Carroll, Topher - Yale University

个人简介

The eukaryotic genome is highly organized within the nucleus. This organization occurs at several different spatial scales, ranging from local interactions between proximal nucleosomes to the global positioning of large chromosomal domains within specific nuclear compartments. The Carroll lab is interested in understanding the molecular mechanisms that that control nuclear organization, and further, how these mechanisms are integrated to ensure the integrity and proper expression of the genome. We take an interdisciplinary approach using biochemistry, cell biology, genomics, and proteomics to address these questions. I first became interested in chromosome structure and dynamics as a graduate student in Dr. David Morgan's lab at UCSF where I studied the molecular mechanisms that control chromosome segregation during mitosis. I then moved to Stanford University School of Medicine to do a postdoc for Dr. Aaron Straight. As a postdoc, I developed biochemical and cell biological methods to dissect how the specialized chromatin environment of the centromere directs kinetochore assembly during mitosis. It was during this time that I became interested in understanding how specific regions of chromosomes are specialized for particular functions, and in particular, how the spatial organization of the genome influences these decisions. PhD University of California-San Francisco (2005) BS University of California at Santa Cruz (1997) Postdoctoral Fellow Stanford School of Medicine

研究领域

Biochemistry; Biology

近期论文

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Dynamics of CENP-N kinetochore binding during the cell cycle. Dynamics of CENP-N kinetochore binding during the cell cycle. Hellwig D, Emmerth S, Ulbricht T, Döring V, Hoischen C, Martin R, Samora CP, McAinsh AD, Carroll CW, Straight AF, Meraldi P, Diekmann S. J Cell Sci. 2011 Nov 15;124(Pt 22):3871-83 In vitro centromere and kinetochore assembly on defined chromatin templates. In vitro centromere and kinetochore assembly on defined chromatin templates. Guse A, Carroll CW, Moree B, Fuller CJ, Straight AF. Nature. 2011 Aug 28;477(7364):354-8 Dual recognition of CENP-A nucleosomes is required for centromere assembly. Dual recognition of CENP-A nucleosomes is required for centromere assembly. Carroll CW, Milks KJ, Straight AF. J Cell Biol. 2010 Jun 28;189(7):1143-55 Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. Carroll CW, Silva MC, Godek KM, Jansen LE, Straight AF. Nat Cell Biol. 2009 Jul;11(7):896-902 Protein architecture of the human kinetochore microtubule attachment site. Protein architecture of the human kinetochore microtubule attachment site. Wan X, O'Quinn RP, Pierce HL, Joglekar AP, Gall WE, DeLuca JG, Carroll CW, Liu ST, Yen TJ, McEwen BF, Stukenberg PT, Desai A, Salmon ED. Cell. 2009 May 15;137(4):672-84 An architectural map of the anaphase-promoting complex. An architectural map of the anaphase-promoting complex. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. Genes Dev. 2006 Feb 15;20(4):449-60 Centromere formation: from epigenetics to self-assembly. Centromere formation: from epigenetics to self-assembly. Carroll CW, Straight AF. Trends Cell Biol. 2006 Feb;16(2):70-8 Enzymology of the anaphase-promoting complex. Enzymology of the anaphase-promoting complex. Carroll CW, Morgan DO. Methods Enzymol. 2005;398:219-30 The APC subunit Doc1 promotes recognition of the substrate destruction box. The APC subunit Doc1 promotes recognition of the substrate destruction box. Carroll CW, Enquist-Newman M, Morgan DO. Curr Biol. 2005 Jan 11;15(1):11-8 The Doc1 subunit is a processivity factor for the anaphase-promoting complex. The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Carroll CW, Morgan DO. Nat Cell Biol. 2002 Nov;4(11):880-7 The septins are required for the mitosis-specific activation of the Gin4 kinase. The septins are required for the mitosis-specific activation of the Gin4 kinase. Carroll CW, Altman R, Schieltz D, Yates JR, Kellogg D. J Cell Biol. 1998 Nov 2;143(3):709-17