Farokhzad, Omid - Harvard Medical School - Brigham and Women’s Hospital

个人简介

Omid Farokhzad is a Professor at Harvard Medical School (HMS) and a physician-scientist in the Department of Anesthesiology at Brigham and Women’s Hospital (BWH). Dr. Farokhzad established and directs the Center for Nanomedicine at BWH. He is a faculty member of the Brigham Research Institute Cancer Research Center and the Dana Farber/Harvard Cancer Center. Dr. Farokhzad and his team of scientists have developed a myriad of nanotechnologies for medical applications. He has authored more than 150 papers (>45,000 citations; H-Index 87) and is an inventor of more than 150 issued / pending patents worldwide. The technologies that Dr. Farokhzad and colleagues have developed formed the basis for the launch of 5 biotechnology companies: BIND Therapeutics (clinical stage public company acquired by Pfizer), Selecta Biosciences (clinical stage public company), Tarveda Therapeutics (clinical stage private company), Placon Therapeutics (clinical stage private company), Seer Biosciences (preclinical stage private company). These companies are translating the aforementioned academic innovations toward commercialization and societal impact. Dr. Farokhzad has served in various capacities on the Board of Directors and the Scientific Advisory Board of these companies. He was a recipient of the 2013 RUSNANOPRIZE, one of the largest international nanotechnology prizes, for the development and industrialization of nanoparticle technologies for medical applications. In 2014, he received the Golden Door Award from the International Institute of New England for his societal and economic impact as a naturalized USA citizen. In 2015, he was named as one of The Worldview 100 by Scientific American, which recognized visionaries who shape biotechnology around the world. In 2016, he was among the recipients of the Ellis Island Medal of Honor for his scientific, societal and economic contributions to America as an immigrant. Dr. Farokhzad was elected to the College of the Fellows of the American Institute of Medical and biological Engineering. He was selected by Thomson Reuters among the Highly Cited Researchers in 2014, 2015, 2016 and 2017. The Boston Globe selected him among the top innovators in Massachusetts and the Boston Business Journal selected him among the Health Care Champions for his innovations. In 2012, he was among the regional Ernst & Young Entrepreneur of the Year awardees. He serves on numerous editorial boards including as Associate Editor of ACS Nano (impact factor ~14). Dr. Farokhzad completed his post-graduate clinical and post-doctoral research trainings, respectively, at the BWH/HMS and MIT in the laboratory of Institute Professor Robert Langer. He received his M.D. and M.A. from Boston University School of Medicine and his M.B.A. from the MIT Sloan School of Management.

研究领域

Nanomedicine and Biomaterials Nanotechnology has generated a significant impact in nearly every aspect of science. Our research seeks novel nanomaterials and nanotechnologies in order to develop advanced drug delivery systems with the promise to improve health care. Highly interdisciplinary and translational, our research is focused on multifunctional, nanoparticle-based drug delivery systems. We seek to improve nanoparticle synthesis and formulation and its therapeutic efficacy. Additionally, we develop robust engineering processes to accelerate translation of nanoparticle-based drugs into the drug development pipeline. At the same time, we emphasize a fundamental understanding of the interface between nanomaterials and the biological system, all in order to aid in nanoparticle drug development.

