研究领域

Interactions and processes relevant to laser chemistry and spectroscopy

Professor Chaiken's research interests are broad, although the underlying theme is to obtain a better understanding of the fundamental interactions and processes relevant to all kinds of laser chemistry and spectroscopy. In collaboration with Professor Jerry Goodisman at Syracuse, Chaiken has developed a model to describe coalescence growth. Coalescence growth systems are ubiquitous in nature and particularly important in laser chemical systems. They have successfully applied this model to data on cryogenic helium droplets in free jet expansions collected by Professor J. P. Toennies at the Max Planck Institute (Göttingen, Germany). In collaboration with his colleagues at the Air Force Research Laboratory, Chaiken uses lasers to manipulate the defect states in thin film tungsten oxide and related materials. Such chemistry is relevant to the design, fabrication, and function of nanoscale and microscale photonic devices. He also examines the use of lasers to noninvasively probe biological systems in vivo. His lab produced the first blood volume normalized noninvasive Raman spectrum of human blood in vivo. Shown below, the strength of the features in these spectra are proportional to the concentration of various analytes in the blood, including but not limited to glucose, total protein, albumin, cholesterol, urea, and triglycerides.

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Bussjager, R.; Osman, J.; Chaiken, J.; Getbehead, M.; Hinkel, Capt. D.; McEwen, T. Examination of Tungsten Oxide Based Thin Files for Optical Memory. Proc. SPIE 1999, 3864, 249-251. Chaiken, J.; Finney, W. F.; Peterson, K.; Peterson, C.; Knudson, P. E.; Weinstock, R. S.; Lein, P. Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues. Proc. SPIE 2000, 3907, 89-97. Chaiken, J.; Finney, W. F.; Peterson, C. M.; Peterson, K. P.; Knudson, P. E.; Weinstock, R. S.; Lein, P. Noninvasive in-vivo tissue modulated near-infrared vibrational spectroscopic study of mobile and static tissues: blood chemistry. Proc. SPIE 2000, 3918, 135-143. Chaiken, J.; Finney, W. F.; Knudson, P. E.; Peterson, K. P.; Peterson, C. M.; Yang, X.; Weinstock, R. S. Noninvasive in-vivo tissue modulated Raman spectroscopy of human blood: microcirculation and viscosity effects. Proc. SPIE 2001, 4254, 106-118. Chaiken, J.; Finney, W. F.; Yang, X.; Knudson, P. E.; Peterson, K. P.; Peterson, C. M.; Weinstock, R. S.; Hagrman, D. Progress in the noninvasive in-vivo tissue modulated Raman spectroscopy of human blood. Proc. SPIE 2001, 4254, 216-227. Chaiken, J.; Finney, W. F.; Yang, X.; Peterson, K.; Peterson, C.; Knudson, P. E.; Weinstock, R. S. Hagrman, D. Noninvasive blood analysis by tissue modulated Raman spectroscopy. Proc. SPIE 2001, 4368, 134-145. Chaiken, J.; Voss, E.; Osman, J. M.; Bussjager, R. J. Enabling photonic technologies based on electrochromic and photochromic tungsten oxide. Proc. SPIE 2001, 4386, 150-160. Chaiken, J.; Finney, W. F.; Knudson, P. E.; Weinstock, R. S.; Khan, M.; Bussjager, R. J.; Hagrman, D.; Hagrman, P.; Zhao, Y.; Peterson, C. M.; Peterson, K. The effect of hemoglobin concentration variation on the accuracy and precision of glucose analysis using tissue modulated, noninvasive, in vivo Raman spectroscopy of human blood: a small clinical study. J. Biomed. Opt. 2005, 10(3), 31111. Chaiken, J.; Ellis, K.; Eslick, P.; Piacente, L.;Voss, E. Noninvasive in vivo tissues and pulse modulated Raman Spectroscopy of human capillary blood and plasma. Proc SPIE 2006, 6093, 609305. Goodisman, J.; Chaiken, J. Scaling and the Smoluchowski Equations. J. Chem. Phys. 2006, 125(7), 074304. Chaiken, J.; Goodisman, J.; Kornilov, O.; Toennies, J. P. Application of Scaling and Kinetic Equations to Helium Cluster Size Distributions: Homogeneous Nucleation of a Nearly Ideal Gas. J. Chem. Phys. 2006, 125(7), 074305. Chaiken, J.; Voss, E.; Bussjager, R. J.; Shaheen, G. Towards an Improved Assignment of Spectral Features in Tissue Modulated Non-Invasive Raman Spectroscopy of Human Fingertips. Proc. SPIE 2007, 6430, 643004. Chaiken, J. Laser Chemistry: Spectroscopy, Dynamics and Applications, edited by Helmut H. Teele, Angel Gonzalez Urena, and Robert J. Donovan. J. Am. Chem. Soc. 2007, 129(46), 14525-14526. Chaiken, J.; Goodisman, J.; Deng, B.; Bussjager, R. J.; Shaheen, G. Simultaneous, noninvasive observation of elastic scattering, fluorescence and inelastic scattering as a monitor of blood flow and hematocrit in human fingertip capillary beds. J. Biomed. Opt. 2009, 14(5), 050505. Chaiken, J.; Deng, B.; Bussjager, R. J.; Shaheen, G.; Rice, D.; Stehlik, D.; Fayos, J. Instrument for near-infrared emission spectroscopic probing of human fingertips in vivo. Rev. Sci. Instrum. 2010, 81(3), 034301. Saxena, T.; Deng, B.; Lewis-Clark, E.; Hoellger, K.; Stelzner, D.; Hasenwinkel, J.; Chaiken, J.; Mahadevan-Jansen, A. Near infrared Raman spectroscopic study of reactive gliosis and the glialscar in injured rat spinal cords. Proc. SPIE 2010, 7560, 756001. Deng, B.; Wright, C.; Lewis-Clark, E.; Shaheen, G.; Geier, R.; Chaiken, J.; Mahadevan-Jansen,A. Direct noninvasive observation of near-infrared photobleaching of autofluorescence in human volar side fingertips in vivo. Proc. SPIE 2010, 7560, 75600P. Chaiken, J.; Goodisman, J. On probing human fingertips in vivo using near-infrared light: model calculations. J. Biomed. Opt. 2010, 15(3), 037007.