Fan, Rong - Yale University - Biomedical Engineering

研究领域

Dr. Fan's research is focused on combining single-cell analysis technology and systems biology to study cell-cell communication and cellular heterogeneity in human cancers and the immune system. In particular, his laboratory developed a microchip platform for highly multiplexed protein measurement in single cells and a microfluidic processor to facilitate genomic, epigenetic, and transcriptional profiling at the single-cell level. The end goal was to accelerate the translational development of these technology platforms to clinical tools for informative immune monitoring or cancer diagnosis.

近期论文

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Xue Q, Lu Y, Eisele MR, Sulistijo E, Fan R*, and Miller-Jensen K*, Analysis of single-cell secretion reveals a role for paracrine signaling in coordinating macrophage response to TLR4 stimulation, Science Signaling, 8, 381 (2015). Lu Y, Xue Q, Eisele MR, Sulistijo E, Brower K, Han L, Amir ED, Pe'er D, Miller-Jensen K *, and Fan R*, Highly multiplexed profiling of immune effector functions reveals deep functional heterogeneity in response to pathogenic ligands, Proc. Natl. Acad. Sci., U.S.A., 112(7), 607-615 (2015). Kleppe M, Kwak M, Koppikar P, Riester M, Keller M, Bastian L, Hricik T, Bhagwat N, Abdel-Wahab OI, Marubayashi S, Chen JJ, Romanet V, Fridman JS, Bromberg J, Murakami M, Radimerski T, Michor F, Fan R*, and Levine RL*. JAK-STAT Pathway Activation in Malignant and Non-Malignant Cells Contributes to MPN Pathogenesis and Therapeutic Response, Cancer Discovery, 5(3), 316–31 (2015). Han L, Zi XY, Garmire LX, Wu Y, Weissman SM, Pan XH, and Fan R, Co-detection and sequencing of genes and transcripts from the same single cells facilitated by a microfluidics platform, Scientific Reports, 4, 6485 (2014). Kwak M, Kim DJ, Han L, Lee MR, Wu Y, Lee SK, and Fan R. Nanowire array chips for molecular typing of rare trafficking leukocytes with application to neurodegenerative pathology, Nanoscale, 6(12), 6537-50 (2014). (cover highlight) Lu Y, Chen JJ, Mu L, Xue Q, Wu Y, Wu PH, Li J, Vortmeyer AO, Miller-Jensen K, Wirtz D, and Fan R, High-throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity, Analytical Chemistry, 85 (4), 2548–2556, (2013). Lee SK, Kim, GS, Wu Y, Lu Y, Han L, Kim DJ, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J & Fan R, Nanowire Substrate-based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells, Nano Letters, 12(6), 2697-2704 (2012)