Yan, Qin - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Qin Yan （严钦) is an Associate Professor of Pathology at Yale Medical School and a member of Yale Comprehensive Cancer Center and Yale Stem Cell Center. He directs a research laboratory to elucidate the roles of epigenetic mechanisms that drive tumor initiation and progression and to translate the findings to the clinic. His laboratory has made significant contributions to the understanding of H3K4me3/2 histone demethylases. Dr. Yan received his B.S. degree from the University of Science and Technology of China. After his Ph.D. training on regulation of transcription and ubiquitination with Drs. Joan and Ronald Conaway at the Oklahoma Medical Research Foundation and Stowers Institute for Medical Research, he completed his postdoctoral training on cancer biology with HHMI Investigator Dr. William Kaelin at the Dana-Farber Cancer Institute and Harvard Medical School. He has received numerous awards including Era of Hope Scholar Award from Dod Breast Cancer Research Program, Stewart Scholar Award and V Scholar Award. PhD University of Oklahoma College of Medicine (2002) MS University of Oklahoma College of Medicine (1998) BS University of Science and Technology of China, Molecular Biology (1996) Postdoctoral Associate Dana-Farber Cancer Institute and Howard Hughes Medical Institute

研究领域

Gene Expression Regulation; Neoplasm Metastasis; Neoplasms; Stem Cells; Neoplastic Stem Cells; Histone Demethylases; Epigenomics

近期论文

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KDM5 Lysine Demethylases Are Involved in Maintenance of 3'UTR Length Blair LP, Liu Z, Labitigan RL, Wu L, Zheng D, Xia Z, Pearson EL, Nazeer FI, Cao J, Lang SM, Rines RJ, Mackintosh SJ, Moore CL, Li W, Tian B, Tackett AJ, Yan Q. Sci Adv; 2016, 2, e1501662. An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting. Cao J, Wu L, Zhang SM, Lu M, Cheung WK, Cai W, Gale M, Xu Q, Yan Q. An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting. Nucleic Acids Res. 2016, 44(19):e149 Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JS, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q#, Cheng X#. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol. 2016;23:769-81 # co-corresponding authors Histone demethylase RBP2 is critical for breast cancer progression and metastasis Cao J, Liu Z, Cheung WKC, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q. Histone demethylase RBP2 is critical for breast cancer progression and metastasis, Cell Reports, 2014; 6(5):868-77 Histone Demethylases Set the Stage for Cancer Metastasis. Cao J and Yan Q. Histone Demethylases Set the Stage for Cancer Metastasis. Science Signaling. 2013; 6:pe15. Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen. Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel J, Yan Q. Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen. J Biol Chem. 2013 Mar 29;288(13):9408-17. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG Jr, Yan Q. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011;108:13379-86. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Klose RJ*, Yan Q*, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell. 2007; 128:889-900 *equal contribution Brier AB, Loft A, Madsen JGS, Rosengren T, Nielsen R, Schmidt SF, Liu Z, Yan Q, Gronemeyer H, Mandrup S: The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation. Nucleic Acids Res. 2017 Feb 28. PMID: 27899593 Blair LP, Liu Z, Labitigan RL, Wu L, Zheng D, Xia Z, Pearson EL, Nazeer FI, Cao J, Lang SM, Rines RJ, Mackintosh SG, Moore CL, Li W, Tian B, Tackett AJ, Yan Q: KDM5 lysine demethylases are involved in maintenance of 3'UTR length. Sci Adv. 2016 Nov; 2016 Nov 18. PMID: 28138513 Lizardi PM, Yan Q, Wajapeyee N: DNA Bisulfite Sequencing for Single-Nucleotide-Resolution DNA Methylation Detection. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852843 Lizardi PM, Yan Q, Wajapeyee N: High-Throughput Deep Sequencing for Mapping Mammalian DNA Methylation. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852842 Lizardi PM, Yan Q, Wajapeyee N: Illumina Sequencing of Bisulfite-Converted DNA Libraries. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852841 Lizardi PM, Yan Q, Wajapeyee N: Methyl-Cytosine-Based Immunoprecipitation for DNA Methylation Analysis. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852840 Lizardi PM, Yan Q, Wajapeyee N: Analysis of DNA Methylation in Mammalian Cells. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852839 Lizardi PM, Yan Q, Wajapeyee N: Methylation-Specific Polymerase Chain Reaction (PCR) for Gene-Specific DNA Methylation Detection. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852838 Cao J, Wu L, Zhang SM, Lu M, Cheung WK, Cai W, Gale M, Xu Q, Yan Q: An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting. Nucleic Acids Res. 2016 Nov 2; 2016 Jul 25. PMID: 27458201