Xiong, Yong - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Xiong’s research focuses on structural and biochemical studies of HIV suppression by host antiviral factors and viral immune evasion. PhD Ohio State University (2000) MS Ohio State University (1999) Postdoctoral Fellow Yale University

近期论文

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Structure of a Prokaryotic Virtual Proton Pump at 3.2 Å Resolution Fang, Y., Jayaram, H., Shane, T., Kolmakova-Partensky, L., Wu, F., Williams, C., Xiong. Y. & Miller. C. (2009). Structure of a Prokaryotic Virtual Proton Pump at 3.2 Å Resolution. Nature 460, 1040-1043. A cytidine deaminase edits tRNAs in archaea Randau, L*†, Stanley, B*, Kohlway, A., Mechta, S., Xiong, Y.† and Söll, D.† (2009) A cytidine deaminase edits tRNAs in archaea. Science 324, 657-659. (*: Equal contributions; †: Corresponding authors). The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together *Lomakin, I.B.,*#Xiong, Y., and #Steitz, T.A. (2007). The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell 129:319-332. (*equal contributions #corresponding authors). Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template Xiong, Y. and Steitz, T.A. (2004). Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template. Nature 430:640-645. Structure of a synaptic ?d resolvase tetramer covalently linked to two cleaved DNAs Li, W., Kamtekar, S., Xiong, Y., Grindley, N.D. and Steitz, T.A. Structure of a synaptic ?d resolvase tetramer covalently linked to two cleaved DNAs. Science 309, 1210-1215 (2005) Stoneham CA, Singh R, Jia X, Xiong Y, Guatelli J: Endocytic Activity of HIV-1 Vpu: Phosphoserine-dependent Interactions with Clathrin Adaptors. Traffic. 2017 May 14; 2017 May 14. PMID: 28504462 Reiss CW, Xiong Y, Strobel SA: Structural Basis for Ligand Binding to the Guanidine-I Riboswitch. Structure. 2017 Jan 3; 2016 Dec 22. PMID: 28017522 Nguyen HC, Wang W, Xiong Y: Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction. Subcell Biochem. 2017. PMID: 28271482 Chen X, Yang K, Wu C, Chen C, Hu C, Buzovetsky O, Wang Z, Ji X, Xiong Y, Yang H: Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease. Cell Res. 2016 Nov; 2016 Oct 18. PMID: 27752039 Antonucci JM, St Gelais C, de Silva S, Yount JS, Tang C, Ji X, Shepard C, Xiong Y, Kim B, Wu L: SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity. Nat Med. 2016 Oct 6. PMID: 27711056 Liang F, Longerich S, Miller AS, Tang C, Buzovetsky O, Xiong Y, Maranon DG, Wiese C, Kupfer GM, Sung P: Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex. Cell Rep. 2016 Jun 7; 2016 May 26. PMID: 27239033 Patel N, Aldahmesh MA, Alkuraya H, Anazi S, Alsharif H, Khan AO, Sunker A, Al-Mohsen S, Abboud EB, Nowilaty SR, Alowain M, Al-Zaidan H, Al-Saud B, Alasmari A, Abdel-Salam GM, Abouelhoda M, Abdulwahab FM, Ibrahim N, Naim E, Al-Younes B, E AlMostafa A, AlIssa A, Hashem M, Buzovetsky O, Xiong Y, Monies D, Altassan N, Shaheen R, Al-Hazzaa SA, Alkuraya FS: Expanding the clinical, allelic, and locus heterogeneity of retinal dystrophies. Genet Med. 2016 Jun; 2015 Sep 10. PMID: 26355662 Mahiti M, Toyoda M, Jia X, Kuang XT, Mwimanzi F, Mwimanzi P, Walker BD, Xiong Y, Brumme ZL, Brockman MA, Ueno T: Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences. MBio. 2016 Jan 19; 2016 Jan 19. PMID: 26787826 Al-Yacoub N, Shaheen R, Awad SM, Kunhi M, Dzimiri N, Nguyen HC, Xiong Y, Al-Buraiki J, Al-Habeeb W, Alkuraya FS, Poizat C: FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy. Genome Biol. 2016 Jan 11; 2016 Jan 11. PMID: 26753747 Shamseldin HE, Smith LL, Kentab A, Alkhalidi H, Summers B, Alsedairy H, Xiong Y, Gupta VA, Alkuraya FS: Mutation of the mitochondrial carrier SLC25A42 causes a novel form of mitochondrial myopathy in humans. Hum Genet. 2016 Jan; 2015 Nov 5. PMID: 26541337 Shan H, Wang Z, Zhang F, Xiong Y, Yin CC, Sun F: A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules. Protein Cell. 2016 Jan; 2015 Dec 17. PMID: 26678751 Tang C, Ji X, Wu L, Xiong Y: Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592. J Biol Chem. 2015 Oct 30; 2015 Aug 20. PMID: 26294762 Ji X, Xiong Y: Two tales (tails) of SAMHD1 destruction by Vpx. Cell Host Microbe. 2015 Apr 8. PMID: 25856752 Jia X, Zhao Q, Xiong Y: HIV suppression by host restriction factors and viral immune evasion. Curr Opin Struct Biol. 2015 Apr; 2015 May 16. PMID: 25939065 Nguyen HC, Yang H, Fribourgh JL, Wolfe LS, Xiong Y: Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex. Structure. 2015 Mar 3; 2015 Feb 5. PMID: 25661653