个人简介
Wendell Yarbrough, MD, MMHC is the Section Chief of Otolaryngology Department of Surgery, Director of the Head & Neck Disease Center at Smilow Cancer Hospital and Co-Director of the Molecular Virology Program in the Yale Cancer Center.
Dr. Yarbrough was a Morehead Scholar at the University of North Carolina at Chapel Hill where he also attended medical school and completed residency and fellowship. He joins Yale from Vanderbilt University where he was the Co-Leader of the Thoracic and Head and Neck Program at the Vanderbilt Ingram Cancer Center, as well as Professor of Otolaryngology and Cancer Biology.
Dr. Yarbrough has a longstanding clinical interest in head and neck cancers and research interests in head and neck cancer translational research as well as identification of tumor suppressors and their mechanism of action. Recently, Dr. Yarbrough's lab has focused on identification of molecular defects in subsets of head & neck and salivary cancers to serve as novel targets for therapy. Dr. Yarbrough's lab has expertise in cell and molecular biology and in modeling of tumors for pre-clinical testing. The ultimate goal of Dr. Yarbrough's lab work is to improve outcomes for patients with head & neck and salivary cancers through innovative and rational development of new therapies.
MMHC Vanderbilt University (2010)
MD University of North Carolina at Chapel Hill (1989)
AB University of North Carolina, Chemistry (1985)
Fellow University of North Carolina at Chapel Hill School of Medicine
Resident University of North Carolina at Chapel Hill School of Medicine
Internship University of North Carolina at Chapel Hill School of Medicine
Board Certification AB of Otolaryngology, Otolaryngology (1995)
近期论文
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Characterization of HPV and host genome interactions in primary head and neck cancers.
Characterization of HPV and host genome interactions in primary head and neck cancers. Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R; the Cancer Genome Atlas Network; the Cancer Genome Atlas Network. Proc Natl Acad Sci U S A. 2014 Oct 13. pii: 201416074. [Epub ahead of print]
Conclusions about human papillomavirus-related malignancies.
Conclusions about human papillomavirus-related malignancies. Yarbrough WG, Rosenthal E. Head Neck. 2014 Jun;36(6):826-7. doi: 10.1002/hed.23378. Epub 2013 Sep 2.
Bledsoe TJ, Park HS, Stahl JM, Yarbrough WG, Burtness BA, Decker RH, Husain ZA: Hypofractionated Radiotherapy for Patients with Early-Stage Glottic Cancer: Patterns of Care and Survival. J Natl Cancer Inst. 2017 Oct 1. PMID: 28521361
Hajek M, Sewell A, Kaech S, Burtness B, Yarbrough WG, Issaeva N: TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. Cancer. 2017 May 15; 2017 Mar 13. PMID: 28295222
Panaccione A, Zhang Y, Ryan M, Moskaluk CA, Anderson KS, Yarbrough WG, Ivanov SV: MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma. Stem Cell Res. 2017 May; 2017 May 5. PMID: 28500913
Wamsley JJ, Gary C, Biktasova A, Hajek M, Bellinger G, Virk R, Issaeva N, Yarbrough WG: Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner. Oncogenesis. 2017 Apr 10; 2017 Apr 10. PMID: 28394357
Fujiwara RJ, Judson BL, Yarbrough WG, Husain Z, Mehra S: Treatment delays in oral cavity squamous cell carcinoma and association with survival. Head Neck. 2017 Apr; 2017 Feb 25. PMID: 28236349
An Y, Park HS, Kelly JR, Stahl JM, Yarbrough WG, Burtness BA, Contessa JN, Decker RH, Koshy M, Husain ZA: The prognostic value of extranodal extension in human papillomavirus-associated oropharyngeal squamous cell carcinoma. Cancer. 2017 Mar 21; 2017 Mar 21. PMID: 28323338
