Xu, Tian - Yale University - Biological & Biomedical Sciences

个人简介

PhD Yale University (1990) BS Fudan University, Biology (1982) Helen H. Whitney Postdoctoral Fellow UC Berkeley

研究领域

Basement Membrane; Drosophila; Genetics; Metabolism; Neoplasm Metastasis; Genomics

近期论文

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Interaction between RasV12 and scribble clones induces tumor growth and invasion. Wu M, Pastor-Pareja JC & Xu T. Interaction between RasV12 and scribble clones induces tumor growth and invasion. Nature, 2010, 403, 676–680. Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Igaki T., Pastor-Pareja, JC., , Aonuma, H., Miura M. and Xu T. Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell, 2009, 16:458-465. Efficient Transposition of the piggyBac (PB) Transposon in Mammalian Cells and Mice. Ding S, Wu X, Li G, Han M, Zhuang Y, Xu T. (2005). Efficient Transposition of the piggyBac (PB) Transposon in Mammalian Cells and Mice. Cell 122(3):473-483. A genetic screen in Drosophila for metastatic behavior. Pagliarini, R.A. and Xu, T. (2003). A genetic screen in Drosophila for metastatic behavior. Science 14:1227-31. Drosophila Atrophin homolog functions as a transcriptional co-repressor in multiple developmental processes. Zhang S, Xu L, Lee J, Xu T. Drosophila Atrophin homolog functions as a transcriptional co-repressor in multiple developmental processes. Cell 2002, 108:45-56. Akt regulates growth by directly phosphorylating Tsc2. Potter CJ, Pedraza LG,Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nature Cell Biol 2002,4:658-665. Potter C J, Huang H, Xu T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 2001, 105:357-368. Li G, Ye Z, Shi C, Sun L, Han M, Zhuang Y, Xu T, Zhao S, Wu X: The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. Sci Rep. 2017 Apr 4; 2017 Apr 4. PMID: 28374742 Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Mandelkern T, Zheng M, Xu T, Rothberg J, Lichenstein H: Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. Blood. 2017 Mar 30; 2017 Jan 19. PMID: 28104689 Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Xu T, Rothberg J, Lichenstein H: B-cell non-Hodgkin lymphoma: Selective vulnerability to PIKFYVE inhibition. Autophagy. 2017 Mar 28; 2017 Mar 28. PMID: 28350209 Chabu C, Li DM, Xu T: EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth. Nat Commun. 2017 Mar 10; 2017 Mar 10. PMID: 28281543 Yang D, Liao R, Zheng Y, Sun L, Xu T: Analysis of PBase Binding Profile Indicates an Insertion Target Selection Mechanism Dependent on TTAA, But Not Transcriptional Activity. Int J Biol Sci. 2016; 2016 Jul 18. PMID: 27570481 Wang G, Li R, Yang Y, Cai L, Ding S, Xu T, Han M, Wu X: Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice. Cell Biosci. 2016; 2016 Jun 10. PMID: 27293546 Ye Z, Sun L, Li R, Han M, Zhuang Y, Wu X, Xu T: Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy. Int J Biol Sci. 2016; 2016 Jun 7. PMID: 27489495 Li S, Mo K, Tian H, Chu C, Sun S, Tian L, Ding S, Li TR, Wu X, Liu F, Zhang Z, Xu T, Sun LV: Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy. Cell Biosci. 2016; 2016 Jun 4. PMID: 27274810 Liu Y, Li TR, Xu C, Xu T: Ribose Accelerates Gut Motility and Suppresses Mouse Body Weight Gaining. Int J Biol Sci. 2016; 2016 Apr 28. PMID: 27194947 Willsey HR, Zheng X, Carlos Pastor-Pareja J, Willsey AJ, Beachy PA, Xu T: Localized JNK signaling regulates organ size during development. Elife. 2016 Mar 14; 2016 Mar 14. PMID: 26974344 Tian L, Ding S, You Y, Li TR, Liu Y, Wu X, Sun L, Xu T: Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy. Dis Model Mech. 2015 Jun; 2015 Apr 16. PMID: 26035871 Gayle S, Pan Y, Landrette S, Xu T: piggyBac insertional mutagenesis screen identifies a role for nuclear RHOA in human ES cell differentiation. Stem Cell Reports. 2015 May 12; 2015 Apr 9. PMID: 25866159