龚俊波 - 天津大学

个人简介

天津大学长聘教授，博士研究生导师，现任化学工程系副主任，国家工业结晶工程技术研究中心副主任，国家结晶科学与工程国际联合研究中心执行主任。入选国家第四批“万人计划”中青年科技创新领军人才（2019）、科技部中青年科技创新领军人才（2018）、天津市中青年科技创新领军人才（2017）和教育部新世纪优秀人才（2012）等人才支持计划。教育背景 1995－2001 天津大学化学工程博士 1991－1995 天津大学工业化学/技术经济双学士工作经历 2004－至今天津大学化工学院化学工程系副教授/教授/长聘教授，博士生导师 2006－2008 美国密歇根大学药学院博士后/访问学者 2001－2004 天津大学、天津泰达经济技术开发区博士后

研究领域

结晶基础研究主要包括：①成核机理（分子组装路径、多晶型成核等）；②生长机理（单晶和多晶的生长机制、媒晶剂-溶剂效应等）；③晶体工程（无定型、多晶型、盐、溶剂化合物、共晶、MOF、COF等）。晶体产品工程主要包括：①多晶型研究（多晶型筛选，晶型理化性质等）；②晶习工程（晶体形态和粒度调控、媒晶剂开发等）；③粒子工程（颗粒堆积、聚结、结块、破碎等）；④球形结晶（球形聚结、球晶生长等）。结晶过程工程主要包括：①在线反馈控制（过程分析技术、物理和数学模型构建、反馈智能化控制等）；②连续结晶（药物和无机盐的连续结晶过程、连续球形结晶、粒度分布预测、连续手性结晶等）；③计算流体力学（CFD模拟流场分布、多相流颗粒悬浮、结晶产品性能预测等）；④结晶过程放大与智能结晶设备开发（产品质量优化模型与工程放大模型，工艺流程与装置放大，辅助控制与操作软件包等）。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Weiwei Tang, Junbo Gong, Tonglei Li. Kinetic Retraction at the Onset of Concomitant Crystallization and Implication on Polymorphic Formation[J]. Molecular Pharmaceutics, 2022, 19(7), 2676-2680. DOI: 10.1021/acs.molpharmaceut.2c00125. Lan Fang, Zhaoxia Ao, Chenyang Zhao, Shanshan Feng, Dandan Han, Junbo Gong. The solid-liquid equilibrium behavior of 2,7-dihydroxynaphthalene in eleven organic solvents: Thermodynamic analysis and molecular simulation understanding[J]. The Journal of Chemical Thermodynamics, 2022, 170(106781. DOI: https://doi.org/10.1016/j.jct.2022.106781. Shilin Guo, Shanshan Feng, Changyou Yu, Yanbo Liu, Mingyang Chen, Junbo Gong. Sustainable preparation of spherical amphoteric organics:Isoelectric point-spherical agglomeration technology[J]. Powder Technology, 2022, 407(117645. DOI: https://doi.org/10.1016/j.powtec.2022.117645. Maolin Li, Yanbo Liu, Yin Liu, Xin Zhang, Dandan Han, Junbo Gong. pH-driven self-assembly of alcohol-free curcumin-loaded zein-propylene glycol alginate complex nanoparticles[J]. International Journal of Biological Macromolecules, 2022, 213(1057-1067. DOI: https://doi.org/10.1016/j.ijbiomac.2022.06.046. Xiang Kang, Si Li, Mengya Li, Jiahui Li, Dandan Han, Junbo Gong. Natural inhibitors from earthworms for the crystallization of calcium oxalate monohydrate[J]. CrystEngComm, 2022, 24(31), 5597-5604. DOI: 10.1039/D2CE00630H. Shilin Guo, Shanshan Feng, Changyou Yu, Yanbo Liu, Kangli Li, Mingyang Chen, Dandan Han, Junbo Gong. Design of spherical agglomerates via crystallization with a non-toxic bridging liquid: From mechanism to application[J]. Powder Technology, 2022, 408(117725. DOI: https://doi.org/10.1016/j.powtec.2022.117725. Menghui Yao, Lingyu Wang, Shanshan Feng, Jiahui Li, Chen Fang, Suoqing Zhang, Meitang Jin, Li Tong, Zhenguo Gao, Mingyang Chen, Junbo Gong. Improving separation efficiency of crystallization by ultrasound-accelerated nucleation: The role of solute diffusion and solvation effect[J]. Separation and Purification Technology, 2022, 294(121143. DOI: https://doi.org/10.1016/j.seppur.2022.121143. Jiahao Wei, Fan Li, Lina Zhou, Dandan Han, Junbo Gong. Strategies for enhancing peroxymonosulfate activation by heterogenous metal-based catalysis: A review[J]. Chinese Journal of Chemical Engineering, 2022, DOI: https://doi.org/10.1016/j.cjche.2022.07.032. Min Li, Jingjing Sun, Wenjie Kuang, Lina Zhou, Dandan Han, Junbo Gong. Drug–Drug Multicomponent Crystals of Epalrestat: A Novel Form of the Drug Combination