Humphrey, Jay - Yale University - Biomedical Engineering

研究领域

Vascular Mechanics and Mechanobiology: using genetic, pharmacologic, and surgical models to elucidate mechanisms that underlie diverse vascular diseases; developing theoretical frameworks for understanding vascular disease progression and designing clinical interventions; and using computational models to design and evaluate tissue engineered vascular grafts based on concepts of mechanobiology and immunobiology.

近期论文

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Roccabianca S, Ateshian G, Humphrey JD (2014) Biomechanical roles of medial pooling of glycosaminoglycans in thoracic aortic dissection. Biomech Model Mechanobiol 13: 13-25. Humphrey JD, Milewicz DM, Tellides G, Schwartz MA (2014) Dysfunctional mechanosensing in aneurysms. Science 344: 477-479. Cyron C, Humphrey JD (2014) Vascular homeostasis and the concept of mechanobiological stability. Int J Engr Sci 85: 203-223. Humphrey JD, Dufrense E, Schwartz MA (2014) Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 15: 802-812. Miller KS, Khosravi R, Breuer CK, Humphrey JD (2015) A hypothesis-driven parametric study of the effects of polymeric scaffold properties on tissue engineered neovessel formation. Acta Biomater 11: 283-294. Bellini C, Wang S, Milewicz DM, Humphrey JD (2015) Myh11R247C/R247C mutations increase thoracic aortic vulnerability to intramural damage despite a general biomechanical adaptivity. J Biomech 48: 113-121. Bersi MR, Bellini C, Wu J, Harrison DG, Humphrey JD (2016) Excessive adventitial remodeling leads to early aortic maladaptation in angiotensin-induced hypertension. Hypertension 67: 890-896. Humphrey JD, Harrison DG, Figueroa CA, Lacolley P, Laurent S (2016) Central artery stiffness in hypertension and aging: A problem with cause and consequence. Circ Res 118: 379-381.