Chisholm, John - Syracuse University - Department of Chemistry

个人简介

Bristol-Myers Squibb Graduate Fellowship, 1999-2000 National Institute of Health Postdoctoral Fellowship, 2000-2002

研究领域

Organic chemistry, medicinal chemistry, synthesis, catalysis, organometallic chemistry

近期论文

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Fernandes, S.; Brooks, R.; Park, M-Y.; Srivastava, N.; Russo, C.M.; Chisholm, J.D.; Kerr W.G. “SHIP Inhibition Enhances Murine Autologous and Allogeneic Hematolymphoid Cell Transplantation.” EBioMedicine, 2015, In Press. Published online February 21, 2015. DOI: 10.1016/j.ebiom.2015.02.004 Duffy, B.C.; Howard, K.T.; Chisholm, J.D. “Alkylation of Thiols using Trichloroacetimidates under Neutral Conditions.” Tetrahedron Lett., 2015, In Press. Published online December 19, 2014. DOI: 10.1016/j.tetlet.2014.12.042[Invited submission for the Harry H. Wasserman memorial issue, peer reviewed] Corcoran, J.T.; Carberry, P.; Viernes, D.R., Chisholm, J.D. “Intramolecular Diels-Alder Reactions Utilizing Aldehyde and Ketone Dienophiles. A Rare Variant of the Diels-Alder Reaction.” Mini-Rev. Org. Chem., 2015, 2, 149-161. DOI: 10.2174/1570193X11666141029000030 Wallach, D.R.; Stege, P.C.; Shah, J.P.; Chisholm, J.D. “Selective Monoalkylation of Anilines withTrichloroacetimidates.” J. Org. Chem., 2015, 80, 1993-2000. DOI: 10.1021/jo5027222 Brooks, R.; Iyer, S.; Akada, H.; Russo, C.M.; Chisholm, J.D.; Kerr W.G. “Coordinate Expansion of the Hematopoietic and Mesenchymal Stem Cell Compartments by SHIPi.” Stem Cells, 2015, 33, 848-858. DOI: 10.1002/stem.1902[This contribution was featured in the Research Highlights section of Science (Science, 2014, 346,1196) and in Mesenchymal Cell News (volume 6.43, November 18, 2014)] Iyer, S.; Viernes, D.R.; Chisholm, J.D.; Margulies, B.; Kerr, W.G. “SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/βcatenin/Id2 axis.” Stem Cells Dev.2014, 23, 2336-2351. DOI: 10.1089/scd.2014.0122 Park, M.-Y.; Srivastava, N.; Sudan, R.; Viernes, D.R.; Chisholm, J.D.; Engelman, R.W.; Kerr, W.G. “Impaired T cell survival promotes mucosal-Inflammatory disease in SHIP1-deficient mice.” Mucosal Immunol. 2014, 7, 1429-1439. DOI: 10.1038/mi.2014.32 Shah, J.P.; Russo, C.M.; Howard, K.T.; Chisholm, J.D. “Spontaneous Formation of PMB Esters Using4-Methoxybenzyl-2,2,2-trichloroacetimidate.” Tetrahedron Lett. 2014, 55, 1740-1742. DOI: 10.1016/j.tetlet.2014.01.097 Viernes, D.R.; Choi, L.B.; Kerr, W.G.; Chisholm, J.D. “Discovery and Development of Small MoleculeSHIP Phosphatase Modulators.” Med. Res. Rev. 2014, 34, 795-824. DOI: 10.1002/med.21305 Adhikari, A.A.; Shah, J.P.; Howard, K.T.; Russo, C.M.; Wallach, D.R.; Linaburg, M.R.; Chisholm, J.D. “Convenient Formation of DPM Esters Using Diphenylmethyl Trichloroacetimidate.” Synlett 2014, 283-287. DOI: 10.1055/s-0033-1340293 Lerum, R.V.; Russo, C.M.; Marquez, J.M.; Chisholm, J.D. “A Rhodium-Catalyzed Tandem AlkyneDimerization/1,4-Addition Reaction.” Adv. Synth. Catal. 2013, 355, 3485-3491. DOI: 10.1002/adsc.201300743 Carberry, P.; Viernes, D.R.; Choi, L.B.; Fegley, M.W.; Chisholm, J.D. “An Unusual Intramolecular Diels- Alder Approach towards Maoecrystal V.” Tetrahedron Lett. 2013, 54, 1735-1737.DOI: 10.1016/j.tetlet.2013.01.075 Fuhler, G.M.; Brooks, R.; Toms, B.; Iyer, S.; Gengo, E.; Park, M.-Y.; Viernes, D.R.; Chisholm, J.D.; Kerr, W.G. “Therapeutic Potential of SHIP1 and SHIP2 Inhibition in Cancer Cells.” Mol. Med. 2012, 18,65-75. DOI: 10.2119/molmed.2011.00178 Kerr, W.G.; Brooks, R.; Park, M.-Y.; Gumbleton, M.; Iyer, S.; Viernes, D.; Chisholm, J.; Fuhler, G.M. “Abstract C81: Therapeutic potential of SHIP1 and SHIP2 inhibitors in cancer.” Mol. Cancer Ther. 2011,10, C81. DOI: 10.1158/1535-7163.TARG-11-C81 Dhondi, P.K.; Carberry, P.; Choi, L.B.; Chisholm, J.D. “Addition of Alkynes to Aldehydes and ActivatedKetones Catalyzed by Rhodium-Phosphine Complexes.” J. Org. Chem. 2007, 72, 9590-9596. DOI: 10.1021/jo701643h Dhondi, P.K.; Carberry, P.; Chisholm, J.D. “Ligand Effects in the Rhodium-Catalyzed Addition ofAlkynes to Aldehydes and Diketones. Modification of the β-Diketonate Ligand.” Tetrahedron Lett. 2007,48, 8743-8746. DOI: 10.1016/j.tetlet.2007.10.010 Ganci, G.R.; Chisholm, J.D. “Rhodium-Catalyzed Addition of Aryl Boronic Acids to 1,2-Diketones and1,2-Ketoesters.” Tetrahedron Lett. 2007, 48, 8266-8269. DOI:10.1016/j.tetlet.2007.09.137 Yin, J.; Gallis, C.E.; Chisholm, J.D. “Tandem Oxidation/Halogenation of Aryl Allylic Alcohols underMoffatt-Swern Conditions.” J. Org. Chem. 2007, 72, 7054-7057. DOI: 10.1021/jo0711992 Weeden, J.A.; Chisholm, J.D. “Phosphine-Catalyzed Nitroaldol Reactions.” Tetrahedron Lett. 2006, 47,9313-9316. DOI:10.1016/j.tetlet.2006.10.107 Yin, J.; Chisholm, J.D. “Palladium-Catalyzed Addition of Alkynes to Cyclopropenes.” Chem. Commun.2006, 6, 632-634. DOI: 10.1039/B516021A