Gonzalez, Anjelica - Yale University - Biomedical Engineering

研究领域

Anjelica Gonzalez’ appointment in Biomedical Engineering in association with the Vascular Biology and Therapeutics Program has provided a supportive and convenient platform for her research, focused on the development of biomaterials for use as investigational tools, particularly for the investigation of immunological responses to inflammatory signals from endogenous and exogenous sources. Gonzalez has a dedicated interest in training the next generation of scientists to think interdisciplinary and approach problems form a scientifically global perspective. With a mutli-disciplinary approach, the Gonzalez lab combines organic chemistry, molecular biology, mathematics, computational modeling and image analysis to develop and use biomedically engineering scaffolds to dissect the chemo-mechanics of immunological processes. This work has special significance to an array of diseases and disorders, including atherosclerosis, arthritis, diabetes, cutaneous T-cell lymphoma, and sepsis. Research projects in the Gonzalez lab include the development of biomaterials for investigating the influence of outside-in mediated signaling through adhesion molecules on cellular architecture and subsequent signaling pathways. These activities are investigated in neutrophils, leukocytes and pericytes. Additionally, in collaboration with Yale School of Medicine Dept. of Dermatology, Dr .Gonzalez is elucidating the mechanism of the cutaneous T-cell lymphoma treatment known as transimmunization therapy. This treatment, in which cells are extracted, treated with drugs, and then reintroduced into the patient, is effective, though poorly understood. Research in the Gonzalez lab has made headway toward understanding signaling pathways driving monocytes down the dentritic cell lineage.

近期论文

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Ayres-Sander CE, Lauridsen H, Maier CL, Sava P, Pober JS, and Gonzalez AL. Transendothelial Migration Enables Subsequent Transmigration of Neutrophils through Underlying Pericytes. PLoS One. 2013; 8:e60025. PMCID: PMC3608600. Lauridsen H and Gonzalez AL. Role of pericytes in tissue engineering. Vascularization: Regenerative Medicine and Tissue Engineering. CRC Press; 2013 (in press). Pu KM, Sava P and AL Gonzalez. Microvascular Targets in Fibrosis. YJBM, 2013 Dec;86(4):537-554. PMCID: 24348218. Lauridsen H, Pober JS, Gonzalez AL. A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment. FASEB J. 2013 Dec 2. PMID: 24297702. Gonzalez AL, Berger CE, Remington J, Girardi M, Tigelaar RE, Edelson, R. Integrin Driven Monocyte to Dendritic Cell Conversion in Modified Extracorporeal Photochemotherapy. Clin Exp Immunol. 2013 Nov 5. doi: 10.1111/cei.12231. PMID: 24188174. Huang RB, Gonzalez AL and Eniola-Adefeso E. Laminar Shear Stress Elicit Distinct Endothelial Cell E-Selectin Expression Induced via TNFα and IL-1β. Biotech Bioeng. 2012 Oct 10. doi: 10.1002/bit.24746. Lee SW, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JW, Seol JK, Sander C, Gonzalez AL, Li J, and Fan R. Nanowire Substrate-Based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells. Nano Lett. 2012, 12, 2697−2704. Padmanabhan J and Gonzalez AL. Investigation Of The Effects Of Extracellular Matrix Proteins On Neutrophil-Endothelial Interaction – A Roadway To Multiple Therapeutic Opportunities. YJBM, 2012 Jun;85(2):167-85. Epub 2012 Jun 25. Ayers-Sander CE and Gonzalez AL. Approaches in extracellular matrix engineering for determination of adhesion molecule mediated single cell function. Frontiers in Biology. December 2012, DOI: 10.1007/s11515-012-1199-x Katz DL, Green LW, Murimi M, Gonzalez AL, Njike VY. The mTCT & CBPR: A Failure to Communicate? Am J Public Health. Sept 2011. Katz DL, Murimi M, Gonzalez AL, Njike V, Green LW. From controlled trial to community adoption: The multisite translational community trial. Am J Public Health. 101(8):e17-27. Aug 2011. Gonzalez-Simon AL and Eniola-Adefeso O. Host response to biomaterials. Engineering Biomaterials for Regenerative Medicine Novel Technologies for Clinical Applications. 1st Edition., XIV, 400 p. 76. Nov 2011. Gonzalez AL, El-Bjeirami W, West JL, McIntire LV, Smith CW: Transendothelial migration enhances integrin dependent human neutrophil chemokinesis. Journal of Leukocyte Biology. Volume 81, Issue 3, Pg.686-95 2007. Njike V, Faridi Z, Dutta S, Gonzalez-Simon AL, and Katz DL. Daily egg consumption in hyperlipidemic adults -Effects on endothelial function and cardiovascular risk. Nutr. J. Vol 9, Pg 28. Jul 2010. Gonzalez AL, Gobin AS, West JL, McIntire LV, Smith CW: Integrin Interactions with Immobilized Peptides in Polyethylene Glycol Diacrylate Hydrogels. Tissue Engineering. Nov-Dec;10(11-12):1775-86. 2004.