Yan, Elsa - Yale University - Biological & Biomedical Sciences

个人简介

Elsa Yan was born and grew up in Hong Kong. She graduated from the Chinese University of Hong Kong in 1995. Working with Kenneth Eisenthal on nonlinear optics and surface sciences, she obtained her Ph.D. at Columbia University in 2000. From 2000-2004, she was a postdoctoral fellow in Richard Mathies's lab at UC Berkeley and a visiting fellow in Thomas Sakmar's lab at the Rockefeller University. She combined Raman spectroscopy with techniques in molecular biology to understand the molecular mechanism of signal transduction in the G-protein coupled receptor rhodopsin. In 2004, she joined The Rockefeller University, where she continued to develop methods in expression and purification of membrane proteins. In 2007, Elsa became an Assistant Professor of Chemistry at Yale. She was promoted to Associate Professor of Chemistry in 2012. PhD Columbia University, Chemistry (2000) BS Chinese University of Hong Kong, Chemistry (1996) Postdoctoral Fellow Rockefeller University Postdoctoral Fellow University of California, Berkeley

研究领域

Amino Acids, Peptides, and Proteins; Eye Diseases; Hormones, Hormone Substitutes, and Hormone Antagonists; Chemical Actions and Uses; Macromolecular Substances

近期论文

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Liu, M.Y.; Liu, J.; Mehrotra, D.; Liu, Y.; Guo, Y.; Baldera-Aguayo, P.A.; Mooney, V; Nour, A.M.; Yan, E.C.Y. “Thermal Stability of Rhodopsin and Progression of Retinitis Pigmentosa: A Comparison of S186W and D190N Rhodopsin Mutants” In press, J. Biol. Chem. 2013 Fu, L.; Xiao, D.Q.; Wang, Z.; Batista, V. S.; Yan, E.C.Y. “Chiral Sum Frequency Generation for Probing the Hydrogen/Deuterium Exchange in Antiparallel beta-Sheet Peptides at Interfaces” J. Am. Chem. Soc. 135, 3592, 2013 Mitra, N.; Liu, Y.; Liu, J.; Serebryany, E.; Mooney, V.; DeVree, B.T.; Sunahara, R.; Yan, E.C.Y. “Calcium Dependent Ligand Binding and G-protein Signaling of Family B GPCR Parathyroid Hormone 1 Receptor Purified in Nanodiscs” ACS Chem. Biol. 8, 617, 2013 Fu, L.; Liu, J.; Yan, E.C.Y. “Chiral Sum Frequency Generation for Identification of Protein Secondary Structures at Interfaces” J. Am. Chem. Soc. 133, 8094, 2011 Fu, L.; Ma, G.; Yan, E.C.Y. “In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Sum Frequency Generation Spectroscopy” J. Am. Chem. Soc. 132, 5405, 2010 Serebryany, E.; Zhu, G.F.; Fu, L.; Liu, J.; Yan, E.C.Y. “Artificial Membrane-like Environments for In Vitro Studies of Purified G-protein Coupled Receptors” Invited Review, BBA-Biomembrane, 1818, 225, 2011