Zhang, Yong - Stevens Institute of Technology - Department of Chemistry, Chemical Biology and Biomedical Engineering

个人简介

1997 Ph.D. Chemistry, Nanjing University 1993 B.S. Chemistry, Nanjing University -------------------------------------------------------------------------------- 2007-2010 Assistant Professor Chemistry, University of Southern Mississippi 2000- 2007 Research Scientist, University of Illinois Urbana-Champaign (with Eric Oldfield) 1999-2000 Associate Professor of Chemistry (Tenured), Nanjing University

研究领域

Structural and mechanistic investigation of metallobiomolecules involved in interactions with small molecules (HNO, NO etc) of vital importance in biomedical sciences Mechanistic investigation and catalyst development for sustainable and atom-economical catalytic reactions with high selectivities Mechanistic invesitgation of metals' roles on neurodegenerative disorders and inhibitor design Deciphering novel spectroscopic fingerprints of biomolecules

近期论文

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Selected from 95 Total Peer-reviewed Publications by 2014 July: including 20 in J. Am. Chem. Soc., 4 in Angew. Chem. Int. Ed., 2 in Proc. Natl. Acad. Sci. U.S.A.. (See complete list) . Khade RL, Fan WC, Ling Y, Yang L, Oldfield E, Zhang Y*. (2014). "Iron Porphyrin Carbenes as Catalytic Intermediates: Structures, Mössbauer and NMR Spectroscopic Properties, and Bonding", Angew. Chem. Int. Ed., 53 7574-7578. Zhang J, Ugrinov A, Zhang Y*, Zhao PJ. (2014). "Exploring Bis-Cyclometalated Ru(II) Complexes as Active Catalyst Precursors: Room-Temperature Alkene-Alkyne Coupling for 1,3-Diene Synthesis", Angew. Chem. Int. Ed., 53 8437-8440. Span I, Wang K, Eisenreich W, Bacher A, Zhang Y, Oldfield E, Groll M. (2014). "Insights into the Binding of Pyridines to the Fe4S4 Cluster of the Enzyme IspH", J. Am. Chem. Soc., 136 7926-7932. Chakraborty S, Reed J, Ross M, Nilges MJ, Petrik ID, Ghosh S, Hammes-Schiffer S, Sage JT, Zhang Y, Schulz CE, Lu Y. (2014). "Spectroscopic and Computational Study of a Non-heme Iron-Nitrosyl Center in a Biosynthetic Model of Nitric Oxide Reductases", Angew. Chem. Int. Ed., 53 2417-2421. Li JK, Wang K, Smirnova, Khade RL, Zhang Y, Oldfield E. (2013). "Isoprenoid Biosynthesis: Ferraoxetane or Allyl Anion Mechanism for IspH Catalysis", Angew. Chem. Int. Ed, 52 6522-25. Liu YL, Guerra F, Wang K, Huang CC, Wang WX, Zhu W, Houlihan K, Li Z, Demeler B, Zhang Y, Nair S, Oldfield E. (May 29, 2012). "Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins", Proc. Natl. Acad. Sci. U. S. A., 109 (22), 8558-8563. Yang L, Ling Y, Zhang Y*. (2011). "HNO Binding in a Heme Protein: Structures, Spectroscopic Properties, and Stabilities", J. Am. Chem. Soc., 35 (133), 13814-13817. Wang WX, Li JK, Wang K, Huang CC, Zhang Y, Oldfield E. (2010). "Organometallic Mechanism of Action and Inhibition of the 4Fe-4S Isoprenoid Biosynthesis Protein GcpE", Proc. Natl. Acad. Sci. U. S. A., 107 (25), 11189-93. Wang K, Wang WX, No JH, Zhang YH, Zhang Y, Oldfield E. (2010). "Inhibition of the Fe4S4 Cluster-containing Protein IspH (LytB): EPR, Metallacycles and Mechanisms.", J. Am. Chem. Soc, 132 (19), 6719-6727 . Ling Y, Mills C, Weber R, Yang L, Zhang Y*. (2010). "NMR, IR/Raman, and Structural Properties in HNO and RNO (R = alkyl and aryl) Metalloporphyrins with Implications for the HNO-myoglobin Complex", J. Am. Chem. Soc., 132 (5), 1583-91. Stevenson S, Ling Y, Coumbe CE, Mackey MA, Confait BS, Phillips JP, Dorn HC, Zhang Y*. (2009). J. Am. Chem. Soc., 131 (49), 17780-82. Ling Y, Zhang Y*. (2009). "Mössbauer, NMR, Geometric, and Electronic Properties in S = 3/2 Iron Porphyrins", J. Am. Chem. Soc., 131 (18), 6386-8. Zhang Y, Oldfield E.. (2008). "NMR Hyperfine Shifts in Blue Copper Proteins: a Quantum Chemical Investigation", J. Am. Chem. Soc., 130 (12), 3814-23. Mukkamala D, Zhang Y, Oldfield E.. (2007). "A Solid State 13C NMR, Crystallographic and Quantum Chemical Investigation of Phenylalanine and Tyrosine Residues in Dipeptides and Proteins", J. Am. Chem. Soc., 129 (23), 7385-92. Kervern G, Pintacuda G, Zhang Y, Oldfield E, Roukoss C, Kuhn E, Herdtweck E, Basset JM, Cadars S, Lesage A, Coperet C, Emsley L.. (2006). "Solid-state NMR of a paramagnetic DIAD-Fe(II) catalyst: sensitivity, resolution enhancement, and structure-based assignment", J. Am. Chem. Soc., 128 (41), 13545-52. Mao J, Mukherjee S, Zhang Y, Cao R, Sanders JM, Song YC, Zhang YH, Meints GA, Gao YG, Mukkamala D, Hudock MP, Oldfield E.. "A Solid State NMR, Crystallographic and Computational Investigation of Bisphosphonates and Farnesyl Diphosphate Synthase-Bisphosphonate Complexes", J. Am. Chem. Soc., 128 (45), 14485-97. Zhang Y, Sun H, Oldfield E.. "Solid-state NMR Fermi Contact and Dipolar Shifts in Organometallic Complexes and Metalloporphyrins", J. Am. Chem. Soc., 127 (11), 3652-3. Zhang Y, Mukherjee S, Oldfield E. (2005). "67Zn NMR Chemical Shifts and Electric Field Gradients in Zinc Complexes: A Quantum Chemical Investigation", J. Am. Chem. Soc., 127 (8), 2370-1. Cheng F, Sun H, Zhang Y, Mukkamala D, Oldfield E.. (2005). "A Solid State 13C NMR, Crystallographic and Quantum Chemical Investigation of Chemical Shifts and Hydrogen Bonding in Histidine Dipeptides", J. Am. Chem. Soc., 127 (36), 12544-54.