and Improved Solubility and Photostability of Epalrestat[J]. Crystal Growth & Design, 2022, 22(8), 5027-5035. DOI: 10.1021/acs.cgd.2c00533. Si Li, Xiang Kang, Qing He, Weiwei Tang, Junbo Gong. Dual Mechanism of Natural Polyphenols on crystal whiskers formation on calcium oxalate monohydrate crystal surface[J]. Applied Surface Science, 2022, 592(153355. DOI: https://doi.org/10.1016/j.apsusc.2022.153355. Zhonghua Li, Jianmin Zhou, Kexuan Zhang, Yinan Zhang, Songgu Wu, Junbo Gong. Playing with Isostructurality from Binary Cocrystals to Ternary Cocrystal Solvates of Quercetin: Tuning Colors of Pigment[J]. Crystal Growth & Design, 2022, 22(9), 5322-5334. DOI: 10.1021/acs.cgd.2c00424. Zhenkai Cen, Lingyu Wang, Jiawei Lin, Zhenjie Gao, Yaobin Zhang, Yuting Cao, Junbo Gong, Dandan Han. Non-Negligible Modulation Role of the Solvent in the Asymmetric Growth of α-Resorcinol[J]. Crystal Growth & Design, 2022, 22(10), 6240-6247. DOI: 10.1021/acs.cgd.2c00804. Shilin Guo, Changyou Yu, Shanshan Feng, Jiahao Wei, Li Tong, Kangli Li, Ye Gao, Pengwei Zhao, Tao Li, Mingyang Chen, Dandan Han, Junbo Gong. Enabling the drug combination of celecoxib through a spherical co-agglomeration strategy with controllable and stable drug content and good powder properties[J]. International Journal of Pharmaceutics, 2022, 626(122180. DOI: https://doi.org/10.1016/j.ijpharm.2022.122180. Zhixu Li, Yiming Ma, Jiawei Lin, Zhenjie Gao, Songgu Wu, Wei Li, Dandan Han, Junbo Gong, Jingkang Wang. The polymorph and crystal habit control of dl-methionine assisted by ultrasound[J]. Journal of Crystal Growth, 2022, 596(126818. DOI: https://doi.org/10.1016/j.jcrysgro.2022.126818. Shanshan Feng, Menghui Yao, Shilin Guo, Jiawei Lin, Zhaoxia Ao, Changyou Yu, Kangli Li, Chun Xun, Limei Yang, Jin He, Mingyang Chen, Junbo Gong. Morphology and microstructure regulation of inorganic salts in an additive-free water system via the self-organization of hierarchical crystal clusters: Mechanism, model, and applications[J]. Chemical Engineering Science, 2022, 262(118053. DOI: https://doi.org/10.1016/j.ces.2022.118053. Yiming Ma, Yue Niu, Huaiyu Yang, Jiayu Dai, Jiawei Lin, Huiqi Wang, Songgu Wu, Qiuxiang Yin, Ling Zhou, Junbo Gong. Prediction and design of cyclodextrin inclusion complexes formation via machine learning-based strategies[J]. Chemical Engineering Science, 2022, 261(117946. DOI: https://doi.org/10.1016/j.ces.2022.117946. Fan Wang, Yanbo Liu, Hui Yan, Dongbo Wang, Zhong Chu, Kangli Li, Li Tong, Mingyang Chen, Junbo Gong. Revealing dissolution behavior and thermodynamic properties of tinidazole in 12 mono-solvents based on experiments and molecular simulation[J]. Journal of Molecular Liquids, 2022, 366(120081. DOI: https://doi.org/10.1016/j.molliq.2022.120081. Ying Wang, Dongbo Wang, Yuan Li, Dandan Han, Ting Shi, Junbo Gong, Md Tarikul Islam. Investigation of solid–liquid equilibrium and thermodynamic models of D-Tagatose in mono-solvents and binary solvents[J]. Chemical Thermodynamics and Thermal Analysis, 2022, 8(100084. DOI: https://doi.org/10.1016/j.ctta.2022.100084. Dongbo Wang, Ying Wang, Yuan Li, Ting Shi, Dandan Han, Junbo Gong. Uncovering the role of impurity sugars on the crystallization of d-tagatose crystal: Experiments and molecular dynamics