Marchesi, Vincent T - Yale University

个人简介

I am a graduate of Yale College (BA 1957), Oxford University (D.Phil.1961) and the Yale School of Medicine (MD, 1963). I trained in anatomical pathology at Washington University (1963-65), spent a post-doctoral year at Rockefeller University with George Palade, and served in the USPHS at the NIH from1966 to 1972. I was recruited to Yale by Lewis Thomas in 1972, and a year later was named the Anthony N. Brady Professor of pathology and chair of the department and Pathologist-in-Chief of the Yale New Haven Hospital. In 1991 I became the Director of the Boyer Center for Molecular Medicine. I am a member of the National Academy of Sciences and the Institute of Medicine. MD Yale University School of Medicine (1963) PhD Oxford University (1961) BA Yale University (1957)

研究领域

Alzheimer Disease; Autoantibodies; Cell Biology; Pathology; Protein Folding

近期论文

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Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis. Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis. Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S, Kobayashi KS, Marchesi VT, Flavell RA. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9785-90. A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Matza D, Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A, McMahon-Pratt D, Marchesi VT, Flavell RA. Immunity. 2008 Jan;28(1):64-74. The relevance of research on red cell membranes to the understanding of complex human disease: a personal perspective. The relevance of research on red cell membranes to the understanding of complex human disease: a personal perspective. Marchesi VT. Annu Rev Pathol. 2008;3:1-9. An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease. An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease. Marchesi VT. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9093-8. Marchesi VT: Gain-of-function somatic mutations contribute to inflammation and blood vessel damage that lead to Alzheimer dementia: a hypothesis. FASEB J. 2016 Feb; 2015 Nov 2. PMID: 26527064 Marchesi VT: Alzheimer's disease and CADASIL are heritable, adult-onset dementias that both involve damaged small blood vessels. Cell Mol Life Sci. 2014 Mar; 2013 Dec 31. PMID: 24378989 Marchesi VT: Alzheimer's disease 2012: the great amyloid gamble. Am J Pathol. 2012 May; 2012 Apr 1. PMID: 22472273 Marchesi VT: Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy. FASEB J. 2011 Jan. PMID: 21205781 Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S, Kobayashi KS, Marchesi VT, Flavell RA: Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis. Proc Natl Acad Sci U S A. 2009 Jun 16; 2009 Jun 2. PMID: 19497879 Marchesi VT: The relevance of research on red cell membranes to the understanding of complex human disease: a personal perspective. Annu Rev Pathol. 2008. PMID: 18039128 Matza D, Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A, McMahon-Pratt D, Marchesi VT, Flavell RA: A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity. 2008 Jan. PMID: 18191595 Marchesi VT: An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Jun 28; 2005 Jun 20. PMID: 15967987 Komuro A, Masuda Y, Kobayashi K, Babbitt R, Gunel M, Flavell RA, Marchesi VT: The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells. Proc Natl Acad Sci U S A. 2004 Mar 23; 2004 Mar 8. PMID: 15007166