Tan WJT, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV: Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxid Redox Signal. 2017 Mar 9; 2017 Mar 9. PMID: 28135838
Panaccione A, Zhang Y, Mi Y, Mitani Y, Yan G, Prasad ML, McDonald WH, El-Naggar AK, Yarbrough WG, Ivanov SV: Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma. Oral Oncol. 2017 Mar; 2017 Jan 9. PMID: 28249646
Lee NC, Kelly JR, Park HS, Yarbrough WG, Burtness BA, Husain ZA: The risk of level IB nodal involvement in oropharynx cancer: Guidance for submandibular gland sparing irradiation. Pract Radiat Oncol. 2017 Feb 16; 2017 Feb 16. PMID: 28356201
Panaccione A, Guo Y, Yarbrough WG, Ivanov SV: Expression Profiling of Clinical Specimens Supports the Existence of Neural Progenitor-Like Stem Cells in Basal Breast Cancers. Clin Breast Cancer. 2017 Jan 27; 2017 Jan 27. PMID: 28216417
Wamsley JJ, Issaeva N, An H, Lu X, Donehower LA, Yarbrough WG: LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Cell Cycle. 2017 Jan 17; 2016 Dec 27. PMID: 28027003
Kelly JR, Park HS, An Y, Contessa JN, Yarbrough WG, Burtness BA, Decker R, Husain Z: Comparison of Survival Outcomes Among Human Papillomavirus-Negative cT1-2 N1-2b Patients With Oropharyngeal Squamous Cell Cancer Treated With Upfront Surgery vs Definitive Chemoradiation Therapy: An Observational Study. JAMA Oncol. 2017 Jan 5; 2017 Jan 5. PMID: 28056116
Kuo P, Mehra S, Sosa JA, Roman SA, Husain ZA, Burtness BA, Tate JP, Yarbrough WG, Judson BL: Proposing prognostic thresholds for lymph node yield in clinically lymph node-negative and lymph node-positive cancers of the oral cavity. Cancer. 2016 Dec 1; 2016 Aug 1. PMID: 27479645
Gary C, Hajek M, Biktasova A, Bellinger G, Yarbrough WG, Issaeva N: Selective antitumor activity of roscovitine in head and neck cancer. Oncotarget. 2016 Jun 21. PMID: 27233076
Kuo P, Sosa JA, Burtness BA, Husain ZA, Mehra S, Roman SA, Yarbrough WG, Judson BL: Treatment trends and survival effects of chemotherapy for hypopharyngeal cancer: Analysis of the National Cancer Data Base. Cancer. 2016 Jun 15; 2016 Mar 28. PMID: 27019213
Panaccione A, Chang MT, Carbone BE, Guo Y, Moskaluk CA, Virk RK, Chiriboga L, Prasad ML, Judson B, Mehra S, Yarbrough WG, Ivanov SV: NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma. Clin Cancer Res. 2016 Apr 15. PMID: 27084744
Schwam ZG, Burtness B, Yarbrough WG, Mehra S, Husain Z, Judson BL: National treatment patterns in patients presenting with Stage IVC head and neck cancer: analysis of the National Cancer Database. Cancer Med. 2015 Dec; 2015 Oct 16. PMID: 26471244
Uzhachenko R, Shanker A, Yarbrough WG, Ivanova AV: Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity. Oncotarget. 2015 Aug 28. PMID: 26246474
Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D: Detection and genotype of high-risk human papillomavirus in fine-needle aspirates of patients with metastatic squamous cell carcinoma is helpful in determining tumor origin. Am J Clin Pathol. 2015 May. PMID: 25873503
Farmer RW, McCall L, Civantos FJ, Myers JN, Yarbrough WG, Murphy B, O'Leary M, Zitsch R, Siegel BA: Lymphatic drainage patterns in oral squamous cell carcinoma: findings of the ACOSOG Z0360 (Alliance) study. Otolaryngol Head Neck Surg. 2015 Apr; 2015 Mar 6. PMID: 25749001
Yazlovitskaya EM, Voziyan PA, Manavalan T, Yarbrough WG, Ivanova AV: Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice. Cell Death Dis. 2015 Feb 19; 2015 Feb 19. PMID: 25695605
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