Xiao, Andrew - Yale University - Biological & Biomedical Sciences

个人简介

PhD University of North Carolina at Chapel Hill (2003) Postdoctoral Fellow The Rockefeller University Dr. Andrew Xiao is an assistant professor in the Department of Genetics at the Yale University School of Medicine. He is a member of the Yale Stem Cell Center. Dr. Xiao’s laboratory focuses on epigenetic regulation in pluripotent stem cells, including embryonic stem cells and induced pluripotenct stem cells (iPSC). His laboratory has made significant contributions to the understanding of the maintenance of pluripotency, as well as the recent discovery of novel epigenetic mechanisms, i.e., N6-methyl-adenine, in mammalian genomes. Dr. Xiao received his Ph.D degree from Terry Van Dyke’s lab at UNC-Chapel Hill and postdoctoral training from David Allis’ lab at Rockefeller University. Since 2009, Andrew Xiao is a recipient of the NCI Howard Temin Award in Cancer Research (K99/R00) and in 2012, he received the New Scholar Award from the Ellison Medical Foundation.

研究领域

Chromatin; DNA Damage; Genetics; Histones; Neural Crest; Stem Cells; Cellular Reprogramming

近期论文

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DNA Methylation on N6-adenine in mammalian embryonic stem cells. Wu T, Wang T, Seetin MG, Lai Y, Lin K, Zhu, S, Liu Y, Byrum SD, Mackintosh SG, Tackette A, Wang G, Hon LS, Fang G , Swenberg JA and Xiao A * DNA Methylation on N6-adenine in mammalian embryonic stem cells. (2016) Nature in press doi:10.1038/nature17640 online: march 30, 2016 Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells. Benchetrit, H, Herman, S, van Wietmarschen, N, Wu, T, Makedonski, K, Maoz, N, Yom Tov, N, Stave, D, Lasry, R, Zayat, V, Xiao, A, Lansdorp, PM, Sebban, S, Buganim, Y*. Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells. Cell Stem Cell. doi:10.1016/j.stem.2015.08.006 Histone Variant Histone Variant H2A.X-Mediated Epigenetic Mechanisms are Critical for Maintaining Genome Stability and Pluripotency in ES and iPS Cells. Wu T, Stadtfeld M, Tseng Z, Liu Y, Tahmasian M, Hochedlinger K & Xiao A*. Histone Variant Histone Variant H2A.X-Mediated Epigenetic Mechanisms are Critical for Maintaining Genome Stability and Pluripotency in ES and iPS Cells. (2014) Cell stem cell 15 (3) 281-294 PMID: 25192463 Previewed by Cells stem cell, Quality control: H2A.X links to better iPSCs. (2014) Cell stem cell 15 (3) 259-260 Previewed by Cells stem cell, Quality control: H2A.X links to better iPSCs. Buganim Y., Markoulaki S, Wietmarschen N., Hoke H., Wu T., Ganz K., Akhtar-Zaidi B., He Y., Abraha B., Porubsky D., Kulenkampff E., Faddah D., Shi L., Gao Q., Sarkar Q., Cohen M., Goldman J., Nery J., Schultz M.,. Ecker J., Xiao A., Young R., Lansdorp P. and Jaenisch R*. The developmental potential of iPSCs is greatly influenced by the selection of the reprogramming factors. (2014) Cell Stem Cell 15(3) 295-309 PMID: 25192464 Previewed by Cells stem cell, Quality control: H2A.X links to better iPSCs. (2014) Cell stem cell 15 (3) 259-2603. Maintains Telomere Length Homeostasis of Embryonic Stem Cells by Mediating Subtelomeric Heterochromatin Silencing. Dai J., Liu Y., Na L., Chiourea M., Okuka M., Wu T, Chunlin M., Wang L, Wang L, Yin Y., Yuan J., Zuo B., Wang F., Ye X., Li Z, Pan X., Yin Z., Chen L., Keefe D.J., Gagos S., Xiao A.* and Liu L* Rif1 Maintains Telomere Length Homeostasis of Embryonic Stem Cells by Mediating Subtelomeric Heterochromatin Silencing. (2014) Developmental Cell 29(1) 7-19 PMID: 24735877 WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Xiao A., Li H., Shechter D., Ahn S.H.,. Fabrizio L.A., Erdjument-Bromage H., Ishibe-Murakami S., Wang B., Tempst P., Hoffman K., Patel D.J., Elledge, S.J., and Allis C.D. (2009) WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (research article) 457, 57-62 See news and view, Nature V458, 581 Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Zhao X, Jankovic V, Gural A, Huang G, Pardanani A, Menendez S, Zhang J, Dunne R, Xiao A, Erdjument-Bromage H, Allis CD, Tempst P, Nimer SD. Genes Dev. 2008 Mar 1;22(5):640-53. doi: 10.1101/gad.1632608. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Xiao A., Wu H., Louis D.N., Pandolfi P.P., and Van Dyke T.A. (2002) Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN Mutation. Cancer Cell 1: 157-66. Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg JA, Xiao AZ: DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature. 2016 Apr 21; 2016 Mar 30. PMID: 27027282 Benchetrit H, Herman S, van Wietmarschen N, Wu T, Makedonski K, Maoz N, Yom Tov N, Stave D, Lasry R, Zayat V, Xiao A, Lansdorp PM, Sebban S, Buganim Y: Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells. Cell Stem Cell. 2015 Nov 5; 2015 Sep 24. PMID: 26412562 Dan J, Yang J, Liu Y, Xiao A, Liu L: Roles for Histone Acetylation in Regulation of Telomere Elongation and Two-cell State in Mouse ES Cells. J Cell Physiol. 2015 Oct. PMID: 25752831 Liu Y, Xiao A: Adaption by Rewiring Epigenetic Landscapes. Cell Stem Cell. 2015 Sep 3. PMID: 26340521 Buganim Y, Markoulaki S, van Wietmarschen N, Hoke H, Wu T, Ganz K, Akhtar-Zaidi B, He Y, Abraham BJ, Porubsky D, Kulenkampff E, Faddah DA, Shi L, Gao Q, Sarkar S, Cohen M, Goldmann J, Nery JR, Schultz MD, Ecker JR, Xiao A, Young RA, Lansdorp PM, Jaenisch R: The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. Cell Stem Cell. 2014 Sep 4. PMID: 25192464 Wu T, Liu Y, Wen D, Tseng Z, Tahmasian M, Zhong M, Rafii S, Stadtfeld M, Hochedlinger K, Xiao A: Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs. Cell Stem Cell. 2014 Sep 4. PMID: 25192463 Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A, Liu L: Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014 Apr 14. PMID: 24735877 Tseng Z, Wu T, Liu Y, Zhong M, Xiao A: Using native chromatin immunoprecipitation to interrogate histone variant protein deposition in embryonic stem cells. Methods Mol Biol. 2014. PMID: 25030915 Liu Y, Xiao A: Epigenetic regulation in neural crest development. Birth Defects Res A Clin Mol Teratol. 2011 Aug; 2011 May 25. PMID: 21618405