simulations[J]. Food Chemistry, 2022, 397(133762. DOI: https://doi.org/10.1016/j.foodchem.2022.133762. Zhiao Zhuo, Jiawei Lin, Jinhe Li, Songgu Wu, Weiguo Hu, Junbo Gong. Research progress of mechanically flexible molecular crystals: From bending mechanisms to applications[J]. Chemical Engineering Journal, 2022, 450(138333. DOI: https://doi.org/10.1016/j.cej.2022.138333. Jian Liu, Qingyang Zhang, Mingyang Chen, Zhenguo Gao, Sohrab Rohani, Junbo Gong. A verified open-access AI-based chemical microparticle image database for in-situ particle visualization and quantification in multi-phase flow[J]. Chemical Engineering Journal, 2023, 451(138940. DOI: https://doi.org/10.1016/j.cej.2022.138940. Yanbo Liu, Shuo Wang, Jiahui Li, Shilin Guo, Hui Yan, Kangli Li, Li Tong, Ye Gao, Tao Li, Mingyang Chen, Zhenguo Gao, Junbo Gong. Preparation of ethyl vanillin spherical particles with functions of sustained release and anti-caking by an organic solvent-free process[J]. Food Chemistry, 2023, 402(134518. DOI: https://doi.org/10.1016/j.foodchem.2022.134518. Shuo Wang, Yanbo Liu, Shilin Guo, Hui Yan, Kangli Li, Li Tong, Tao Li, Mingyang Chen, Zhenguo Gao, Junbo Gong. Design of Single and Multicomponent Drug Spherical Particles with Improved Powder Properties in Water Instead of Organic Solvents: A Case Study of Gemfibrozil[J]. ACS Sustainable Chemistry & Engineering, 2022, 10(37), 12411-12422. DOI: 10.1021/acssuschemeng.2c03982. Haibin Qu, Jiayin Zhang, Guimin Zhang, Zhonghua Li, Yu Liu, Songgu Wu, Junbo Gong. Structural Insights into the Highly Solvating System of Axitinib via Binary and Ternary Solvates[J]. Crystal Growth & Design, 2022, 22(2), 1083-1093. DOI: 10.1021/acs.cgd.1c01021. Jingjing Sun, Lina Jia, Mengwei Wang, Yu Liu, Min Li, Dandan Han, Junbo Gong. Novel Drug–Drug Multicomponent Crystals of Epalrestat–Metformin: Improved Solubility and Photostability of Epalrestat and Reduced Hygroscopicity of Metformin[J]. Crystal Growth & Design, 2022, 22(2), 1005-1016. DOI: 10.1021/acs.cgd.1c00810. Lan Fang, Yiming Ma, Yuntian Xiao, Zhonghua Li, Zhenguo Gao, Songgu Wu, Sohrab Rohani, Junbo Gong. Theoretical and Structural Understanding of the Different Factors Influencing the Formation of Multicomponent Crystals of 2,4-Dichlorophenoxyacetic Acid with N-heterocyclic Compounds[J]. Crystal Growth & Design, 2022, 22(3), 1707-1719. DOI: 10.1021/acs.cgd.1c01239. Shengzhe Jia, Ye Gao, Zongqiu Li, Teng Zhang, Jian Liu, Jingkang Wang, Zhenguo Gao, Junbo Gong. Process intensification and control strategies in cooling crystallization: Crystal size and morphology optimization of α-PABA[J]. Chemical Engineering Research and Design, 2022, 179(265-276. DOI: https://doi.org/10.1016/j.cherd.2022.01.029. Zeren Shang, Mingdi Liu, Weiguo Hu, Tong Deng, Xin Su, Baohong Hou, Jingkang Wang, Junbo Gong. Construction and application of a qualitative and quantitative analysis system of three boscalid polymorphs based on solid-state analytical methods and chemometric tools[J]. CrystEngComm, 2022, 24(16), 3096-3108. DOI: 10.1039/D2CE00152G. Peng Yang, Ian Rosbottom, Zhonghua Li, Vivek Verma, Songgu Wu, Junbo Gong, Jerry Y. Y. Heng. The heterogeneous nucleation of pimelic acid under the effect of a template: experimental research and molecular simulation[J]. CrystEngComm, 2022, 24(15), 2825-2835. DOI: 10.1039/D1CE01591E. Shengzhe Jia, Peng Yang, Zhenguo Gao, Zhonghua Li, Chen Fang, Junbo Gong. Recent progress in antisolvent crystallization[J]. CrystEngComm, 2022, 24(17), 3122-3135. DOI: 10.1039/D2CE00059H. Mengya Li, Dandan Han, Junbo Gong. What roles do alkali metal ions play in the pathological crystallization of uric acid?