Wilson, Corey J - Yale University - Department of Chemical & Environmental Engineering

个人简介

Ph.D., Rice University

研究领域

The overarching goal of the research conducted in the Wilson Research Group is to establish an integrated experimental and computational framework to translate our understanding of the fundamental principles of biophysics and biochemistry (i.e., the physicochemical properties that confer function) into useful processes, devices, therapies, and diagnostics that will benefit society. To accomplish this the Wilson Research Group focuses on two principle Protein Engineering approaches: (i) computational protein design and (ii) optimized strategies in protein evolution. This research program is an integrated multidisciplinary initiative that includes applied mathematics, computer science, physical chemistry, experimental protein chemistry, biochemistry, cell biology, and molecular biophysics. In turn, our ability to engineer biological materials is a rigorous test of our understanding of the structure-function relationship—on multiple time and length scales. Accordingly, this research platform holds the promise of expanding our general knowledge with regard to protein folding, molecular interactions, signal transduction and enzyme-catalyzed reactions. Projects in the Wilson Research Group include: The rational design of temperature-adapted enzyme function. Engineering resistances to oxidative decay of protein structure and function. Rational design of energy transduction protein systems. Engineer higher-order biosensors and alternate allosteric communication. Development of Next-Generation, Ultra-selective Aquaporin-based Membranes for Water Purification.

近期论文

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Leveraging Rational Design and Detailed Structural Analysis to Elucidate the Mechanism of Oxidative Decay in Adenylate Kinase. Howell, S. C., Mitch, W. A., Richards, D.H. and Wilson, C. J. [in press] (2015) ACS Chemical Biology. PMID: 2626683 Rational Protein Design: Developing Next Generation Biological Therapeutics and Nanobiotechnological Tools. Wilson, C.J. (2015) WIREs Nanomedicine & Nanobiotechnology. 7(3):330-41 PMID: 25348497 Examining Photoinduced Energy Transfer in Pseudomonas aeruginosa Azurin. Tobin, P and Wilson, C.J. (2014) Journal of American Chemical Society. 136(5):1793-802. PMID: 24467236 Understanding thermal adaptation of enzymes through the multistate rational design and stability prediction of 100 adenylate kinases. Howell, S.C., Inampudiand, K.K., Bean, D.P. and Wilson, C.J. (2014) Structure. 4;22(2):218-29. PMID: 24361272 Engineering alternate cooperative-communications in the lactose repressor protein scaffold, Protein engineering, design & selection. Meyer, S., Ramot, R., Kishore Inampudi, K., Luo, B., Lin, C., Amere, S., and Wilson, C. J. (2013) Protein Engineering Design & Selection 26, 433-443. PMID: 23587523 Role of lysine during protein modification by HOCl and HOBr: halogen-transfer agent or sacrificial antioxidant? Sivey, J. D., Howell, S. C., Bean, D. J., McCurry, D. L., Mitch, W. A., and Wilson, C. J. (2013) Biochemistry 52, 1260-1271. PMID: 23327477