time”. Shi, Y., Toms, B. B., Dixit, N., Kumari, N., Mishra, L., Goodisman, J., Dabrowiak, J. C. Chem. Res. Toxicol., 2010, 23, 1417-26. “DNA-capped nanoparticles designed for doxorubicin drug delivery” Alexander, C. M., Maye, M. M., Dabrowiak, J. C. Chem. Commun., 2011, 47, 3418-20. “Stability of carboplatin and oxaliplatin in their infusion solutions is due to self-association” Di Pasqua, A. J., Kerwood, D. J., Shi, Y., Goodisman, J., Dabrowiak, J. C. Dalton Trans. 2011, 40, 4821-25. “Adamantane-platinum conjugate hosted in β-cyclodextrin: Enhancing transport and cytotoxicity by noncovalent modification”. Prashar, D., Shi, Y., Bandyopadhyay, D., Dabrowiak, J. C., Luk, Y.-Y. Bioorg. Med. Chem. Lett. 2011, 21, 7421-25. “Pt(IV) complexes as prodrugs for cisplatin”. Shi, Y., Lui, S.-A., Kerwood, D. J., Goodisman, J., Dabrowiak, J. C. J. Inorg. Biochem., 2012, 107, 6-14. “Understanding how the anticancer drug carboplatin works: From the bottle to the cell”. Di Pasqua, A. J., Goodisman, J., Dabrowiak, J. C. Inorg. Chim. Acta., 2012, 389, 29-35. “Enhanced detection of gold nanoparticles in agarose gel electrophoresis”. Hasenoehrl, C., Alexander, C. M., Azzarelli, N. N., Dabrowiak, J. C. Electrophoresis., 2012, 33, 1251-54. Investigation of the Drug Binding Properties and Cytotoxicity of DNA-Capped Nanoparticles Designed as Delivery Vehicles for the Anticancer Agents Doxorubicin and Actinomycin D. Alexander, C. M., Dabrowiak, J. C., Maye, M. M. Bioconjug. Chem., 2012, 23, 2061-70. “Guest-host interactions involving platinum anticancer agents. DNA binding and cytotoxicity of a b-cyclodextrin-adamantane Pt(IV) complex.” Shi, Y., Dabrowiak, J. C. Inorg. Chim. Acta, in press. Special Volume, Inorganica Chimica Acta, Dabrowiak, J. C. (Guest Editor) Metals in Medicine, July 2012.