Hughes, Chambers C. - Scripps Institution of Oceanography - CENTER FOR MARINE BIOTECHNOLOGY BIOMEDICINE

个人简介

Degrees: B.S., Geneseo College (SUNY) Ph.D., University of California, Berkeley Chambers C. Hughes is an assistant professor of chemical biology at the Center for Marine Biotechnology and Biomedicine at Scripps Institution of Oceanography, UC San Diego. His research focuses on the discovery and chemical biology of marine natural products. Dr. Hughes was born and raised in western New York. In 1999 he graduated with a B.S. in biochemistry and a minor in Latin from Geneseo College, a selective college in the State University of New York (SUNY) system. In 2004 he completed a Ph.D. in chemistry from the University of California, Berkeley. There, he worked with Professor Dirk Trauner on the chemical synthesis of two terrestrial and two marine natural products. He was the first member of the then-nascent Trauner research group to earn a doctorate. Next, Hughes held an extended postdoctoral/research associate appointment with Professor William Fenical at Scripps Institution of Oceanography. During this time, he led efforts in the discovery, synthesis, and chemical biology of several marine-derived bacterial natural products. Given their potent anticancer and antibacterial properties, these compounds have the potential to treat diseases in humans. In 2012 Hughes was hired as assistant professor at Scripps. He continues to explore ocean sediments for bacteria that produce novel natural products and aims to understand how these metabolites function in complex cellular environments.

研究领域

Marine Microbial Natural Products Natural Product Target Identification Natural Product Total Synthesis and Semisynthesis

近期论文

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Kearney, SE, Zahoranszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao TG, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang RL, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao JH, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu ZR, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang YF, Ren TJ, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia MH, Guha R, Rohde JM. 2018. Canvass: A crowd-sourced, natural-product screening library for exploring biological space. Acs Central Science. 4:1727-1741. 10.1021/acscentsci.8b00747 Abstract Castro-Falcon, G, Seiler GS, Demir O, Rathinaswamy MK, Hamelin D, Hoffmann RM, Makowski SL, Letzel AC, Field SJ, Burke JE, Amaro RE, Hughes CC. 2018. Neolymphostin A Is a covalent phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitor that employs an unusual electrophilic vinylogous ester. Journal of Medicinal Chemistry. 61:10463-10472. 10.1021/acs.jmedchem.8b00975 Abstract Castro-Falcon, G, Millan-Aguinaga N, Roullier C, Jensen PR, Hughes CC. 2018. Nitrosopyridine probe to detect polyketide natural products with conjugated alkenes: Discovery of novodaryamide and nocarditriene. Acs Chemical Biology. 13:3097-3106. 10.1021/acschembio.8b00598 Abstract Patin, NV, Floros DJ, Hughes CC, Dorrestein PC, Jensen PR. 2018. The role of inter-species interactions in Salinispora specialized metabolism. Microbiology-Sgm. 164:946-955. 10.1099/mic.0.000679 Abstract Mafu, S, Ding YZ, Murphy KM, Yaacoobi O, Addison JB, Wang Q, Shen ZX, Briggs SP, Bohlmann J, Castro-Falcon G, Hughes CC, Betsiashvili M, Huffaker A, Schmelz EA, Zerbe P. 2018. Discovery, biosynthesis and stress-related accumulation of dolabradiene-derived defenses in maize. Plant Physiology. 176:2677-2690. 10.1104/pp.17.01351 Abstract Gallagher, KA, Wanger G, Henderson J, Llorente M, Hughes CC, Jensen PR. 2017. Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environmental Microbiology. 19:2182-2191. 10.1111/1462-2920.13700 Abstract Reimer, D, Hughes CC. 2017. Thiol-based probe for electrophilic natural products reveals that most of the ammosamides are artifacts. Journal of Natural Products. 80:126-133. 10.1021/acs.jnadprod.6b00773 Abstract Castro-Falcon, G, Hahn D, Reimer D, Hughes CC. 2016. Thiol probes to detect electrophilic natural products based on their mechanism of action. Acs Chemical Biology. 11:2328-2336. 10.1021/acschembio.5b00924 Abstract Richter, TKS, Hughes CC, Moore BS. 2015. Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway. Environmental Microbiology. 17:2158-2171. 10.1111/1462-2920.12669 Abstract Alvarez-Mico, X, Jensen PR, Fenical W, Hughes CC. 2013. Chlorizidine, a Cytotoxic 5H-Pyrrolo 2,1-a isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp. Organic Letters. 15:988-991. 10.1021/ol303374e Abstract Yang, MH, Liu Z, Hughes C, Stern AM, Wang H, Zhong ZT, Kan B, Fenical W, Zhu J. 2013. Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence. Proceedings of the National Academy of Sciences of the United States of America. 110:2348-2353. 10.1073/pnas.1218039110 Abstract Yamanaka, K, Ryan KS, Gulder TAM, Hughes CC, Moore BS. 2012. Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis. Journal of the American Chemical Society. 134:12434-12437. 10.1021/ja305670f Abstract Haste, NM, Hughes CC, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME. 2011. Pharmacological properties of the marine natural product marinopyrrole a against methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 55:3305-3312. 10.1128/aac.01211-10 Abstract Hughes, CC, Kauffman CA, Jensen PR, Fenical W. 2010. Structures, reactivities, and antibiotic properties of the marinopyrroles A-F. Journal of Organic Chemistry. 75:3240-3250. 10.1021/jo1002054 Abstract Hughes, CC, Fenical W. 2010. Total synthesis of the ammosamides. Journal of the American Chemical Society. 132:2528-2529. 10.1021/ja9106572 Abstract Hughes, CC, Fenical W. 2010. Antibacterials from the sea. Chemistry-a European Journal. 16:12512-12525. 10.1002/chem.201001279 Abstract Pangerl, M, Hughes CC, Trauner D. 2010. Total Synthesis of Newbouldine via Reductive N–N Bond Formation. Tetrahedron. 66:6626-6631. Abstract