[J]. CrystEngComm, 2022, 24(20), 3749-3761. DOI: 10.1039/D2CE00107A. Jiawei Lin, Zhenxiao Guo, Keke Zhang, Pei Zhao, Songgu Wu, Jun Xu, Junbo Gong, Ying Bao. Mechanical Motion and Modulation of Thermal-Actuation Properties in a Robust Organic Molecular Crystal Actuator[J]. Advanced Functional Materials, 2022, 32(29), 2203004. DOI: https://doi.org/10.1002/adfm.202203004. Tiantian Tao, Zhenguo Gao, Chen Fang, Jiayin Zhang, Jun Xu, Huaiyu Yang, Junbo Gong. Enhancement of protein crystallization with the application of Taylor vortex and Poly(ionic liquid)s[J]. Chemical Engineering Science, 2022, 252(117501. DOI: https://doi.org/10.1016/j.ces.2022.117501. Peng Yang, Shengzhe Jia, Yan Wang, Zongqiu Li, Songgu Wu, Jingkang Wang, Junbo Gong. Dissolution behavior, thermodynamic and kinetic analysis of malonamide by experimental measurement and molecular simulation[J]. Chinese Journal of Chemical Engineering, 2022, DOI: https://doi.org/10.1016/j.cjche.2022.03.012. Wenjie Kuang, Jian Liu, Xia Lin, Songgu Wu, Junbo Gong, Qiuxiang Yin, Jingkang Wang. Insoluble Salt of Memantine with a Unique Fluorescence Phenomenon[J]. Molecular Pharmaceutics, 2022, 19(5), 1389-1399. DOI: 10.1021/acs.molpharmaceut.1c00931. Zhonghua Li, Haibin Qu, Lan Fang, Songgu Wu, Junbo Gong. A new strategy to design isostructural salts: the case of the antitumor drug dimethylaminomicheliolide[J]. Chinese Chemical Letters, 2022, DOI: https://doi.org/10.1016/j.cclet.2022.05.018. Yanbo Liu, Yiming Ma, Changyou Yu, Ye Gao, Kangli Li, Li Tong, Mingyang Chen, Junbo Gong. Spherical agglomeration of high melting point drugs in water at low temperature by developing a two-step oiling-out mechanism and the design strategy[J]. Green Chemistry, 2022, 24(15), 5779-5791. DOI: 10.1039/D2GC01498J. Jian Liu, Wenjie Kuang, Jiaqiang Liu, Zhenguo Gao, Sohrab Rohani, Junbo Gong. In-situ multi-phase flow imaging for particle dynamic tracking and characterization: Advances and applications[J]. Chemical Engineering Journal, 2022, 438(135554. DOI: https://doi.org/10.1016/j.cej.2022.135554. Jie Sun, Yaping Wang, Zhenguo Gao, Junbo Gong, Weiwei Tang. Additive-assisted preferential crystallization of racemic component: A case of norvaline[J]. Journal of Industrial and Engineering Chemistry, 2022, 110(206-216. DOI: https://doi.org/10.1016/j.jiec.2022.02.054. Guangle Wang, Zeren Shang, Mingdi Liu, Weibing Dong, Haichao Li, Haiqing Yin, Junbo Gong, Songgu Wu. Insight into the Nucleation Mechanism of p-Methoxybenzoic Acid in Ethanol-Water System from Metastable Zone Width[J]. Molecules, 2022, 27(13), 4085. Lan Fang, Jiahao Wei, Zhiqing Li, Yuntian Xiao, Yu Liu, Zhenguo Gao, Songgu Wu, Sohrab Rohani, Junbo Gong. Multiple Mechanical Behaviors in One Crystal of 2,4-Dichlorophenoxyacetic Acid Form II: Thermomechanical Effect and Elastic Deformation[J]. Crystal Growth & Design, 2022, 22(6), 3680-3687. DOI: 10.1021/acs.cgd.1c01524.