Colón-Ramos, Daniel Alfonso - Yale University

个人简介

Daniel Colón-Ramos was born and raised in Puerto Rico. He completed his B.A. at Harvard University, his PhD in the lab of Dr. Sally Kornbluth at Duke University and was a postdoctoral fellow in the lab of Dr. Kang Shen at Stanford University. The Colón-Ramos lab is interested in how synapses are precisely assembled to build the neuronal architecture that underlies behavior. To address this, they developed tools in the thermotaxis circuit of C. elegans. Their system enables unbiased genetic screens to identify novel pathways that instruct synaptogenesis in vivo, and single-cell manipulation of these pathways to understand how they influence behavior. As mechanisms underlying synapse structure and function are conserved, the research program seeks to enhance our understanding of synaptic cell biology in higher organisms, which may be important for disease. PhD Duke University Medical Center (2003) AB Harvard College (1998) Postdoctoral fellow Stanford University

研究领域

Behavior; Brain; Cell Biology; Neurons

近期论文

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Synapse location during growth depends on glia location Shao Z, Watanabe S, Christensen R, Jorgensen EM, Colón-Ramos DA. Synapse location during growth depends on glia location. Cell, 2013 Jul 18;154(2):337-50. PMID:23870123 Netrin instructs neurosecretory terminal targeting in serotonin neurons of C. elegans Nelson JC, Colón-Ramos DA. Netrin instructs neurosecretory terminal targeting in serotonin neurons of C. elegans. Journal of Neuroscience, 2013 Jan 23;33(4):1366-76. PMID: 23345213 Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin. Stavoe A.K., Nelson J.C., Martínez-Velázquez L.A., Klein M, Samuel A.D., Colón-Ramos D.A. (2012)Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin. Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10/Lamellipodin and the actin cytoskeleton Stavoe A.K., Colón-Ramos D.A. Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10/Lamellipodin and the actin cytoskeleton. Journal of Cell Biology, 2012 Apr 2;197(1):75-88. PMCID:3317799 A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development Christensen R., de la Torre-Ubieta L., Bonni A., Colón-Ramos DA. A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development 2011 Dec; 138(23)5257-67 Glia promote local synaptogenesis through UNC-6/Netrin signaling in C. elegans Colón-Ramos, D.A., Margeta, M., Shen, K., (2007). Glia promote local synaptogenesis through UNC-6/Netrin signaling in C. elegans. Science. 318 (5847): 103-6. Ardiel EL, Kumar A, Marbach J, Christensen R, Gupta R, Duncan W, Daniels JS, Stuurman N, Colón-Ramos D, Shroff H: Visualizing Calcium Flux in Freely Moving Nematode Embryos. Biophys J. 2017 May 9. PMID: 28494967 Colón-Ramos DA: The need to connect: on the cell biology of synapses, behaviors, and networks in science. Mol Biol Cell. 2016 Nov 1. PMID: 27799494 Kumar A, Christensen R, Guo M, Chandris P, Duncan W, Wu Y, Santella A, Moyle M, Winter PW, Colón-Ramos D, Bao Z, Shroff H: Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM). Biol Bull. 2016 Aug. PMID: 27638693 Stavoe AK, Hill SE, Hall DH, Colón-Ramos DA: KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses. Dev Cell. 2016 Jul 25; 2016 Jul 7. PMID: 27396362 Jang S, Nelson JC, Bend EG, Rodríguez-Laureano L, Tueros FG, Cartagenova L, Underwood K, Jorgensen EM, Colón-Ramos DA: Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function. Neuron. 2016 Apr 20; 2016 Apr 7. PMID: 27068791 Christensen RP, Bokinsky A, Santella A, Wu Y, Marquina-Solis J, Guo M, Kovacevic I, Kumar A, Winter PW, Tashakkori N, McCreedy E, Liu H, McAuliffe M, Mohler W, Colón-Ramos DA, Bao Z, Shroff H: Untwisting the Caenorhabditis elegans embryo. Elife. 2015 Dec 3; 2015 Dec 3. PMID: 26633880 González-Espada W, Díaz-Muñoz G, Feliú-Mójer M, Flores-Otero J, Fortis-Santiago Y, Guerrero-Medina G, López-Casillas M, Colón-Ramos DA, Fernández-Repollet E: Assessing a Science Graduate School Recruitment Symposium. Cuad Investig Educ. 2015 Dec. PMID: 26770074 Santella A, Catena R, Kovacevic I, Shah P, Yu Z, Marquina-Solis J, Kumar A, Wu Y, Schaff J, Colón-Ramos D, Shroff H, Mohler WA, Bao Z: WormGUIDES: an interactive single cell developmental atlas and tool for collaborative multidimensional data exploration. BMC Bioinformatics. 2015 Jun 9; 2015 Jun 9. PMID: 26051157 Kumar A, Wu Y, Christensen R, Chandris P, Gandler W, McCreedy E, Bokinsky A, Colón-Ramos DA, Bao Z, McAuliffe M, Rondeau G, Shroff H: Dual-view plane illumination microscopy for rapid and spatially isotropic imaging. Nat Protoc. 2014 Nov; 2014 Oct 9. PMID: 25299154 Luo L, Wen Q, Ren J, Hendricks M, Gershow M, Qin Y, Greenwood J, Soucy ER, Klein M, Smith-Parker HK, Calvo AC, Colón-Ramos DA, Samuel AD, Zhang Y: Dynamic encoding of perception, memory, and movement in a C. elegans chemotaxis circuit. Neuron. 2014 Jun 4. PMID: 24908490 Christensen R, Shao Z, Colón-Ramos DA: The cell biology of synaptic specificity during development. Curr Opin Neurobiol. 2013 Dec; 2013 Aug 6. PMID: 23932598 Guerrero-Medina G, Feliú-Mójer M, González-Espada W, Díaz-Muñoz G, López M, Díaz-Muñoz SL, Fortis-Santiago Y, Flores-Otero J, Craig D, Colón-Ramos DA: Supporting diversity in science through social networking. PLoS Biol. 2013 Dec; 2013 Dec 31. PMID: 24391467 Shao Z, Watanabe S, Christensen R, Jorgensen EM, Colón-Ramos DA: Synapse location during growth depends on glia location. Cell. 2013 Jul 18. PMID: 23870123