Wu, Dianqing - Yale University - Biological & Biomedical Sciences

个人简介

PhD Clarkson University (1991) BS Nanjing University (1985) Postdoc California Institute of Technology

研究领域

Chemotaxis; Inflammation; Pharmacology; Stem Cells; Signal Transduction; GTP-Binding Proteins; Chemicals and Drugs

近期论文

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A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils. Zhang, Y., Tang, W., Zhang H., Niu, X., X, Y., Zhang, J., Gao, K., Pan, W., Boggon, T.J., Toomre, D., Min, W., Wu, D. (2013) A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils. Developmental Cell, 2013. 27: 215-26. Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes. Kim, I., Pan, W., Jones, S.A., Zhang, Y., Zhuang, X., and Wu, D. (2013). Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes. J Cell Biol 200, 419-428 PRR5L degradation promotes mTORC2-mediated PKC-d phosphorylation and cell migration downstream of Ga12. Gan, X., Wang, J., Wang, C., Sommer, E., Kozasa, T., Srinivasula, S., Alessi, D., Offermanns, S., Simon, M.I., and Wu, D. (2012). PRR5L degradation promotes mTORC2-mediated PKC-d phosphorylation and cell migration downstream of Ga12. Nat Cell Biol. 10.1038/ncb2507 A PLCb/PI3Kg-GSK3 Signaling Pathway Regulates Cofilin Phosphatase Slingshot2 and Neutrophil Polarization and Chemotaxis Tang, W., Zhang, Y., Xu, W., Harden, T.K., Sondek, J., Sun, L., Li, L., and Wu, D. (2011). A PLCb/PI3Kg-GSK3 Signaling Pathway Regulates Cofilin Phosphatase Slingshot2 and Neutrophil Polarization and Chemotaxis. Developmental Cell 21, 1038-1050. Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Xu, W., Wang, P., Petri, B., Zhang, Y., Tang, W., Sun, L., Kress, H., Mann, T., Shi, Y., Kubes, P., and Wu, D. (2010). Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity 33, 340-350. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation Pan, W., Choi, S.C., Wang, H., Qin, Y., Volpicelli-Daley, L., Swan, L., Lucast, L., Khoo, C., Zhang, X., Li, L., et al. (2008). Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science 321, 1350-1353. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. Wang, Z., Liu, B., Wang, P., Dong, X., Fernandez-Hernando, C., Li, Z., Hla, T., Claffey, K., Smith, J.D., and Wu, D. (2007). Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest 118, 195-204 Regulation of PTEN by small GTPases. Li, Z., X. Dong, Z. Wang, W. Liu, N. Deng, Y. Ding, L. Tang, T. Hla, R. Zeng, L. Li and D. Wu., (2005) Regulation of PTEN by small GTPases. Nat. Cell Biol., 7399-404. (News & Views, Nat Cell Biol 7334 Editors’ Choice, Science 308327) Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Li, X., Liu, P., Liu, W., Zhang, J., Boskey, A., Harris, E. S., Rowe, D., Ke, HuaZhu, and Wu, D. (2005). Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet, 37, 945-952 Directional Sensing Requires G??-Mediated PAK1 and PIX?-Dependent Activation of Cdc42 Li, Z., Hannigan, H, Mo, Z., Liu. B, Lu, W., Wu, Y., Smrcka, A.V., Wu, G., Liu, M., Huang, C-H., and Wu, D. (2003) Directional Sensing Requires G??-Mediated PAK1 and PIX?-Dependent Activation of Cdc42. Cell 114,215-227. [Mini-review, Cell 114 153-156] Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A.V., and Wu, D. (2000). Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287, 1046-1049.