Zhang, Yongli - Yale University - Biological & Biomedical Sciences

个人简介

PhD Yale School of Medicine (2003) MS Chinese Academy of Sciences, P.R.C. (1997)

研究领域

Biochemistry; Biophysics; Cell Biology; Membrane Fusion; Dynamins; Chromatin Assembly and Disassembly; SNARE Proteins; Optical Tweezers

近期论文

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DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC Zhang, Y.L., Smith, C.L., Saha, A., Grill, S.W., Mihardja, S., Smith, S.B., Cairns, B.R., Peterson, C.L., and Bustamantel, C. (2006). DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Mol. Cell 24, 559-568. Effect of force on mononucleosomal dynamics Mihardja, S., Spakowitz, A.J., Zhang, Y.L., and Bustamante, C. (2006). Effect of force on mononucleosomal dynamics. Proc. Natl. Acad. Sci. USA 103, 15871-15876. Statistical-mechanical theory of DNA looping Zhang, Y. L. , McEwen, A. E., Crothers, D. M. & Levene, S. D. (2006). Statistical-mechanical theory of DNA looping, Biophys. J. 90, 1913-1924. Predicting indirect readout effects in protein-DNA interactions Zhang, Y. L. , Xi, Z. Q., Hegde, R. S., Shakked, Z., & Crothers, D. M. (2004). Predicting indirect readout effects in protein-DNA interactions. Proc. Natl. Acad. Sci. USA. 101, 8337-8341. A high throughput approach for the detection of DNA bending and flexibility based on cyclization Zhang, Y. L. & Crothers, D. M. (2003). A high throughput approach for the detection of DNA bending and flexibility based on cyclization. Proc. Natl. Acad. Sci. USA. 100, 3161-3166. Statistical mechanics of sequence-dependent circular DNA and its application for DNA cyclization Zhang, Y. L. & Crothers, D. M. (2003). Statistical mechanics of sequence-dependent circular DNA and its application for DNA cyclization. Biophys. J. 84, 136-153. Zhang Y: Energetics, kinetics, and pathway of SNARE folding and assembly revealed by optical tweezers. Protein Sci. 2017 Jan 18; 2017 Jan 18. PMID: 28097727 Jiao J, Rebane AA, Ma L, Zhang Y: Single-Molecule Protein Folding Experiments Using High-Precision Optical Tweezers. Methods Mol Biol. 2017. PMID: 27844436 Zhang X, Rebane AA, Ma L, Li F, Jiao J, Qu H, Pincet F, Rothman JE, Zhang Y: Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complex. Proc Natl Acad Sci U S A. 2016 Dec 13; 2016 Nov 28. PMID: 27911771 Zhang Y, Jiao J, Rebane AA: Hidden Markov Modeling with Detailed Balance and Its Application to Single Protein Folding. Biophys J. 2016 Nov 15. PMID: 27851936 Clapier CR, Kasten MM, Parnell TJ, Viswanathan R, Szerlong H, Sirinakis G, Zhang Y, Cairns BR: Regulation of DNA Translocation Efficiency within the Chromatin Remodeler RSC/Sth1 Potentiates Nucleosome Sliding and Ejection. Mol Cell. 2016 May 5. PMID: 27153540 Ma L, Kang Y, Jiao J, Rebane AA, Cha HK, Xi Z, Qu H, Zhang Y: α-SNAP Enhances SNARE Zippering by Stabilizing the SNARE Four-Helix Bundle. Cell Rep. 2016 Apr 19; 2016 Apr 7. PMID: 27068468 Rebane AA, Ma L, Zhang Y: Structure-Based Derivation of Protein Folding Intermediates and Energies from Optical Tweezers. Biophys J. 2016 Jan 19. PMID: 26789767 Ma L, Rebane AA, Yang G, Xi Z, Kang Y, Gao Y, Zhang Y: Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. Elife. 2015 Dec 23; 2015 Dec 23. PMID: 26701912 Jiao J, Rebane AA, Ma L, Gao Y, Zhang Y: Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition. Proc Natl Acad Sci U S A. 2015 Jun 2; 2015 May 18. PMID: 26038562 Lin Y, Long JJ, Huang F, Duim WC, Kirschbaum S, Zhang Y, Schroeder LK, Rebane AA, Velasco MG, Virrueta A, Moonan DW, Jiao J, Hernandez SY, Zhang Y, Bewersdorf J: Quantifying and optimizing single-molecule switching nanoscopy at high speeds. PLoS One. 2015; 2015 May 26. PMID: 26011109 Zorman S, Rebane AA, Ma L, Yang G, Molski MA, Coleman J, Pincet F, Rothman JE, Zhang Y: Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins. Elife. 2014 Sep 1; 2014 Sep 1. PMID: 25180101 Zhang X, Ma L, Zhang Y: High-resolution optical tweezers for single-molecule manipulation. Yale J Biol Med. 2013 Sep; 2013 Sep 20. PMID: 24058311 Gao Y, Zorman S, Gundersen G, Xi Z, Ma L, Sirinakis G, Rothman JE, Zhang Y: Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science. 2012 Sep 14; 2012 Aug 16. PMID: 22903523