近期论文

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Ling X, Tu J, Wang J, Shajii A, Kong N, Feng C, Zhang Y, Yu M, Xie T, Bharwani Z, Aljaeid BM, Shi B, Tao W, Farokhzad OC. Glutathione-Responsive Prodrug Nanoparticles for Effective Drug Delivery and Cancer Therapy, ACS Nano (2019) Jan 22; 13 (1), 357-370. Full Text Yu M, Ortega CA, Si K, Molinaro R, Schoen FJ, Leitao R, Xu X, Mahmoudi M, Ahn S, Liu J, Saw PE, Lee IH, Brayner M, Lotfi A, Shi J, Libby P, Jon S, Farokhzad OC. Nanoparticles targeting extra domain B of fibronectin−specific to the atherosclerotic lesion types III, IV, and V−enhance plaque detection and cargo delivery, Theranostics (2018) Nov 15; 8(21): 6008-6024. Full Text Xu X, Wu J, Liu S, Li L, Saw PE, Tao W, Li Y, Krygsman L, Yegnasubramanian S, Marzo AMD, Shi J, Bieberich CJ, Farokhzad OC. Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy, Small (2018) Sep 17; 14 (41), 1802565. Full Text Islam MA, Xu Y, Tao W, Ubellacker JM, Lim M, Aum D, Lee GY, Zhou K, Zope H, Yu M, Cao W, Oswald JT, Dinarvand M, Mahmoudi M, Langer R, Kantoff PW, Farokhzad OC, Zetter BR, Shi J. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA, Nature Biomedical Engineering (2018) Sep 17; 2, 850–864. Full Text Tao W, Ji X, Zhu X, Li L, Wang J, Zhang Y, Saw PE, Li W, Kong N, Islam MA, Gan T, Zeng X, Zhang H, Mahmoudi M, Tearney GJ, Farokhzad OC. Two-Dimensional Antimonene-based Photonic Nanomedicine for Cancer Theranostics, Adv Mater (2018) Jul 24; 30 (38), 1802061. Full Text Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Lippard SJ, Farokhzad OC, Shi J, Wu J. Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance, Nano Lett (2018) Jun 19; 18 (7), 4618–4625. Full Text Abadi PPSS, Garbern JC, Behzadi S, Hill MJ, Tresback JS, Heydari T, Ejtehadi MR, Ahmed N, Copley E, Aghaverdi H, Lee RT, Farokhzad OC, Mahmoudi M. Engineering of Mature Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Using Substrates with Multiscale Topography, Adv Funct Mater (2018) Mar 13;28 (19), 1870128. Full Text Behzadi S, Vatan NM, Lema K, Nwaobasi D, Zenkov I, Abadi PPSS, Khan DA, Corbo C, Aghaverdi H, Farokhzad OC, Mahmoudi M. Flat Cell Culturing Surface May Cause Misinterpretation of Cellular Uptake of Nanoparticles, Adv Biosyst (2018) Mar 8; 2, 1800046. Full Text Zheng M, Tao W, Zou Y, Farokhzad OC, Shi B. Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy, Trends Biotechnol (2018) Feb 5;36(5):562-575. Full Text 150. Zhu X, Ji X, Kong N, Chen Y, Mahmoudi M, Xu X, Ding L, Tao W, Cai T, Li Y, Gan T, Barrett A, Bharwani Z, Chen H, Farokhzad OC. Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis Enhanced Synergistic Cancer Therapy, ACS Nano (2018) Feb 6;12 (3), 2922–2938. Full Text Chan WWC, Chhowalla M, Farokhzad OC, Glotzer S, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kataoka K, Khademhosseini A, Kotov NA, Lee ST, Li Y, Millstone J, Möhwald H, Mulvaney PC, Nel AE, Nordlander PJ, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee ATS, Willson CG, Fernandez LE, Weiss PS. A Big Year Ahead for Nano in 2018, ACS Nano (2017) Dec 26; 11(12):11755-11757. Full Text Bertrand N, Grenier P, Mahmoudi M, Lima EM, Appel EA, Dormont F, Lim JM, Karnik R, Langer R, Farokhzad OC. Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics, Nature Communications (2017) Oct 3; 8:777. Full Text Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyopathy, Nature Nanotechnology (2017) Sep 6; 2017,12,168–182. Full Text Behzadis S, Luther GA, Harris MB, Farokhzad OC, Mahmoudi M. Nanomedicine for safe healing of bone trauma: Opportunities and challenges, Biomaterials (2017) Sep 4; 2017,146,845–855. Full Text Wang J, Tao W, Chen X, Farokhzad OC, Liu G. Emerging Advances in Nanotheranostics with Intelligent Bioresponsive Systems, Theranostics. (2017) Sep 5; 16(7):3915-3919. Full Text Kakkar A, Traverso G, Farokhzad OC, Weissleder R, Langer R. Evolution of macromolecular complexity in drug delivery systems, Nature Reviews Chemistry (2017) Aug 8; 2017,1:0063. Full Text Yu M, Amengual J, Menon A, Kamaly N, Zhou F, Xu X, Saw PE, Lee SJ, Si K, Ortega CA, Choi WI, Lee IH, Bdour Y, Shi J, Mahmoudi M, Jon S, Fisher EA, Farokhzad OC. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr−/− Mice, Adv Healthc Mater. (2017) Jul 21; [Epub ahead of print]. Full Text Shi B, Zheng M, Tao W, Chung R, Jin D, Ghaffari D, Farokhzad OC. Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery System, Biomacromolecules. (2017) Jun 29; [Epub ahead of print]. Full Text Xu X, Saw PE, Tao W, Li Y, Ji X, Bhasin S, Liu Y, Ayyash D, Rasmussen J, Huo M, Shi J, Farokhzad OC. ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy, Adv Mater. (2017) Jul 6; [Epub ahead of print]. Full Text