Bogan, Jonathan S - Yale University

个人简介

MD Harvard Medical School (1992) BS Yale University (1986) Visiting Scientist Whitehead Institute for Biomedical Research Fellow Massachusetts General Hospital Resident Massachusetts General Hospital Board Certification AB of Internal Medicine, Internal Medicine (1995, recertified: 2007) Board Certification AB of Internal Medicine, Endocrinology, Diabetes & Metabolism (1997, recertified: 2008)

研究领域

Cell Biology; Diabetes Mellitus, Type 2; Endocrinology; Glucose; Metabolic Diseases; Protein Transport

近期论文

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Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action. Xu Y, Nan D, Fan J, Bogan JS, Toomre D. Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action. Journal of Cell Science 2016;129:2085-95. Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle. Habtemichael EN, Alcázar-Román A, Rubin BR, Grossi LR, Belman JP, Julca O, Löffler MG, Li H, Chi NW, Samuel VT, and Bogan JS. Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle. Journal of Biological Chemistry 2015; 290:14454–14461. Acetylation of TUG Protein Promotes the Accumulation of GLUT4 Glucose Transporters in an Insulin-Responsive Intracellular Compartment. Belman JP, Bian RR, Habtemichael EN, Li DT, Jurczak MJ, Alcázar-Román A, McNally LJ, Shulman GI, and Bogan JS. Acetylation of TUG Protein Promotes the Accumulation of GLUT4 Glucose Transporters in an Insulin-Responsive Intracellular Compartment. Journal of Biological Chemistry 2015; 290:4447–4463. A proteolytic pathway that controls glucose uptake in fat and muscle. Belman JP, Habtemichael EN, and Bogan JS. A proteolytic pathway that controls glucose uptake in fat and muscle. Reviews in Endocrine and Metabolic Disorders 2014; 15:55–66. Enhanced Fasting Glucose Turnover in Mice with Disrupted Action of TUG Protein in Skeletal Muscle. Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee H-Y, Cartee GD, Philbrick W, Shulman GI, Samuel VT, and Bogan JS. Enhanced Fasting Glucose Turnover in Mice with Disrupted Action of TUG Protein in Skeletal Muscle. Journal of Biological Chemistry 2013; 288:20135–20150. Endoproteolytic Cleavage of TUG Protein Regulates GLUT4 Glucose Transporter Translocation. Bogan JS, Rubin BR, Yu C, Löffler MG, Orme CM, Belman JP, McNally LJ, Hao M, and Cresswell JC. Endoproteolytic Cleavage of TUG Protein Regulates GLUT4 Glucose Transporter Translocation. Journal of Biological Chemistry 2012; 287:23932-23947. Regulation of Glucose Transporter Translocation in Health and Diabetes. Bogan JS. Regulation of Glucose Transporter Translocation in Health and Diabetes. Annual Review of Biochemistry 2012; 81:507–32. The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum–Golgi Intermediate Compartment. Orme CM and Bogan JS. The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum–Golgi Intermediate Compartment. Journal of Biological Chemistry 2012; 287:6679-6692. Dual-Mode of Insulin Action Controls GLUT4 Vesicle Exocytosis. Xu Y, Rubin BR, Orme CM, Karpikov A, Yu C, Bogan JS*, and Toomre D* (*equal contribution; co-corresponding authors). Dual-Mode of Insulin Action Controls GLUT4 Vesicle Exocytosis. Journal of Cell Biology 2011; 193:643–653.