个人简介
Dr. Yong Zhu is an Associate Professor at Yale University School of Public Health and Assistant Director of Yale Cancer Center for Global Cancer Epidemiology. Dr. Zhu's research interests are oriented towards the use of the molecular epidemiological approach in the study of genetic susceptibility biomarkers and their interactions with environmental exposures in human disease development. Dr. Zhu has been developing and validating novel phenotypic and genotypic assays and biomarkers for several cancer types, including non-Hodgkin's Lymphoma, breast, bladder, lung and prostate cancer. By utilizing various techniques in genetics, epigenetics, cytogenetics, cell biology, and computational biology, his studies have identified biomarkers that can characterize inherited predisposition and cellular response to environmental factors. Current research focuses on studying the role of two transcriptional factors, circadian genes and small noncoding RNAs, in tumorigenesis.
PhD Rice University (2000)
MA Rice University (1998)
Postdoctoral Fellow MD Anderson Cancer Center
近期论文
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Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women
Zhu, Y., Brown, H., Zhang, Y., Stevens, R.G., and Zheng, T. Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women. Cancer Epidemiology, Biomarkers & Prevention 14(1): 268-70, 2005.
An Evolutionary Perspective on SNP Screening in Molecular Cancer Epidemiology
Zhu, Y., Spitz, M.R., Amos, C.I., Lin, J., Schabath, M.B., and Wu, X. An Evolutionary Perspective on SNP Screening in Molecular Cancer Epidemiology. Cancer Research 64: 2251-2257, 2004
Does “Clock” Matter in Prostate Cancer?
Zhu, Y., Zheng, T., Zhang, Y., Stevens, R., and Boyle, P. Does “Clock” Matter in Prostate Cancer? Cancer Epidemiology, Biomarkers & Prevention 15(1): 3-5, 2006.
MicroRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis
Hoffman A, Zheng T, Yi CH, Weidhaas J, Slack F, Zhang Y, Leaderer D, Zhu Y. MicroRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis. Cancer Research July 15;69 (14), 2009, PMID: 19567675
Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis
Yi CH, Zheng T, Leaderer D, Hoffman A, Zhu Y. Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis. Cancer Letter May 18, 2009, PMID: 19457610
Clock-cancer connection in Non-Hodgkin’s Lymphoma: a genetic association study and pathway analysis of the circadian gene Cryptochrome 2
Hoffman A, Zheng T, Stevens RG, Ba Y, Zhang Y, Leaderer D, Yi CH, Holford TR, Zhu Y. Clock-cancer connection in Non-Hodgkin’s Lymphoma: a genetic association study and pathway analysis of the circadian gene Cryptochrome 2. Cancer Research Apr 15;69(8):3605-13, 2009, PMID: 19318546
Huang H, Zhu Y, Eliot MN, Knopik VS, McGeary JE, Carskadon MA, Hart AC: Combining Human Epigenetics and Sleep Studies in C. elegans: A Cross-species Approach for Finding Conserved Genes Regulating Sleep. Sleep. 2017 Apr 18; 2017 Apr 18. PMID: 28431118
Pietrzak RH, Zhu Y, Slade MD, Qi Q, Krystal JH, Southwick SM, Levy BR: Association Between Negative Age Stereotypes and Accelerated Cellular Aging: Evidence from Two Cohorts of Older Adults. J Am Geriatr Soc. 2016 Nov; 2016 Sep 19. PMID: 27641354
Jacobs DI, Qin Q, Lerro MC, Fu A, Dubrow R, Claus EB, DeWan AT, Wang G, Lin H, Zhu Y: PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses. Cancer Epidemiol Biomarkers Prev. 2016 Jul; 2016 May 13. PMID: 27197292
Pang J, Zhang Z, Zheng TZ, Bassig BA, Mao C, Liu X, Zhu Y, Shi K, Ge J, Yang YJ, Dejia-Huang, Bai M, Peng Y: Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis. Int J Cardiol. 2016 Jan 1; 2015 Jan 4. PMID: 26318390
Fu A, Jacobs DI, Hoffman AE, Zheng T, Zhu Y: PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome. Carcinogenesis. 2015 Oct; 2015 Jul 25. PMID: 26210741
Stevens RG, Zhu Y: Electric light, particularly at night, disrupts human circadian rhythmicity: is that a problem? Philos Trans R Soc Lond B Biol Sci. 2015 May 5. PMID: 25780233
Mao Y, Fu A, Hoffman AE, Jacobs DI, Jin M, Chen K, Zhu Y: The circadian gene CRY2 is associated with breast cancer aggressiveness possibly via epigenomic modifications. Tumour Biol. 2015 May; 2015 Mar 5. PMID: 25740058
Liu R, Jacobs DI, Hansen J, Fu A, Stevens RG, Zhu Y: Aberrant methylation of miR-34b is associated with long-term shiftwork: a potential mechanism for increased breast cancer susceptibility. Cancer Causes Control. 2015 Feb; 2014 Nov 15. PMID: 25398683
Guo H, Bassig BA, Lan Q, Zhu Y, Zhang Y, Holford TR, Leaderer B, Boyle P, Qin Q, Zhu C, Li N, Rothman N, Zheng T: Polymorphisms in DNA repair genes, hair dye use, and the risk of non-Hodgkin lymphoma. Cancer Causes Control. 2014 Oct; 2014 Sep 2. PMID: 25178586
Guo H, Jin Y, Cheng Y, Leaderer B, Lin S, Holford TR, Qiu J, Zhang Y, Shi K, Zhu Y, Niu J, Bassig BA, Xu S, Zhang B, Li Y, Hu X, Chen Q, Zheng T: Prenatal exposure to organochlorine pesticides and infant birth weight in China. Chemosphere. 2014 Sep; 2014 Apr 5. PMID: 24880592
Fu A, Hoffman AE, Liu R, Jacobs DI, Zheng T, Zhu Y: Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis. Epigenetics. 2014 May; 2014 Feb 6. PMID: 24503492
Fu A, Jacobs DI, Zhu Y: Epigenome-wide analysis of piRNAs in gene-specific DNA methylation. RNA Biol. 2014. PMID: 25590657
Mao Y, Fu A, Leaderer D, Zheng T, Chen K, Zhu Y: Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses. BMC Cancer. 2013 Oct 25; 2013 Oct 25. PMID: 24161199
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