Yang, Xiaoyong - Yale University - Biological & Biomedical Sciences

个人简介

PhD University of Alabama at Birmingham (2001) MS Peking University (1996) BS Nankai University (1993) Postdoctoral Fellow The Salk Institute

研究领域

Biochemistry; Circadian Rhythm; Diabetes Mellitus; Genetics; Molecular Biology; Neoplasms; Physiology; Signal Transduction; Genomics; Proteomics; Systems Biology

近期论文

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Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation. Xie Z., D. Zhang, D. Chung, Z. Tang, H. Huang, L. Dai, S. Qi, J. Li, G. Colak, Y. Chen, C. Xia, C. Peng, H. Ruan, M. Kirkey, D. Wang, L.M. Jensen, O.K. Kwon, S. Lee, S.D. Pletcher, M. Tan, D.B. Lombard, K.P. White, H. Zhao, J. Li, R.G. Roeder, X. Yang*, Y. Zhao*. Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation. Mol. Cell 2016, 62:194-206. (*Co-corresponding author) PMID: 27105115 O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. Ruan H.B., M.O. Dietrich, Z.W. Liu, M.R. Zimmer, M.D. Li, J.P. Singh, K. Zhang, R. Yin, J. Wu, T.L. Horvath, X. Yang. O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. Cell 2014, 159:306–17. O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Li M.D., H.B. Ruan, M.E. Hughes, J.S. Lee, J.P. Singh, S.P. Jones, M.N. Nitabach, X. Yang. O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 2013, 17:303–10. O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1alpha stability. Ruan H.B., X. Han, M.D. Li, J.P. Singh, K. Qian, S. Azarhoush, L. Zhao, A.M. Bennett, V.T. Samuel, J. Wu, J.R. Yates III, X. Yang. O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1alpha stability. Cell Metab. 2012, 16:226-37. A wheel of time: the circadian clock, nuclear receptors, and physiology. Yang X. A wheel of time: the circadian clock, nuclear receptors, and physiology. Genes & Dev. 2010, 24:741-7. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Yang X., P.P. Ongusaha, P.D. Miles, J.C. Havstad, F. Zhang, W.W. So, J.E. Kudlow, R.H. Michell, J.M. Olefsky, S.J. Field, R.M. Evans. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature 2008, 451:964-9. Nuclear receptor expression links the circadian clock to metabolism. Yang X., M. Downes, R.T. Yu, A.L. Bookout, W. He, M. Straume, D.J. Mangelsdorf, R.M. Evans. Nuclear receptor expression links the circadian clock to metabolism. Cell 2006, 126:801-10. Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. Yang X., F. Zhang, J.E. Kudlow. Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. Cell 2002, 110:69-80 Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes Perry R.J., J.P. Camporez, R. Kursawe, P.M. Titchenell, D. Zhang, C.J. Perry, M.J. Jurczak, M.S. Han, X.M. Zhang, H.B. Ruan, X. Yang, S. Caprio, S.M. Kaech, H.S. Sul, M.J. Birnbaum, R.J. Davis, G.W. Cline, K.F. Petersen, G.I. Shulman. Cell, 160:745-58. Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity Bindesbøll C., Q. Fan, R.C. Nørgaard, L. MacPherson, H.B. Ruan, J. Wu, T.A. Pedersen, K.R. Steffensen, X. Yang, J. Matthews, S. Mandrup, H.I. Nebb, L.M. Grønning-Wang. J. Lipid Res. 56:771-85. Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling Jiang M., Z. Qiu, S. Zhang, X. Fan, X. Cai, B. Xu, X. Li, J. Zhou, X. Zhang, Y. Chu, W. Wang, J. Liang, T. Horvath, X. Yang, K. Wu, Y. Nie, D. Fan. Oncotarget. 7:61390-402. PMC Journal – In Process Hepatic inositol 1,4,5 trisphosphate receptor type i mediates fatty liver 27. Feriod C.N., A.G. Oliveira, M.T. Guerra, L. Nguyen, K.M. Richards, M.J. Jurczak, H.B. Ruan, J.P. Camporez, X. Yang, G.I. Shulman, A.M. Bennett, M.H. Nathanson, B.E. Ehrlich. Hepatology Commun. doi:10.1002/hep4.1012.